Integrated DNA Technologies (IDT), the
world leader in oligonucleotide synthesis, offers a comprehensive range of
customizable products for RNA interference (RNAi) applications. The Screening
Dicer-substrate siRNA (DsiRNA) provides researchers with a cost-effective and
quick solution for their RNAi requirements. IDT's DsiRNAs are chemically synthesised
27-mer RNA duplexes optimised for Dicer processing and incorporation into the
RISC complex, resulting in an increase in potency. IDT's Pre-designed library
includes over 3,000,000 DsiRNAs designed against human, mouse, rat, cow, dog,
chicken and chimp transcriptomes within RefSeq, enabling the production of
DsiRNAs to meet the majority of user requirements.
When developing pre-designed DsiRNA duplexes, site selection is
first performed using a proprietary algorithm with novel design rules. The
sequences are subsequently screened to minimize the potential for
cross-hybridisation and off-target effects, while sequences containing any
known small nucleotide polymorphisms (SNPs) or alternatively spliced exons are
eliminated. IDT therefore offers two variants of predesigned DsiRNA duplexes:
splice common and splice specific. Splice common duplexes target all known
variants of a gene in RefSeq and 8 - 10 duplexes are available for each target
gene. Splice specific duplexes target exons present in particular splice
variants, making them ideal for researchers targeting specific isoforms.
Further to the range of pre-designed products, IDT offers
researchers custom DsiRNA, RNAi duplex oligos, custom RNAi design as well as
antisense oligos. Produced on IDT's proprietary high-throughput synthesis
platform, the process has been designed to assure a high quality product at a
low cost. Facilitating ease of use, custom orders can be placed via the
user-friendly SciTools interface.
For more information on the complete range
of IDT's products please visit
www.idtdna.com.
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