Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

New Device for Early Diagnosis of Human Cytomegalovirus (HCMV) in Development

publication date: Nov 5, 2014
 | 
author/source: Cardiff University

Researchers from Cardiff and Swansea Universities have been awarded a grant of more than £323k to develop a new, non-invasive, low-cost, and easy to use point of care device to diagnose Human Cytomegalovirus (HCMV).

cardiff universityHCMV, a member of the herpes family of viruses, can have serious health consequences for those with weak immune systems, and a “devastating impact” on pregnant women and their babies if infected.

The grant is a prestigious Product Development Award under the National Institute for Health Research Invention for Innovation (NIHR i4i) scheme to Dr Vincent Teng of Swansea University’s College of Engineering, Dr Richard Stanton of the Institute of Infection and Immunity at Cardiff University’s School of Medicine, and the Wales Specialist Virology Centre.  It will support a three-year project which began this month (October 1, 2014).

HCMV is spread through bodily fluids including saliva, blood, breast milk, semen and urine and the majority of adults will be infected by HCMV at some point in their life. 

Once infected, the virus is carried within the person for life, but as long as people remain healthy, they rarely show any symptoms.

“However, HCMV can result in serious health complications and even death for those with weak immune systems, such as patients with HIV and organ transplant recipients,” said Dr Teng, an Associate Professor and Head of the Nanoelectronics Research Group at Swansea University, who will lead the work.

“It is a particular problem if caught by a woman during pregnancy, a problem affecting about one to two babies in every 200 in the UK. This makes it more common than Down’s Syndrome. 

“HCMV can cause permanent disabilities such as mental retardation, blindness, deafness, or even fatality, to infected babies.  Many are not diagnosed at birth because they do not show symptoms, however they can develop hearing or vision loss, or developmental problems, months or years later.

“Early detection of HCMV is critical to allow intervention as soon as possible, in order to minimise the long-term impact of these problems.”

This project allows the research and development of a new, non-invasive, low-cost, easy to use point of care diagnostic device, which can directly detect HCMV either in urine or saliva.

“Such novel technology is ideal for large-scale screening programs,” added Dr Teng. “For example it would become possible to screen all newborn babies for the virus, allowing targeted treatment even before symptoms are seen.

“We are very pleased with this prestigious award, as it allows us to develop an innovative invention that offers low-cost, easy-to-use, rapid detection of pathogens using nanotechnology.

“The invention is suitable for large-scale screening of viral infections with excellent sensitivity and specificity without the need to send the sample to laboratory.  This would enable early and effective treatment of the diseases.”    

The device can be manufactured using a printing technique, which offers low-cost high-volume production of the technology, to ensure commercial viability of the invention.  This is in collaboration with co-investigator Dr Davide Deganello, from the Welsh Centre for Printing and Coating (WCPC) at Swansea University.

Dr Richard Stanton said: “Up to 1,000 babies are born every year in the UK with permanent disabilities as a result of HCMV infection.  This project is a fantastic opportunity to combine expertise in virus infection at Cardiff University, viral diagnosis at the Wales Specialist Virology Centre, nanotechnology at Swansea University and printing at the WCPC to make a real difference to their quality of life.”

Welcoming the news of the grant award, Caroline Star, Chair of CMV Action, said: “We are very excited on this innovative project.  An early diagnosis of congenital HCMV is crucial to ensure that families can get the treatment and monitoring their babies need.  Sadly this often does not happen. 

“The families we represent feel strongly that more should be done to screen newborn babies for HCMV.  We hope this research will show how this can be done and help to limit the devastating impact of HCMV.”

Dr Vincent Teng and Dr Richard Stanton’s project idea was developed through the Welsh Crucible, an award-winning programme of personal, professional and leadership development for the future research leaders of Wales, which supports research-inspired innovation and cross-disciplinary collaboration in Wales.  Dr Teng and Dr Stanton were both awardees and participants of the Welsh Crucible in 2012. 


more about the national institute for health research


 more about the welsh crucible


 



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events