High-throughput, automated, dynamic and static light scattering 

Biopharma labs today face a growing challenge: more samples, less sample volume, more attributes to measure, and less time to train new staff. Development timelines are shrinking, and the pressure to deliver high-quality, reproducible data is higher than ever.

Scientists and lab managers need tools that keep pace with these demands — tools that simplify workflows, reduce troubleshooting, and support confident decision-making across teams.

That’s where the new DynaPro™ Plate Reader 4 platform from Waters | Wyatt makes a difference.

Built for High-Throughput, Multi-Attribute Analysis

The DynaPro Plate Reader 4 is designed for real-world biopharma workflows with scientists, technicians, managers, and technical leads in mind. It enables multi-attribute analysis of critical quality attributes (CQAs) such as aggregation, colloidal stability, and thermal stability — all from as little as 4 µL.

With dynamic and static light scattering (DLS and SLS), users can screen for size, molar mass, polydispersity, aggregates, viscosity, melting temperature T_m, aggregation temperature T_agg, the diffusion interaction parameter k_D, and second virial coefficient A₂ — in a single workflow.

Confidence in Every Run

Automated data quality rules and an onboard camera detect bubbles, dust, and particulates that could compromise results. This reduces troubleshooting time and ensures confidence in every run. Users can visualize entire data sets or zoom in on promising conditions for deeper analysis.

Walk-Up Usability and Automation-Ready Integration

The DYNAMICS Touch™ interface provides guided workflows and real-time feedback, making it easy for junior scientists to execute experiments and for senior technicians to train others. The system integrates seamlessly with liquid and plate handlers from Hamilton, Tecan, HighRise, LabMate, and Andrew+ via a robust software API.

Flexible, Scalable, and Compliance-Ready

The Plate Reader 4 supports industry-standard 96, 384, and 1536 well plates, offering supply chain flexibility and cost savings. Sample metadata is integrated into the analysis workflow, and a 21 CFR Part 11 compliant security pack will be available in early 2026. Remote operation and monitoring support collaboration across teams and locations.

Expert Support and Training

Backed by over 30 years of light scattering expertise, Waters | Wyatt offers in-depth training through Light Scattering University™. From method development to troubleshooting, Waters | Wyatt’s applications and engineering teams are accessible, knowledgeable, and committed to your success.

Conclusion

The DynaPro Plate Reader 4 helps labs overcome today’s bottlenecks with confidence. Whether you're scaling up assays, training new staff, or preparing for regulatory submission, it delivers the data quality, usability, and flexibility your lab needs to succeed.

Simplify and accelerate your workflows with walk-up or automated high-throughput sizing, stability, and particle concentration. Discover the DynaPro Plate Reader 4.

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