Thermo Fisher Scientific has developed a simple,
fast, sensitive, and robust capillary
ion chromatography (IC) analytical method to simultaneously quantify three bisphosphonate
pharmaceuticals (etidronate, clodronate and tiludronate) and three commonly
used excipients (benzoate, hydroxybenzoate and citrate). Application Note 1001:
Quantitative
Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary
IC-MS uses a Thermo Scientific Dionex IonPac AS18-Fast
capillary
anion-exchange column to achieve chromatographic retention and resolution
for target analytes. The elimination of derivatization steps simplifies the
workflow and improves method throughput. Detection by
suppressed
conductivity provides sufficient sensitivity for quality control (QC)
analysis and mass spectrometry (MS) offers additional selectivity and
sensitivity for bisphosphonates in complex matrices, such as biological fluids.
Bisphosphonates are a group of compounds that
are used as active pharmaceutical ingredients (APIs) to treat bone disorders
and related conditions, including osteoporosis, Paget's disease, and
hypercalcemia.
This application note and many others can be
found at
www.thermoscientific.com/dionex
under the
Documents
tab.
About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science. Our
mission is to enable our customers to make the world healthier, cleaner and
safer. With revenues of $12 billion, we have approximately 39,000 employees and
serve customers within pharmaceutical and biotech companies, hospitals and
clinical diagnostic labs, universities, research institutions and government
agencies, as well as in environmental and process control industries. We create
value for our key stakeholders through three premier brands, Thermo Scientific,
Fisher Scientific and Unity
TM Lab Services, which offer a unique combination of
innovative technologies, convenient purchasing options and a single solution
for laboratory operations management. Our products and services help our
customers solve complex analytical challenges, improve patient diagnostics and
increase laboratory productivity.
All trademarks are the property
of Thermo Fisher Scientific Inc. and its subsidiaries.
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