BioChromato Inc. reports on how Pharmaceutical companies undertaking Absorption, Distribution, Metabolism and Excretion (ADME) studies are benefiting from integrating RAPID Easy Piercing Seals (EPS) into their screening protocols. Optimization of the ADME properties of a drug molecule is one of the most difficult and challenging part of the drug discovery process. The ADME profile of a compound has a major impact on the likelihood of its success as a drug....

Waters Corporation (NYSE:WAT) today announced that its Xevo TQ-XS atmospheric pressure gas chromatography (APGC) mass spectrometry (MS) platform is an accepted alternative for the identification and quantification of dioxins and furans in environmental samples. Dioxins are a byproduct of human industrial activity and their effects on human health are well documented....

BioChromato Inc. has published an interview with the Department of Medicinal Chemistry and Molecular Pharmacology at Purdue University (Indiana, USA) that explains how the Smart Evaporator C1 has assisted them in isolating and purifying novel compounds from DMSO solutions for potential pharmaceutical use. Because the US Federal Drug Administration (FDA) does not approve DMSO formulations for human administration, researchers at Purdue University wanted to synthesise a new Platinum (IV) chloride complex...

In this application note the drug-to-antibody ratio (DAR) of a cys-linked ADC-mimic is determined using online native HIC-MS. Using the innovative BioPro HIC BF column and a direct coupling to the mass spectrometer even degraded payloads can be detected. The application also demonstrates how to overcome the high salt concentrations which are necessary for HIC methods....

Excellims Corporation (Excellims), a leading provider of high performance ion mobility spectrometers (HPIMS) / mass spectrometry (MS),  has won The Analytical Scientist Innovation Award (TASIA) 2020. TASIAs showcase the technologies driving progress in measurement science. The award recognizes that HPIMS brings the power of state-of-the-art Ion Mobility out of the lab: enabling high resolution and sensitive chemical detection at the point of need...

Cell Guidance Systems Ltd, a specialist in exosome research reagents and services, has announced the launch of a new product for the purification of exosomes from blood and other samples. The Exo-spin™ 96 exosome purification kit allows researchers to purify exosome samples in the standard 96 well plate format. The Exo-spin 96 kit is based on the increasingly popular size exclusion chromatography (SEC) method of exosome purification which is now used by most exosome research labs....

TESTA Analytical Solutions has published a technical report that evaluates an exciting new liquid flowmeter device designed to provide continuous real-time monitoring of the pump flow rate of any liquid chromatography system. High Performance Liquid Chromatography (HPLC) is nowadays one of the most widely used techniques in analytical chemistry. The range of applications soluble using HPLC covers a vast range of sample types, concentrations and compositions....

The Differential Refractive Index (DRI) detector from Testa Analytical Solution e.K offers unmatched accuracy and reliability for determination of absolute concentration and total mass balance in Gel Permeation Chromatography / Size Exclusion Chromatography (GPC/SEC) applications. The baseline signal stability of any liquid chromatography detector is very important, as it is a limiting factor in peak determination....

Agilent Technologies Inc. has announced a new ICP-MS instrument, the Agilent 7850 ICP-MS System, that provides new smart tools to minimize common time traps that can affect ICP-MS analysis workflows.Building on decades of innovation, the 7850 ICP-MS combines market-leading performance with new smart software features that bring advanced capabilities to the routine ICP-MS laboratory....

A new inductively coupled plasma mass spectrometry (ICP-MS) instrument has been designed to enable scientists working in earth sciences, nuclear safeguards and biomedical research to conduct reliable, high-precision isotope ratio analysis across a wide range of applications, without compromising sensitivity, stability or ease-of-use. The Thermo Scientific Neoma Multicollector ICP-MS (MC-ICP-MS) system combines innovative features from the field-proven technology...

Save 15% on Supelco GC columns for use with the Agilent^® Intuvo^® GC System. We know the importance of having options for your Gas Chromatography analysis, that is why Supelco^® has developed the first GC column alternatives for use with the Agilent^® Intuvo^® GC system.  From the workhorse SLB – 5cms and the unique selectivity ionic liquid columns to speciality columns like the Chiraldex® column, you now have a full portfolio of alternatives to choose from....

Okadaic acid is diarrhetic toxin (DSP) which can be found in shellfish. Due to its inhibitory effects towards specific protein phosphatases it is a promising compound for various potential medical uses. This application note shows the LC-MS/MS analysis of okadaic acid and its derivates with different YMC-Triart phases. All phases are suitable for the separation of these compounds with high resolution....

Greyhound are offering a 20% discount off all SGE/Trajan gas filters and base plates until December 11th 2020, plus FREE DELIVERY on orders for 3 or more filters/base plates. Gas purifiers are an essential part of your GC analysis as contaminants in gases can significantly impact on the quality of results.  Oxygen, hydrocarbons and moisture can lead to problems such as noisy baselines, moisture entering the GC column, excessive bleed and septa degradation....

RAPID EPS seals from BioChromato Inc. are designed for scientists looking to prevent contamination issues and autosampler needle clogging when accessing samples stored in 96-well microplates ready for LC/MS analysis. For LC/MS users, a key criterion for an effective microplate seal is its resistance to solvents such as Acetonitrile, Methanol and DMSO which are commonly used in experiments and analysis....

Agilent Technologies Inc. has announced a collaboration with SGS has resulted in a new GC/TQ method, the SGS AXYS Method 16130, approved by the US EPA as an alternative method for the future regulation and detection of dioxins. Dioxins are a group of chemical compounds that are considered persistent environmental pollutants and subsequently find their way into the food chain....

In some methods derived from the Pharmacopoeia the stipulation of a specific injection solvent can lead to issues with peak shape and a reduced sensitivity for some or all compounds analysed. With a custom injection program, you can overcome this hurdle and still be conform to Pharmacopoeia guidelines. Your gain will be a higher chance to achieve your system suitability criterions and a more reproducible and robust analysis...

Peak Scientific, the global leader in gas generation systems for analytical laboratories, was awarded ‘British Exporter of the Year’ at the 2020 British Business Awards held at the Shanghai Jinjiang Tomson InterContinental Hotel on the evening of October 29th. This is Peak Scientific’s second BBA accolade, after winning Best New Exporter to China award in 2016. The newly-appointed British Ambassador to China and Patron of the BBA 2020, Caroline Wilson CMG attended the awards dinner and delivered a speech....

Thermo Fisher Scientific, the world leader in serving science, and the Biopharmaceutical Analysis Training Laboratory (BATL) at Northeastern University, have entered into a collaborative agreement in a bid to advance analytical capabilities and drive innovation across the biopharmaceutical industry in areas including personalized medicine, monoclonal antibodies and gene and cell therapies....

Tecan and ProtiFi have partnered to create an integrated, highly scalable and easy-to-use proteomics workflow powered by the ProtiFi S-Trap™ sample preparation system and the Tecan Resolvex® A200 automated positive pressure workstation. The combined solution enables researchers to reproducibly prepare samples of all types for mass spectrometry-based proteomics.