The demand for faster and more reliable cannabinoid analysis is growing with the expanding use of medicinal cannabis. Traditional HPLC methods often fall short in resolution due to the similar structures of cannabinoids. This application note presents a rapid UHPLC method using the YMC-Triart C18 ExRS column, delivering high-resolution separation of 11 cannabinoids in less than 6 minutes. Optimised for challenging separations, this column ensures efficiency without compromising accuracy...

SepSolve Analytical Ltd has launched Smart Subtract®, a powerful new tool that transforms how chromatographic data is compared. Identifying differences between ‘good’ and ‘bad’ batches has long been a time-consuming and labour-intensive process, often taking days or even weeks to yield meaningful insights. Smart Subtract reduces this to minutes while delivering more accurate results...

TESTA Analytical reports that its Differential Refractometer improves the precision of dn/dc determination using light scattering techniques. An accurate dn/dc value is essential in molecular weight determination of biopolymers and polymers by light scattering. Backed by decades of experience of Gel Permeation Chromatography (GPC) and Light Scattering techniques, Testa Analytical has created a differential refractometer accessory for light scattering instruments that deliver exceptional performance and is easy-to-use...

The world’s number one laboratory gas generator manufacturer¹, PEAK Scientific, has announced that its’ best-selling Genius range of nitrogen gas generators for LC-MS are now the first laboratory nitrogen generators to be certified with an Accountability, Consistency and Transparency (ACT®) Ecolabel from My Green Lab®. With this certification, laboratories with an active Genius product can access independently verified environmental impact data, covering key sustainability metrics related to manufacturing, energy and water use, packaging, and end-of-life considerations...

The requirements for quality assurance of biologics are increasing. Danish contract laboratory now opens for access to a database that - combined with the company’s measurement tools - can shorten the development time and heighten the quality of novel biological products. Since 2007, the contract laboratory Alphalyse A/S has developed and refined a new method of impurity analysis in biological pharmaceuticals based on mass spectrometry (MS)...

Bio-Rad Laboratories, Inc. a global leader in life science research and clinical diagnostics products, has announced the launch of Nuvia wPrime 2A Media, a scalable weak anion exchange and hydrophobic interaction (AEX-HIC) mixed-mode chromatography resin for small- to large-scale biomolecule purification. Bio-Rad's partners in the resin’s development successfully used the resin to remove host cell proteins, high and low molecular weight aggregates and impurities, and DNA from monoclonal and bispecific antibodies, and adeno-associated virus...

Labomatic Instruments AG and KNAUER Wissenschaftliche Geräte GmbH are pleased to announce a strategic cooperation aimed at combining their complementary strengths to offer a larger portfolio to their respective customer bases. Customers in the liquid chromatography segment in particular are likely to benefit from the complementary expertise, especially in terms of flow rate and pressure ranges...

Using the HPLC Pump Qualification Pack from TESTA Analytical considerably reduces the time required for HPLC pump qualification, while improving traceability of results. Comprising a calibrated non-invasive, realtime LC flowmeter, data validation tool and tablet-computer with pre-installed software – the pack automatically performs all necessary flow data calculations plus operational and performance qualification checks...

Advances in nanoparticle and protein development have introduced complex solutions with a narrow window for achieving optimal efficacy and safety. Addressing these challenges requires precise control over charge, size and distribution. The ZetaStar™️ instrument integrates dynamic, static and electrophoretic light scattering (DLS/SLS/ELS) measurements into a single system...

YMC Accura columns are the solution for researchers working with challenging phosphate-rich molecules or metal-coordinating compounds. These bioinert columns feature an advanced inert coating, designed to prevent peak tailing and carry-over, while delivering optimal recovery rates. Their seamless compatibility with MS detectors, as demonstrated in this technical note, ensures enhanced workflow accuracy, making them an indispensable tool for high-sensitivity applications...

Flow rate is one of the most important parameters in any liquid chromatography system, it determines retention time or volume and therefore has a major influence on reproducibility. In this new study, the TESTA Analytical Liquid Chromatography Flowmeter is shown to provide a valuable tool for continuous, non-invasive measurement of flow rate in GPC/SEC systems...

SepSolve Analytical (Peterborough, UK) has unveiled significant upgrades to its highly regarded BenchTOF2 time-of-flight mass spectrometer. Renowned for its high mass accuracy, exceptional spectral quality, and trace-level sensitivity, the BenchTOF2 now delivers even greater performance, solidifying its position as the ideal solution for non-target screening and demanding analytical applications...

Maximise efficiency and precision in the analysis of monoclonal antibodies (mAbs) and antibody-drug-conjugates (ADCs) with YMC's tailored solutions. This collection of applications combines proven reliability with cutting-edge technologies to optimise your workflows and save valuable lab time. From intact to fragmented mAbs, DAR determination, or native LC-MS techniques, YMC columns provide highly sensitive and reliable methods using ion exchange (IEX), size exclusion (SEC), hydrophobic interaction (HIC), and reversed-phase liquid chromatography (RP)...

Bio-Rad Laboratories, Inc., a global leader in life science research and clinical diagnostics products, has announced the launch of Foresight™ Pro 45 cm inner diameter (ID) chromatography columns, designed to support downstream process-scale chromatography applications across different stages of biological drug production. Expanding on Bio-Rad’s portfolio of Foresight Pro columns with inner diameters ranging from 5 to 33 cm, the new, larger 45 cm ID Foresight Pro Column offers biopharma manufacturers...

Biotech Fluidics reports that a major pharmaceutical customer has purchased 17 SPR-200 solvent recycler units to improve sustainable use of solvents by HPLC systems in their analytical laboratories. Externally powered, the standalone SPR-200 solvent recycler does not require an external computer thereby avoiding potential connectivity issues with user I.T systems. Compatible with most HPLC systems, the SPR-200 continuously monitors the output signal of liquid chromatography instrument detectors

FlowChrom from TESTA Analytical is an automated non-invasive, real-time monitoring system providing a continuous digital record of your HPLC system performance. While most HPLC and UHPLC are designed to operate 24/7, it is common for issues to arise when liquid chromatography systems are left unattended. In many instances, it is then difficult to understand what the source of the operating problem was and to determine when it occurred and how many HPLC separations were affected and must therefore be repeated...

On December 1st, 2024, a new general chapter will be available in the US Pharmacopeia (USP), which will provide biopharmaceutical developers with guidelines for mass spectrometry-based quantification of host cell protein (HCP) impurities in biologic drugs. With this, the medical industry stands on the threshold of a paradigm shift that could reduce unwanted side effects of biologics while clearing the way for more advanced products...

Waters Corporation announced the official opening of its new 45,000 square foot manufacturing facility at the Longbridge Business Park in the West Midlands. The new facility more than triples existing operations and enhances the company's machining capacity to produce critical components for products developed and manufactured at Waters Mass Spectrometry Center of Excellence in Wilmslow, UK and in Wexford, Ireland...