TAP Biosystems, a
leading supplier of innovative cell culture systems and consumables for life
science applications is delighted to announce I-Stem, a major French stem cell
research institute, is using a CompacT SC automated cell culture system and Fill-It
automated cryovial filing and capping system to reproducibly generate and
rapidly bank a range of pluripotent stem cells.
Scientists
at I-Stem are currently using the CompacT SC to automate differentiation and
expansion of stem cells, allowing the generation of human pluripotent cell
lines of consistent high quality. They are then using the Fill-It system to
prepare these cell lines for storage in the I-Stem biobank, which is France's
largest human embryonic stem cell bank. The cells produced are either stem
cells containing specific disease mutations or stem cells for use in clinical
trials as cellular therapies. Both of these approaches will enable advances in
the treatment of many debilitating human diseases.
Dr
Yacine Laabi, Senior Group Leader of Stem Cell Biotechnologies at I-Stem said:
"My group is working with human pluripotent induced progenitor cells for skin,
muscle, neurons and retina. We decided two years ago that automation was
essential because it would offer us greater reproducibility in both process and
cell quality. We reviewed systems from several companies but chose CompacT SC
as the published literature shows the system works well with mesenchymal and
neuronal stem cells and we believed it would be most suited to our research."
Dr
Laabi continued: "We use the CompacT SC to differentiate cells into specific
lineages and it is ideal for this because the system has chilled storage for
expensive cytokines, which allows us to add these at the correct time to
maintain our cell lines in specific states. By using a newly developed flask
adaptor, we can also process T75 flasks, so we can work with smaller scale
cultures using less of the costly media and growth factors. We then use Fill-It
to dispense our final stem cells harvests into cryovials for storage. This
integrated workflow improves our process standardisation and reduces the chance
of contamination because human contact with each cell line is kept to a
minimum."
Dave Thomas, Product Manager at TAP Biosystems concluded: “We are delighted our CompacT SC and Fill-It systems have passed the rigorous acceptance testing at I-Stem. I-Stem’s adoption of our technology is an excellent demonstration of how this automated workflow can be implemented for culturing and processing consistent high quality stem cells for use in many critical research and clinical programmes.”
For further information visit
www.tapbiosystems.com
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