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Study Finds Merck Millipore's Strat-M Synthetic Membrane Comparable to Human and Animal Skin for Permeation Studies

publication date: May 28, 2015
 | 
author/source: Merck Millipore

Merck Millipore, the Life Science division of Merck, announced publication of a study showing that its Strat-M® synthetic membrane predicts skin permeation of chemical compounds during in vitro transdermal diffusion studies as effectively as human or animal skin.

merck millipore

The study was conducted by researchers at Josai University in Japan and published in the January 25, 2015 issue of European Journal of Pharmaceutical Sciences.

 

  • Results showed similar permeability coefficients for human skin, rat skin and Strat-M ® membrane 

  • Demonstrated Strat-M® membrane is an effective alternative to use of animal or human skin for permeation studies

  • Ideal for transdermal diffusion testing for a wide range of pharmaceutical and cosmetic compounds

 

Strat-M® membrane is a synthetic, non-animal-based model that is predictive of diffusion in human skin for a wide range of compounds and formulations, including active pharmaceutical ingredients, cosmetic actives, personal care products, pesticides and other chemicals. The membrane provides highly consistent, reproducible diffusion data without the lot-to-lot variability that often occurs with biological models.

The new study evaluated the ability of Strat-M® membrane to serve as an alternative to human and animal skin for estimating the skin permeability of different chemical compounds. Thirteen compounds were tested on excised human skin, hairless rat skin and Strat-M® membrane. Permeability coefficients obtained with Strat-M® membrane could be used to predict those obtained from the human and rat skins.

"In vitro skin permeation studies are essential to development of new transdermal delivery systems," said Kenji Sugibayashi, Ph.D., author of the study, Professor of Pharmaceutical Sciences at Josai University, and renowned expert on skin permeation. "Biological models are often used to conduct this research, but there are various drawbacks, including high variability, low availability, safety considerations and storage limitations." Study coauthor Dr. Hiroaki Todo added, "Our study suggests that Strat-M® membrane can serve as an alternative to human and animal skin in permeation studies, offering researchers a valuable tool for screening candidate compounds."

"Drs. Sugibayashi's and Todo's peer-reviewed research confirms that Strat-M® membrane can be used for transdermal diffusion testing," said Patrick Schneider, Ph.D., Head of Bioscience at Merck Millipore. "Published results supporting the membrane's application will increase awareness and accelerate adoption by the research community, facilitating in vitro testing of transdermal formulations."

Introduced in 2012, Strat-M® membrane is constructed of multiple layers, creating morphology similar to human skin. Strat-M® membrane is individually packaged as precut discs that are easy to store and do not need to be hydrated prior to use.


more about merck millipore


 



 

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