Automated Density Gradient Preparation Reduces Run Times by up to 75%

Beckman Coulter Life Sciences, a Danaher company and a global leader in laboratory automation and innovation, announces the launch of the OptiMATE Gradient Maker, a groundbreaking instrument designed to automate the process of density gradient ultracentrifugation (DGUC). The new system accelerates purification processes by up to 75% while improving consistency and reproducibility.
 
Current upstream workflows can take up to 3 days with time-consuming steps including stock preparation, mixing and dispensing, along with tube sealing and up to 48-hours for spinning. The OptiMATE Gradient Maker slashes that to as little as 6 hours with 4 simple steps from method creation, connecting consumables, method running, and spinning. The spin process alone shrinks from up to 48 hours to less than 5 hours by dispensing pre-formed linear gradients which dramatically reduces centrifuge run times.
 
“This innovation offers a major breakthrough to expedite purification workflows,” said Shawn Sternisha, Global Commercial Product Manager. “By automating the complex and time-consuming gradient preparation, we’re uniquely able to help laboratories dramatically reduce tedious, error-prone manual steps while improving the consistency and reproducibility of their results. This advancement not only drives efficiency, but also ensures high-quality outputs which are essential for a wide range of applications.”
 
The OptiMATE Gradient Maker, for research use only (RUO), is ideal for the purification of viral vectors such as adeno-associated virus (AAV). The system simplifies the process of preparing ultracentrifuge-ready tubes, allowing researchers to achieve high-purity results with minimal manual intervention. Its plug-and-play design makes it easy to integrate into existing lab setups without requiring extensive training, providing a user-friendly solution for busy research environments.
 
Intuitive software with a user-friendly design enables operators to be trained in a matter of hours versus weeks, all in a compact and space-saving benchtop design.
 
“The OptiMATE Gradient Maker is designed to meet the growing demand for faster, more consistent purification,” said Balasubramanian Venkatakrishnan, Senior Application Scientist. “By unleashing the benefits of automation to critical steps in gradient preparation, we’re enabling labs to obtain high-quality results more quickly and with less variability. This is a key benefit for researchers focused on high-throughput purification and those looking to improve efficiency in their workflows, empowering their next big discovery.”
 
The OptiMATE Gradient Maker will make its debut at the American Society of Gene & Cell Therapy (ASGCT) in booth 527 May 13-17, 2025 in New Orleans, LA.

This product is not intended or validated for use in the diagnosis of disease or other conditions.

About Beckman Coulter Life Sciences

Time is the most critical facet in the laboratory today:  time to get life-saving therapies to patients faster; reclaiming time by automating tedious manual workflows; and saving time otherwise spent addressing erroneous or complex results.
 
At Beckman Coulter Life Sciences, a Danaher company, we are partners in time. We accelerate answers to critical questions through the power of efficiency, saving hours from some workflows and delivering reliable results in centrifugation, flow cytometry, genomic solutions, particle analysis/counters, and liquid handlers.
 
We develop innovations for scientists by scientists, with many of our 3,300+ global colleagues coming from the laboratory with a deep understanding of today’s challenges and complexities. We’re passionate about translating science in partnership with our customers, and our customizable, accessible and sustainable solutions empower them with intuitive workflow efficiencies.
 
Time and again customers put their trust in us, with 400,000+ of our built-to-last products currently delivering results in labs worldwide – all backed by our dependable service and application experts offering educational insights and tailored support.
 
It’s all part of our time-tested approach since 1935 to bring meaningful innovations at the speed of life—and we’re just beginning. Working together, let’s advance human health for a better tomorrow!
 

 
About Danaher

Danaher is a leading global life sciences and diagnostics innovator, committed to accelerating the power of science and technology to improve human health. Our businesses partner closely with customers to solve many of the most important health challenges impacting patients around the world. Danaher's advanced science and technology - and proven ability to innovate - help enable faster, more accurate diagnoses and help reduce the time and cost needed to sustainably discover, develop and deliver life-changing therapies. Focused on scientific excellence, innovation and continuous improvement, our approximately 63,000 associates worldwide help ensure that Danaher is improving quality of life for billions of people today, while setting the foundation for a healthier, more sustainable tomorrow.

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