Follow us on
Search News Archives
Conferences | Events
Monthly Newsletter
Lab Bulletin Media Partners

Horizon Discovery Edit-R crRNA Libraries Adopted by AstraZeneca

publication date: Oct 12, 2018
 | 
author/source: Horizon Discovery Group


Horizon Discovery Group plc, a global leader in gene editing and gene modulation technologies, announces that AstraZeneca has adopted its Edit-R™ crRNA libraries as part of AstraZeneca’s drive to establish a functional genomics discovery platform.

AstraZeneca also joins the Genomics Discovery Initiative (GDI), a collaborative functional genomics screening community facilitated by Horizon.

AstraZeneca has been evaluating Horizon’s Edit-R human whole genome crRNA library for gene knockout since late 2017, and will soon add the Company’s platform of arrayed synthetic crRNA libraries for CRISPR-mediated transcriptional activation (CRISPRa). The libraries offer a powerful tool for functional genomic screens in drug discovery, providing deeper insight into biological mechanisms for the purpose of understanding disease progression, host-pathogen relationships, drug interactions, and pathway analysis.

Horizon’s Edit-R CRISPR-Cas9 synthetic crRNA libraries for both knockout (loss-of-function) and activation (gain-of-function) enable whole genome analysis in an arrayed format, allowing researchers to carry out high-content, multiparametric analyses on a one-well-per-gene basis. The portfolio includes catalog libraries for popular human and mouse gene families, in addition to druggable gene targets and the whole human genome. Bespoke collections are also available to support researchers working with a specialized gene target list.

Terry Pizzie, Chief Executive Officer, Horizon Discovery, commented: “Our ongoing relationship with AstraZeneca is providing valuable insights into the scope and capabilities of CRISPR screening, which will be of benefit to the research and discovery community, ultimately bringing drugs to market faster.”

Steve Rees, Head of Discovery Biology, IMED Biotech Unit at AstraZeneca, said: “The scientific support and degree of collaboration with the scientists at Horizon has been really impactful in ensuring we are able to harness the full potential of the platform. We have been impressed with the performance of the Edit-R synthetic crRNA, and look forward to feeding our drug discovery pipeline with data generated from the CRISPRa crRNA libraries.”

Horizon’s Genomics Discovery Initiative brings together visionary research institutions and investigators, to serve as a network for education, trends, advancements, and sharing of best-practices. The Initiative has over 60 member institutes worldwide, has generated multiple shared publications, and hundreds of published whole genome siRNA screens.




 

Popular this month


Top Trends Changing The Medical Laboratory Industry In Europe
MtoZ Biolabs Releases Protein N-terminal Sequencing Technique
Discovery Park Unveils New Management Team

Control and monitor up to 50 cyclers from a central software application


Quantifying SF6 and PCBs with a custom-designed Nexis GC-2030


Differential Ion Mobility Interface Boosts Proteomics Workflow Performance


New Catalogue from Scientific Laboratory Supplies Ltd


Waters’ Empower software integrates Metrohm ion chromatography systems
Peak Scientific Underlines its Position as the Leader in Nitrogen Systems for Single Quad LC-MS
Chromatography Training from Hichrom

Can't find what you are looking for?


Search by company or by product


Company Name:

Product:





Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd