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Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, is pleased to announce the launch of ISOLUTE® FILTER+ high performance filtration plates, for the processing of samples prior to UPLC-MS/MS, alongside a diverse range of other filtration applications.

ISOLUTE® FILTER+ plates offer high performance filtration of diverse biological samples, ideal for use with urine prepared by ‘dilute and shoot’, prior to UPLC-MS/MS analysis. Each plate contains a 0.2 µm membrane filter for particulate removal, topped by a depth filter to prevent blocking of the membrane. ISOLUTE® FILTER+ plates offer improved workflow compared to filtration vials or syringe type filters, and allow high throughput filtration for UPLC analysis.

The new plates are designed to prevent sample particulates from reaching the UPLC column, protecting the analytical system from particulate build up over time.  Increased back pressures due to particulate accumulation necessitate frequent downtime for replacement or regeneration of the expensive columns. The filtration membrane is wettable, eliminating the need for pre-wetting, and narrow plate outlets direct sample flow into the collection plate without sputtering, eliminating cross talk between samples.

ISOLUTE® FILTER+ plates can be processed using 96-well compatible positive pressure manifolds, (e.g. Biotage® Pressure+ 96) vacuum manifolds, (e.g. Biotage® VacMaster™ 96) and automated liquid handling systems (e.g. Biotage® Extrahera™). Typically, sample volumes of up to 1,500 µL (total volume) can be processed using this product.

“Requiring no method development, ISOLUTE® FILTER+ can be integrated quickly and easily into routine workflow, reducing sample transfer steps and increasing productivity.” said Dr. Claire Desbrow, Global Product Manager, Analytical Chemistry, Biotage.

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