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Malvern’s new SEC-LS dual integrated detector is dedicated to proteins
publication date: Feb 14, 2011
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author/source: Malvern Instruments Ltd
The proven Zetasizer µV offers dual DLS (dynamic light scattering) and SLS (static light scattering) capabilities. It can be used as a stand-alone detector, analyzing samples in a cuvette, and now as a fully-featured modular chromatography detector. For protein applications, this makes the Zetasizer µV an ideal tool. Applications in stand-alone batch mode include the study of molecular size and formulation stability, and in SEC detector mode the measurement of molecular weight, determination of oligomeric state and detection and quantification of oligomers and aggregates. The absolute nature of the measurement means that no column calibration is required. The Zetasizer µV is available as a complete chromatography system or can be added to existing SEC modules. Malvern's OmniFACE provides the necessary connection that enables the Zetasizer µV to be linked into any third party SEC system and detectors, so that output signals can be used by the OmniSEC software for results calculation. Connecting the Zetasizer µV is simplicity itself. Using standard chromatography tubing it can be added in series with other detectors such as UV and RI. The laser stability and optical setup of the Zetasizer µV ensure excellent baseline stability and signal-to-noise for maximum sensitivity, while the 8 μL flow cell minimizes band broadening. Visit www.malvern.com/Zetasizeruv for full details. Malvern offers a range of solutions for characterizing natural and synthetic macromolecules. These include the Zetasizer family, employing dynamic and static light scattering to measure size and molecular weight; Viscotek advanced gel permeation chromatography/size exclusion chromatography (GPC/SEC) systems and detectors for rapid, reliable characterization of molecular weight and molecular structure; and the Sysmex FPIA-3000 for dynamic imaging including applications for characterizing sub-visible/visible particles and the size and shape of protein aggregates. www.malvern.com/Zetasizeruv |
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Malvern Instruments has launched the Zetasizer µV with OmniFACE and OmniSEC, a new SEC-LS (size exclusion chromatography - light scattering) detector package dedicated to protein analysis.