Thermo Fisher Scientific is proud to announce an
effective new method for the determination of succinic, glutaric, and adipic
acids in solutions of mixed dibasic acids generated during cyclohexane
oxidation.
Application Note 285:
Determination
of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone
Production demonstrates use of our
liquid
chromatography system (Thermo Scientific Dionex UltiMate
TM 3000 RSLC system)
with
organic
acid analytical column (Thermo Scientific Acclaim
TM OA column) and
mass
spectrometry (MS) detection to achieve a fast baseline separation of these
three dibasic acids with good resolution values (Rs ≥ 2.6), good method
reproducibility, excellent linearity within 0.1 to 5 mg/L, and accurate results
for industrial samples.
Cyclohexone is the key intermediate for the
production of adipic acid, an important compound for the synthesis of nylon 66.
Cyclohexane oxidation is the normal method for the production of cyclohexone;
and succinic, glutaric, and adipic acids, as well as their dehydration products,
are the main by-products. The three aliphatic dicarboxylic acids are also
important chemical raw materials, and their determination is important for the
quality control of cyclohexone production and recycling of the by-products.
This application note and many others can be
found at
www.thermoscientific.com/dionex
under the
Documents
tab.
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