Researchers at the RCPE (Research
Center Pharmaceutical Engineering) in Graz, Austria, are finding the
reproducibility of the FT4 Powder Rheometer from Freeman Technology
crucial to the success of their work on modelling powder behaviours. The RCPE
is a unique internationally operating European research institute in the area
of pharmaceutical process and product development, and a focal point for
rational and science-based development of novel pharmaceutical drug products,
as well as their manufacturing processes.
The FT4 is being used in a number of
areas, one of which is the development of models that support the optimisation
of powder blending, a critically important industrial operation. A
notable success has been achieved with models that allow the successful
correlation of powder blend characteristics with the properties of the
constituents.
Commenting on his group's use of the
FT4, Deputy Director of the RCPE Dr Simon Fraser said, "Reproducibility was a
major factor in our choice of powder testing instrument for this work. The FT4
delivers extremely high reproducibility, greater than that achievable with
alternative techniques and instruments, giving us the cleanest possible data
sets for modelling. Added to that we have enjoyed highly knowledgeable support
from Freeman Technology who have engaged with and encouraged this research from
the outset."
Using a Design of Experiments (DoE)
approach and multivariate data analysis (MVDA), the research team has developed
reliable models for the prediction of a number of different blend properties.
NIR spectroscopy has been used to monitor the efficiency of blending in further
trials conducted to link off-line tests on constituents and well-defined powder
blends with the actual industrial powder blending process. This work continues
with more experiments planned.
The FT4 Powder Rheometer delivers
precise and highly reproducible dynamic, shear and bulk powder
measurement. Automated well-defined measurement protocols include a
conditioning step, prior to analysis to provide the most stable of baselines
for measurement. Sensitive and flexible, the FT4 is widely used for
process-related studies across the pharmaceutical industry and other industry
sectors.
For information about RCPE Graz please
visit
http://www.rcpe.at
Details of Freeman Technology and the
FT4 at
www.freemantech.co.uk
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