Follow us...


Search News Archives

News Channels


Coronavirus (COVID-19)


View Channel

New Laboratory Products


View Channel

Lab News


View Channel

Research & Case Studies


View Channel

Microscopy | Image Analysis


View Channel

Separation Science


View Channel



View Channel

Events | Webinars


View Channel

Conferences | Events

USP monograph modernization: Chemical medicines assay by potentiometric titration

publication date: Dec 5, 2018
author/source: Metrohm AG


USP and Metrohm jointly developed a potentiometric titration method for potassium bicarbonate and potassium carbonate assay.

The new method uses autotitration combined with suitable equivalence point detection fulfilling all USP method validation requirements as per USP General Chapter <1225>

Many of the chemical medicine assay procedures are done by manual titration as per USP monographs. The manual titration procedure lacks data integrity and is prone to human error.The new method developed in a collaboration between USP and Metrohm addresses these shortcomings. It utilizes autotitration combined with suitable equivalence point detection. Users benefit from more convenience, better reliability, and increased specificity. For high throughput needs, the new method can be easily automated.

However, autotitration combined with appropriate equivalence point detection methods not only eliminates manual errors but fulfills data integrity and 21 CFR Part 11 requirements, which makes the pharmaceutical QA/QC workflow easier. The new method offers selectivity and fulfills all USP method validation requirements as per USP General Chapter < 1225>.


Download poster

more from metrohm

If you have not logged into the website then please enter your details below.



Popular this Month...

Our Top 10 most popular articles this month


Today's Picks...




Looking for a Supplier?

Search by company or by product


Company Name:




Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd



Media Partners