Thermo Fisher Scientific Inc., the world leader in
serving science, today announced a new comprehensive method that uses triple
quadrupole GC-MS/MS to achieve lower levels of detection of volatile
nitrosamines (VNA) in tobacco. The new method allows environmental
laboratories, tobacco companies and government agencies to efficiently separate
VNAs while lowering detection limits, increasing specificity and enabling the
analysis of many other contaminants in tobacco, including pesticides. The new
method is detailed in an application note entitled "Lower Detection Limits of
Volatile Nitrosamines in Tobacco by Triple Quadrupole GC-MS/MS," available to
download at
www.thermoscientific.com/vna.
Volatile nitrosamines are a class of compounds that can
form in tobacco smoke, as well as during the curing and processing of tobacco.
These compounds have been proven to have adverse effects on human health; and
two of the VNAs found in tobacco, N-nitrosodiethylamine (NDEA) and
N-nitrosodimethylamine (NDMA), are classed as known human carcinogens by
regulatory authorities. As a result, these compounds must be thoroughly
monitored in order to safeguard human health and comply with increasingly
stringent regulations.
The new Thermo Fisher method is a powerful alternative to
other traditionally used techniques. By coupling a gas chromatograph to a
triple quadrupole mass spectrometer, the new method makes detection limits of
1ng/mL achievable, enabling users to satisfy the increasingly lower detection
limits required by governments and regulatory bodies. The method also increases
contaminant specificity within a classification and allows many other organic
contaminants and chemicals in tobacco to be analyzed simultaneously, including
pesticides.
The new method includes GC-MS/MS analysis on the Thermo
Scientific TSQ Quantum XLS triple quadrupole GC-MS/MS system using timed
selected reaction monitoring (t-SRM). This unique feature enables easy method
set-up and allows users to run samples while the instrument automatically
determines the optimal time for SRM parameters.
For more information on the new Thermo Fisher GC/MS-MS
method for the detection of VNAs in tobacco or to obtain a copy of the
application note, please call +1 866-463-6522, e-mail
analyze@thermofisher.com or visit
www.thermoscientific.com/gc.
About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world
leader in serving science. Our mission is to enable our customers to make the
world healthier, cleaner and safer. With revenues of nearly $11 billion, we
have approximately 37,000 employees and serve customers within pharmaceutical
and biotech companies, hospitals and clinical diagnostic labs, universities,
research institutions and government agencies, as well as in environmental and
process control industries. We create value for our key stakeholders through
two premier brands, Thermo Scientific and Fisher Scientific, which offer a
unique combination of continuous technology development and the most convenient
purchasing options. Our products and services help accelerate the pace of
scientific discovery, and solve analytical challenges ranging from complex
research to routine testing to field applications. Visit
www.thermofisher.com
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