At the Seventh
annual PEGS conference held in Boston, MA, TTP LabTech released data
demonstrating the use of their novel acoustic biosensor, LIBRA
2, for
the study of glycosylation patterns on cell membranes. TTP LabTech invited scientists to Booth 304 to view the data and discuss future
developments and applications of the LIBRA
2 technology.
Changes in
glycan structures are becoming increasingly recognized as one of the most
prominent biochemical alterations associated with malignant transformation and
tumourogenesis. Exploiting Resonant Acoustic Profiling (RAP), LIBRA
2
has been used to characterise the binding of label-free lectin onto immobilised
mammalian cells creating a profile of glycolipoprotein and glycolipid
expression. Such studies are often found to be challenging by traditional
analytical techniques.
Biosensor
Product Manager, Dr Helge Schnerr is excited about the potential of LIBRA
2
to profile the glycosylation patterns of cancer cells and commented that "the
ability to define both the nature of such glycans, using lectins or monoclonal
antibodies with this novel cell-based acoustic biosensor, may provide useful
diagnostic or prognostic information in oncology research and therapy".
Mirrorball
®, the high sensitivity laser scanning
microplate cytometer for antibody discovery, was also be available for
demonstration with TTP LabTech at Booth 304. For more information on the
applications and capability of the LIBRA
2® or Mirrorball
® systems,
please visit
www.ttplabtech.com/products/libra2/index.html
or
www.ttplabtech.com/mirrorball.
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