Imaging
specialist Dr Deborah Huck from Malvern Instruments will present a
poster at Drug Delivery to the Lungs 22 (7-9 Dec, Edinburgh, Scotland)
exploring how automated imaging can be used alongside cascade impaction
to support the development of inhaled drug products. Hanne Kinnunen of
the Department of Pharmacy and Pharmacology, University of Bath (UK), will also reference work with the Morphologi G3-ID in her presentation ‘Effect of lactose fines on the de-agglomeration behaviour of dry powder inhaler formulations', on Friday 9 December.
Dr
Huck's poster will report on work performed with the Morphologi G3-ID
system to examine the size and shape of the fractions delivered by
cascade impaction.
Cascade
impaction is used to measure the aerodynamic particle size distribution
of the active ingredient of orally inhaled and nasal drug products
(OINDPs). Normally material collected on each impactor stage is analyzed
by HPLC to determine the amount of active present. This gives essential
compositional data but no information about the morphology or structure
of the particles present. The poster reports on this additional step
and the extra insight the data provides.
Since
the Morphologi G3-ID combines automated imaging with Raman
spectroscopy, it offers further scope to add chemical identification to
the particle size and shape data. It is anticipated that this additional
information will in future provide new insight into the dispersion
mechanisms occurring during drug delivery and support their improvement.
For further information about the Morphologi G3-ID please go to:
http://www.malvern.com/raman or visit the Malvern stand at DDL22.
Malvern, Malvern Instruments and Morphologi are registered trademarks of Malvern Instruments Ltd
