Published
in "Chromatography Techniques", December 2011, and authored by experts
from Bruker's Chemical and Applied Markets division (Fremont,
California) a new article examines how Gas
Chromatography (GC), coupled to a triple quadrupole Mass Spectrometer
(GC-MS/MS-QqQ) operated in MRM mode, is rapidly becoming the preferred
technique for multi-residue analysis in complex matrix samples by
analytical laboratories.
Transferring
from the single quadrupole to a triple quad can present potential
difficulties for the chromatographer who may not necessarily be an
expert in mass spectrometry. Bruker has introduced an innovative
user-friendly solution to this transfer with its proprietary Compound
Based Scanning (CBS) software in the company's new SCION
TM TQ system.
Major
advantages of CBS is that the new work flow focuses on compounds and
not each MRM. The MRM transition of an analyte does not need to be known
by the user. Software auto-fills information from a factory installed
read-only compound library that contains over 2,500 MRM transitions for
more than 900 common contaminants. CBS then sets up the method and
manages the TQ duty cycle during analysis and data acquisition.
Compounds in the library are linked to retention time, primary and
secondary MRM transitions, and collision energy. Using CBS dramatically
reduces the time taken to set the initial MRM methods, improving
workflow and productivity.
Analysis
of pesticides in vegetable matrix using Bruker's SCION TQ GC-MS/MS
illustrates the use of CBS for developing an MRM based method to analyze
258 pesticides (516 MRMs) dramatically reducing the time taken to set
the initial MRM methods for accurate data.
To view the publication
click here For more information about Bruker Corporation's SCION systems for GC-MS instrumentation, please visit
www.scionhasarrived.comBruker, Bruker Chemical Analysis and SCION are registered trademarks of Bruker Corporation.
