Dynamic Extractions are specialists in the field of Countercurrent Chromatography (CCC) which is a technique that is orthogonal and complementary to liquid-solid chromatographic techniques such as High Performance Liquid Chromatography (HPLC) and Flash chromatography.
Products HPCCC Intruments for liquid chromatography from milligrams to kilos:
Mini HPCCC instrument - Method development and small scale purification to 200 milligrams per injection
Spectrum HPCCC instrument - Method development and semi-preparative scale separations to 3 - 4 grams per injection
Midi HPCCC instrument - Method development and preparative scale separations to 30 grams per injection
Maxi HPCCC instrument - Preparative and pilot scale separations to 550 grams per injection
Off the shelf complete purification systems available for instruments to Midi size.
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In medicinal chemistry a challenging aspect to preparing compounds for testing, as lead molecules, can be their isolation from the crude reaction mixture that may contain catalysts, salts, metals, and other components which interfere with traditional purification methods. One such problematic compound is triphenylphosphine oxide (TPPO). TPPO is notoriously difficult and time consuming to remove using standard solid phase chromatography methods. In this example a standard HPCCC method has been developed that targets TPPO, regardless of the compound of interest's polarity...
In medicinal chemistry a challenging aspect to preparing compounds for testing, as lead molecules, can be their isolation from the crude reaction mixture that may contain catalysts, salts, metals, and other components which interfere with traditional purification methods. One such problematic compound is triphenylphosphine oxide (TPPO). TPPO is notoriously difficult and time consuming to remove using standard solid phase chromatography methods. In this example a standard HPCCC method has been developed that targets TPPO, regardless of the compound of interest's polarity...