The white paper “Adopting Next Generation Labeling Technology Enhances Enterprise Agility and Reduces Costs” published by NiceLabel identifies the hidden costs, inefficiencies and risks resulting from legacy labeling operations and explains why a modern label management platform is well suited to current enterprise and extended supply chain needs.
In today’s networked economy, organizations are challenged with volatile market requirements, massive connectivity driven by the "Internet of Things", and increased product, process, and supply chain complexity. Enterprises are continually looking deeper into their operations and farther across their supply chains for opportunities to become more efficient. Labeling is frequently considered a background process that does not get...
Chromatrap®, a business unit of Porvair Sciences, has published a new application note that describes how Chromatrap® ChIP-seq assays now enable unbiased, genome-wide understanding of protein-DNA regulatory networks.
Genome-wide mapping of protein-DNA interactions is essential for a complete understanding of gene regulation. A detailed map of epigenetic marks and transcription factor binding is necessary for deducing the regulatory networks that underpin gene expression in a variety of biological systems. The most widely used tool for examining these interactions is ChIP followed by massively parallel sequencing (ChIP-seq). The new application note reports on how...
Positive displacement pipettes have been used for many years for PCR applications. Gilson, experts in liquid handling have published three new papers which describe the use of positive displacement technology to help solve the issues of pipetting problem liquids.
Gilson’s MICROMAN E positive displacement pipette with its Capillary Pistons helps scientists counter common pipetting problems that may affect accuracy and precision when working with problem liquids. Leaks are known to occur when pipetting volatile solutions such as acetone, hexane and ethanol with an air-displacement pipette.
‘Extending the boundaries of QbD’, a new whitepaper from Malvern Instruments, explores the application of Quality by Design (QbD) principles to the development of analytical instrumentation and the benefits this brings for users.
Taking the example of Malvern’s development of the Mastersizer 3000 particle size analyzer, the authors illustrate how instrument companies are aligning with the QbD philosophy. This offers pharmaceutical customers the reassurance of closely similar working practices and products that meet exacting customer standards. The central idea of QbD is that quality should be built into a product from the outset. It is an approach based on...
The incredibly powerful potential of photochemistry is revealed in four application notes recently posted by Suffolk-based flow chemistry engineering firm Vapourtec.
The four application notes cover 'Synthesis of Artemisinin using E-Seriesand UV-150 reactor' (Application Note 39), 'α-Photodecarboxylation of Phthaloyl Glycine' (38), 'Photochemical Transformation of Methyl Coumalate' (37) and '[2+2] Photocycloaddtion of Maleimide and 1-Hexyne' (36) and are available to download in full from the Vapourtec website. Vapourtec MD and founder Duncan Guthrie explained: "Taken together these...
Porvair Sciences, in conjunction with researchers at Swansea University (UK) have written a new technical article entitled 'Chromatrap® 96: a new solid-state platform for high-throughput Chromatin Immunoprecipitation (ChIP)'
Epigenetics is a fast-growing research area with wide applications, including disease mechanism profiling and personalized medicine strategies. ChIP is crucial to epigenetic research. Published in the latest issue of Nature Methods (11, 2014) the article provides an introduction to Chromatrap® 96 - a high-throughput ChIP analysis platform and demonstrates how it is able to profile up to 96 transcription factors and epigenetic modifications...
Exeter Analytical has published an application note demonstrating the utility of its Model 440 CHN microanalysis system for precise determination of percentage Carbon, Hydrogen and Nitrogen content of often demanding liquid samples.
The analysis of liquid samples, including volatile liquids, can be done quite easily on the Exeter Analytical Model 440 system without sacrificing accuracy or precision and without the need for expensive liquid autosamplers. The new application note 233 describes how a special liquid sample preparation technique together with controlled introduction of the sealed capsules into the Model 440 eliminates the problems associated with...
A new white paper from Copley Scientific provides expert guidance on how to use breathing simulators effectively when testing orally inhaled products (OIPs).
Breathing simulators are machines that mimic the inhalation and/or exhalation profile of a patient and are used increasingly in OIP testing. Copley Scientific’s white paper clearly explains where breathing simulators are specified by pharmacopoeial methods and also where their optional use is beneficial. This may be in improving understanding of product performance, for example, or to support a Quality by Design (QbD) approach...
Read MoreCLSI Releases New Standard on Laboratory Internal Audit ProgramsMar 4, 2014
The Clinical and Laboratory Standards Institute (CLSI) has released a new quality management systems standard on laboratory internal audit programs.
A laboratory audit program is critical to ensuring laboratories meet applicable requirements for quality system essentials assessments. QMS15-A—Laboratory Internal Audit Program; Approved Guideline provides guidance for how a laboratory can establish an internal audit program to enhance the quality of its services through continual improvement. Whereas an audit program defines the “who,” “what,” “when,” “where,” and “how” of meeting requirements for internal auditing, the audit process describes the details of how to conduct individual laboratory internal audits...
Frederic Girard, CEO of Spinnovation Biologics, has authored a new article detailing the benefits of novel Spedia-NMR™ and NMR technology for Quality by Design (QbD) process development within biologics production.
Entitled ‘Fingerprinting Culture Media’, the article was published in January 2014’s edition of European Biopharmaceutical Review and is now available for download online. The QbD initiative is rapidly being adopted throughout the conventional and bio-pharmaceutical industry to ensure product quality and consistency within manufacture. Exploring the background of the growing QbD movement within biotechnology....
Freeman Technology, a global provider of powder testing instruments, and GEA Pharma Systems, a company that specialises in the design and development of processing solutions for the pharmaceutical industry, are collaborating to advance the application of continuous wet granulation and drying technology in the pharmaceutical industry.
The work involves Freeman Technology’s FT4 Powder Rheometer® and GEA Pharma Systems’ ConsiGma™ 1 continuous granulation unit. Data from the FT4 are being used to quantify the influence of the operating conditions of the ConsiGma1 on the bulk characteristics of the granules being manufactured. These data are then correlated to attributes of the tablets, providing the link between granule and tablet properties.....
Read MoreNew whitepaper highlights impact of NGS target enrichment assay choiceDec 17, 2013
OGT provides insight on NGS enrichment optimisation
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a free whitepaper titled ‘The importance of enrichment assay choice and optimisation for confident variant detection.’ The paper investigates the main strategies employed to optimise target enrichment for next generation sequencing (NGS) assays, assisting researchers to make informed decisions when designing studies...
A new application note from Malvern Instruments explores the role of particle size and the importance of particle size measurement in optimizing the formulation of drilling muds used in oil extraction processes.
The particle size of drilling mud components exerts a significant influence on the performance of the final drilling mud product. Rapid, reliable measurement and control of particle size is especially important when tailoring drilling mud formulations for individual geological situations and drilling operations. This new publication focuses on the use of laser diffraction particle sizing for this application, exploring the steps involved and providing examples of typical data generated.....
Read MoreProtocol for Preparing Top Quality Lyophilised SamplesDec 11, 2013
Genevac has developed a protocol using its SuperCool 75 condenser
Genevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...
The launch of Malvern Instruments’ Viscotek SEC-MALS 20 chromatography detector has triggered record downloads of one of the supporting white papers ‘Static light scattering technologies for GPC/SEC explained’, underlining the enthusiasm amongst users for straightforward information on GPC/SEC analysis.
The recent addition of Viscotek SEC-MALS 20 to Malvern’s range of detectors puts the company in the unique position of being the sole provider of every commercially available light scattering technology for GPC/SEC. Customers can therefore be assured of a truly unbiased choice of detector solutions. The popular white paper is just one of a suite of educational information and application notes provided by Malvern’s specialist team to help users select the right detector for their application...
A new article detailing a round table discussion on quality by design (QbD) authored by leading industry experts including Spinnovation Biologics CEO Frederic Girard is now available online.
Entitled ‘QbD and PAT in Upstream and Downstream Processing’, the article details the fundamental principles of QbD, how it is used to improve process control, and the impact technological advances have made on QbD biopharmaceutical upstream process optimization. Originally published in the July addition of Biopharm International the full article is now available to read...
Uniqsis has published details of a mild nitration method using its FlowSyn flow chemistry system that enables short reaction times and high conversion to be achieved whilst minimising the amount of corrosive (and potentially explosive) hot nitrating mixture present in the reactor at any one time.
Nitration is an important synthetic procedure that is often difficult to control. Under continuous flow-through conditions, however, exotherms are typically well controlled and nitration can be safely performed on a large scale. Using Uniqsis’s proprietary glass static mixer/reactor chip technology - nitration can be safely performed under accelerated conditions at elevated temperature and pressure without the associated problems typically encountered in batch reactors of controlling latency periods or controlling thermal run away...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download whitepaper titled ‘When to use targeted resequencing — Choosing the right NGS method.’ The paper aims to assist researchers when planning NGS strategies by providing a detailed review of the major resequencing methods. Comparing and contrasting method suitability, the paper also examines the significant impact of data analysis, as well as time and cost considerations...
METTLER TOLEDO is pleased to present a new white paper to help those working in the Chemical, Food, Consumer Product, and Mineral industries meet the challenge of understanding, optimizing and controlling particle and droplet systems in a variety of applications including suspensions, emulsions and crystallizations.
“Best Practice for Inline Particle Size Characterization” reviews a series of real-life examples where prominent food, chemical and consumer product companies have used inline characterization methods to measure real time particle size dynamics at full-process concentration to ensure repeatable process endpoints, improve yield, and optimize product quality. Inconsistencies in solid or liquid dispersion, agglomeration or precipitation can create variability in product stability and manufacturing throughput...
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download application note on combined array comparative genomic hybridisation (aCGH) and single nucleotide polymorphism (SNP) arrays.
The application note, titled ‘Detecting copy number variants and runs of homozygosity on a single array — challenges and applications’ aims to support researchers in navigating this combined approach for the simultaneous detection of copy number variations (CNVs) and runs of homozygosity (ROH). aCGH has established itself as the “gold-standard” platform for array-based CNV detection. Recent advances have enabled the combination of aCGH probes for CNV detection with probes able to detect SNPs...
Drawing upon many years’ experience of designing and supplying liquid flowmeters to meet stringent OEM specifications - Titan Enterprises has produced an informative white paper 'How to specify liquid flowmeters'.
Accurate, reliable, cost effective flow measurement is more important today than it has ever been. However the optimal liquid flowmeter varies considerably according to a wide range of operational parameters including pipe bore, flow path, liquid viscosity, particulate levels, measurement accuracy, measurement dynamic range, maintenance and target purchase price...
Porvair Sciences has announced an application note describing the excellent results achievable from a new 96-well format version of its ChromaTrap chromatin immunoprecipitation (ChIP) assay technology.
Developments in the field of epigenetics are rapidly expanding as researchers elucidate the principles governing gene regulation through the in vivo dynamic binding of proteins to DNA. Key to this is the need to analyse large numbers of high and low abundant regulatory mechanisms to systematically map protein-DNA interactions following pathogen/disease stimulus...