From headquarters located in Kyoto, Japan, YMC has gradually and consistently matured to a level of international recognition, specifically within the pharmaceutical and biotech world, as one of the leading suppliers of analytical and process-scale silica-based stationary phases for High Performance Liquid Chromatography, preparative equipment, custom purification and method development.
New: Micro Reactor / Flow Chemistry scalable to production scale!
Qualified technical support and backup is available through operations in Japan, the United States (for the "Americas"), India, China and Germany (for Europe, Africa and the Middle East).
With YMC-TriArt challenging pH-stability and high temperatures are no longer a limitation to your work. Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-TriArt a “First Choice” column in method development...
This collection encompasses the full spectrum of YMC HPLC applications into a single volume covering all RP, IEX, SEC, HILIC and NP separation mechanisms...
Until now the extremely efficient YMC-BioPro IEX phases have only been available as bulk media. Still it was introduced into many screening procedures in industry, because of its high quality. Now it is even easier to evaluate its extremely good cost-efficiency ratio: YMC announces the introduction of pre-packed IEX columns...
Is it possible to get the best of both worlds? Better quality at better price? It is possible with the new YMC HG-grade series of silica based materials! These new phases combine the trusted selectivity of the YMC*gel materials with a new high performance silica base. The most obvious advantage of the new silica base is its extended mechanical stability which is due to an improved production process for the base silica...
As a long-time specialist in the field of glass Pilot columns for lab and production separations, Kronlab specialists are continuously in close dialogue with chromatography end-users from Pharma/Biotech as well as research and education fields. This leads to numerous technical and practical modifications which make your every-day work a lot easier.
Chirality has become vitally important in the production of pharmaceuticals, agrochemicals and related products, due to the dramatically different pharmacology the various optical isomers can present, ranging from no activity through undesirable effects to having potentially catastrophic and sometimes life threatening adverse effects. This has led to the development of highly efficient chiral stationary phases (CSP) for analytical and preparative scale separations
Reversed phase chromatography is undoubtedly the most powerful method for peptide purification. In order to improve the cost effectiveness of industrial scale peptide purifications, YMC has developed a new hybrid silica base and a novel bonding technology to improve process efficiencies and inrease column life time.
The new HPLC brochure “YMC Phases for Biochromatography” is available now! It contains current applications for biomolecules using various separation mechanisms including IEX, SEC, RP and HILIC.
A further milestone for YMC-BioPro IEX materials has been reached. The Regulatory Support File (RSF) for these high performance IEX resins has been finalized and is now available.
YMC is a specialist in difficult, multistep syntheses in the micro-reactor. Higher yields, substances that are available more quickly and with extensive downstream processing guarantee substances up to the highest purity.
Every two years the leaders in preparative chromatography meet for the Symposium on Preparative and Industrial Chromatography and Allied Techniques (SPICA). As a supplier strongly rooted in preparative chromatography, YMC will participate in two ways:
Sometimes one does not see the woods from the trees – or in other words: for some people it is evident, but not so for the others. With regards to Kronlab glass columns there are two questions still frequently asked..
In the laboratory glass columns are favoured by many chromatographers because of their inertness towards proteins. Also the possibility to clean the packed columns with highly alkaline caustic soda solutions, a widely-used purification step, is a good argument for glass columns.
Often client specific requirements for multipurpose equipment can not be solved with “off the shelf“ solutions. In this specific case, the Kronlab custom build approach proved very useful: every component has been specifically approved for the application at hand and following a specified procedure it is integrated into an LC system. The result is a made-to-measure system.
Microreactor technology, is currently one of the most innovative techniques in the field of chemical synthesis and similar fields. Now specific microreactors are coming to laboratories. Scientific advances throughout the world have demonstrated the many advantages which can be achieved through the use of microreactors for chemical reactions and processes.
Customised requirements for GMP-conforming extraction of substances are often not satisfied by “off-the-shelf” solutions. Every component in the well-established modular systems from Kronlab meets the requirements which will be demanded by the customers’ needs for an established procedure. The result: A made-to-measure system
Run at our laboratory facilities in Dinslaken, Germany, this hands-on course is designed to introduce both theory and practical concepts of preparative liquid chromatography.
A released gas in mobile phases during analysis causes noisy baselines and pressure fluctuations which affect sensitivity and reproducibility. It also severely compromises the use of fluorescence-, refractive-index- or UV-detectors (particularly at wavelengths below 210 nm). As a consequence effective mobile phase degassing must be employed for many analyses.
Simply high dynamic binding capacities (DBC’s) are no longer sufficient. High DBC, at high flow rates with close to 100% recovery, across a wide range of molecular weights, this is what chromatographers look for in modern ion exchange resins. “BioPro” YMC’s hugely successful ion exchange material offers exactly this. The growing user base confirms very good separation, high dynamic binding capacities and excellent recoveries for the anion as well as the cation exchanger material.
With YMC-Triart challenging pH-Stability and high temperatures are no longer a limitation to your work. Above all due to its unique particle composition a balanced hydrophibicty and silanol activity are achieved which makes YMC-Triart a “First Choice” column in method development!
YMC-BioPro Q30 and S30 are high performance ion exchange resins designed for the purification of proteins, peptides, antibodies and oligonucleotides in laboratory and industrial scale.
Controlling the temperature of a column is a prerequisite for reproducible results in HPLC. Column ovens are part of most HPLC systems and many of them offer space even for semi preparative columns. But with increasing inner diameter the heat transfer from the air surrounding the column to the whole cross section of the column (filled with the cold mobile phase) becomes more and more difficult. This may result in bad peak shapes, as the radial temperature gradientcauses different separation conditions for every part of the sample depending on its distance to the outer diameter.
As chromatographers, we all know the problems during method development - “Which phase is suitable and allows a simple and robust separation?” In the field of biochromatography, phase selection is a key to success!
Kronlab ECO glass columns meet highest quality demands. They are best suited for various chromatographic techniques like ion exchange, affinity and size exclusion chromatography.
YMC-Actus is available in a range of C18phases including ODS-AQ with its hydrophilic endcapping, as well as a C8 phase to allow use of the full spectrum of RP-HPLC methods.
In order to succeed in developing protein-based drugs, a fast and easy detection of alteration within the protein structure is necessary. In many cases, peptide mapping is the method of choice, where proteins are analysed after digestion.
The new YMC-UltraHT brochure from YMC includes information on how to transfer methods form existing, conventional methods to ultra fast LC, without generating excessive backpressure and without the need of specialised ultra high pressure chromatography equipment.
The method transfer from a conventional column to an ultra fast analysis for alkaloids has shown that the use of YMC-UltraHT 2 µm column and adjustment of flow parameters for the smaller column dimensions can reduce the analyses time by about 85% accompany with significant solvent savings and significant solvent savings whilst increasing the sample throughput in the laboratory.
For several reasons the storage of 100% pure solvents in the reservoir bottles of an HPLC system can be a problem. Pure acetonitrile, in particular, affects the system by adsorption of polymers from transmission lines resulting in sticky surfaces that inhibit the opening and closing of the valves
With the constantly rising population and frequent uncertain weather, the need for high yielding agriculture is paramount. This means that use of plant protection agents, such as herbicides and insecticides is necessary, in order to secure harvests.
Normal phase chromatography is not very popular with most analytical HPLC users. Poor reproducebility of the results is often cited as an argument against normal phase chromatography.
The Ion Exchange capture material is based on the same hydrophilic polymer matrix already used for the successful analytical phase. Analytical BioPro columns (particle size: 5 μm, pore size 100 nm) have proven to show low non specific binding and high dynamic binding capacity.
With continuously increasing volumetric productivity in fermentation processes, new stationary phases can help to overcome shortcomings in downstream processing. In order to address this YMC has developed a new Ion Exchange resin with high dynamic binding capacity and low nonspecific interaction. This helps to reduce “cost of goods” in the production process.
The plant pigment curcumin, found in the popular Indian curry spice turmeric, is well known as an antioxidant for foods. However, researches have paid attention to another characteristic. Curcumin is highly active against the growth of certain cancers.
YMC is pleased to introduce Exphere, a new family of bulk packing materials, specifically designed for preparative liquid chromatography. Exphere combines YMC's novel high strength silica with a special polymeric surface modification technique.
Melamine (sometimes confused with the plant and animal compound, melanine or another compound, melanin) is an industrial chemical used in the manufacture of plastic products. Despite that, tests showed that a number of milk companies have used it in processing milk to artificially increase the apparent protein content by addition of non-protein nitrogen and so allowing illegal dilution of the product with water with a corresponding increase in sales value.
This collection encompasses the full spectrum of YMC HPLC applications into a single volume covering all RP, IEX, SEC, HILIC and NP separation mechanisms...
Until now the extremely efficient YMC-BioPro IEX phases have only been available as bulk media. Still it was introduced into many screening procedures in industry, because of its high quality. Now it is even easier to evaluate its extremely good cost-efficiency ratio: YMC announces the introduction of pre-packed IEX columns...
Is it possible to get the best of both worlds? Better quality at better price? It is possible with the new YMC HG-grade series of silica based materials! These new phases combine the trusted selectivity of the YMC*gel materials with a new high performance silica base. The most obvious advantage of the new silica base is its extended mechanical stability which is due to an improved production process for the base silica...
As a long-time specialist in the field of glass Pilot columns for lab and production separations, Kronlab specialists are continuously in close dialogue with chromatography end-users from Pharma/Biotech as well as research and education fields. This leads to numerous technical and practical modifications which make your every-day work a lot easier.
Chirality has become vitally important in the production of pharmaceuticals, agrochemicals and related products, due to the dramatically different pharmacology the various optical isomers can present, ranging from no activity through undesirable effects to having potentially catastrophic and sometimes life threatening adverse effects. This has led to the development of highly efficient chiral stationary phases (CSP) for analytical and preparative scale separations
The new HPLC brochure “YMC Phases for Biochromatography” is available now! It contains current applications for biomolecules using various separation mechanisms including IEX, SEC, RP and HILIC.