The live launch of Malvern Panalytical's Morphologi 4 and Morphologi 4-ID. February 14th 2 PM GMT / 9 AM EST. Be the first to learn about the new Morphologi 4 Range of automated static imaging systems - designed to help you understand and optimize your processes and particulate samples by delivering robust and reproducible insight into particle size, shape and chemical ID...

The new MicroCal PEAQ-DSC microcalorimeter from Malvern Instruments resets the performance standard for characterizing protein and biomolecule stability.

This latest innovation in Differential Scanning Calorimetry (DSC) has been created specifically for the regulated environment and delivers essential data to guide biopharmaceutical development, from protein engineering, through pre-formulation and process development, to formulation and manufacture of the final product. The new system offers developers a quick stability assay to identify biotherapeutics with good stability potential and enables them to determine...

Leading Industry Experts Gather for Malvern MicroCal Open Forum Meetings in Europe and the US

Leading microcalorimetry experts from across the globe will be joining Malvern MicroCal scientists at open forum meetings in Europe and the USA that provide a valuable opportunity for scientists to extend their understanding and application of this powerful analytical technique. Microcalorimetry enables detailed investigation of the interactions between and thermodynamics of molecules/biomolecules...

Malvern Instruments has launched the new Zetasizer AT, a robust, online, automated analyzer that uses dynamic light scattering (DLS) to automatically measure the size of nanoparticles in suspensions and emulsions.

The new analyzer provides timely and reliable data that enables tracking of processes in the sub-micron size range, such as emulsification, dispersion, milling and homogenization, while at the same time eliminating the delays and inefficiencies associated with manual analysis....

Experts from Nanopharm, supported by Malvern instruments and with funding from the Food and Drug Administration (FDA), have carried out experimental studies to identify analytical strategies that can help bring generic nasal sprays to market faster.  

The findings, presented at Respiratory Drug Delivery (RDD) 2016, describe the benefits of applying component-specific particle size measurement and rheological characterization to determine the Critical Material and Process Attributes of suspension nasal sprays.  By supporting fast and robust bioequivalence testing, these techniques add value in the development of abbreviated new drug applications...

Researchers working on the European Metrology Research Project NanoChOp (Chemical and Optical Characterization of Nanomaterials in Biological Systems), funded by EURAMET, have concluded that the NanoSight Nanoparticle Tracking Analysis system from Malvern Instruments offers unique insight into the behavior of nanoparticles in biological systems.

Such insight supports ongoing efforts to assess the potential risks to human health posed by the increasing use of nanomaterials. Dorota Bartczak, Researcher in Inorganic Analysis at LGC commented that ”Measurement methods and techniques that provide reliable data for researchers to understand how nanoparticles behave in complex biological systems are crucial for the human risks assessments needed to ensure that the...

Data measured using the NanoSight NS300 from Malvern Instruments is providing new insights into the role of exosomes in diseases such as cancer, arthritis, Alzheimer’s disease and cystic fibrosis, in pioneering research at the University of Alabama - Birmingham (UAB).

“Early research on exosomes, or extracellular vesicles, focused on their role in excreting unwanted waste from cells,” said Shawn Williams, facility manager and imaging specialist. “However, we’re now starting to understand their wider functionality in intercellular communication and the transmission of disease. The NanoSight system is playing a central role in helping us advance in this new and exciting area of research, by...

Researchers at The Institute of Petroleum Engineering at TU Clausthal in Germany are being supported by Malvern Instruments in new work to understand and optimize the performance of Enhanced Oil Recovery (EOR) fluids.

The polymeric solutions used for EOR exemplify the fluids used in a range of drilling applications to maximize oil extraction while at the same time safeguarding geological formations. Details of the work have recently been presented in a new webinar which is available for download/viewing. EOR involves injecting a solution into the porous rock surrounding a well and can boost the amount of oil extracted by up to 20%...

The latest software release along with an expansion of the global technical specialist team, highlight Malvern Instruments’ ongoing commitment to extending and supporting the application of NanoSight, a nanoparticle characterization technology with unique capabilities.

The Malvern NanoSight range enables the visualization, sizing and counting of nanoparticles, exosomes, protein aggregates, and is increasingly being used in biopharma and nanoparticle research. “Two years on from joining Malvern, the benefits of becoming part of a larger global business are clear. NanoSight customers are now benefiting directly from Malvern’s highly developed skills in making complex analytical techniques more...

A collaboration between Malvern Instruments (Malvern, UK) and Bio-Rad (Hercules, California) has delivered new analytical tools for the rapid identification of unknown particles.

New software to support Malvern’s Morphologi G3-ID, which analyzes particle size, shape and chemical composition, enables the direct comparison of measured Raman spectra with reference spectra in the extensive database of Bio-Rad’s market-leading KnowItAll® software. The result is powerful, robust particle identification capabilities for scientists working in forensic analysis and pharmaceutical/biopharmaceutical development who are...

Malvern Instruments have released new accessories for the Mastersizer3000 which optimize  the particle size analysis of chocolate and coffee.

The two new, innovative additions to the Mastersizer portfolio – Chocosizer and the Funnel Sample Feeder for the Aero S - enable faster analysis and make it easier to develop and apply the robust particle sizing methods that are essential to both industries. Particle size directly impacts both the flavor and strength of coffee. Consistent production of the correct grade of coffee therefore relies heavily on the quick and reproducible...

At the 29th Annual Symposium of The Protein Society (22-25th July, Barcelona, Spain) Natalia Markova, Principal Scientist- MicroCal, Malvern Instruments, will be presenting a workshop on how to enable high resolution protein interaction analysis using the latest MicroCal PEAQ-ITC system. 

Studies of biomolecular interactions are fundamentally important in all areas of the life sciences since such interactions drive and regulate all biological processes. To register for the workshop which will include a complimentary lunch please go to: http://www.malvern.com/protein2015. The workshop will address current challenges scientists face in interaction analysis through a Q&A panel session with calorimetry experts. A subsequent...

A series of highly interactive 2-day seminars delivered by Malvern Instruments, which encompassed expert presentations and ‘up close’ practical workshops showcasing the latest in nanoparticle characterization technology, have been widely praised by attendees.

Feedback from delegates to the ‘Latest Methods in Nanoparticle Characterization’ events, which took place in various locations across the USA, Canada, Mexico and Brazil from April through to June, confirmed especially an appreciation of the detailed presentations about different characterization technologies and their applications, and the value of being able to participate in live instrument demonstrations. The seminars were presented as part...

Malvern Instruments has launched a new system based around Taylor Dispersion Analysis (TDA) to provide researchers with a novel orthogonal technique to accelerate biopharmaceutical drug candidates through the development pipeline.

The Viscosizer TD speeds up stability and formulation studies by offering unique solution-based molecular sizing capabilities, combined with relative viscosity measurement. Ultra-low sample volumes, fully automated measurement protocols, and precise environmental control for sample storage and measurement further enhance the value of the new system for early developability screening. TDA is a microcapillary flow-based technique that...

Seattle’s Hub for Industry-Driven Nanotechnology Education (Seattle, USA), an imaginative educational body with a flexible and highly productive model for nanotechnician training, has identified dynamic light scattering particle sizing as an essential analytical technique, investing in a Zetasizer Nano from Malvern Instruments.

“At SHINE we train the next generation of technicians to directly meet the needs of the nanotechnology industries in the Pacific North West,” said Peter Kazarinoff, Managing Director of SHINE. “A vital part of this is giving our students access to the analytical techniques and systems that they will use when employed.  The simplest reason we chose a Zetasizer Nano is that it is the instrument most widely used for nanoparticle and protein size...

Chromatography specialists from Malvern Instruments will present a reliable optimized solution for lignin characterization at a series of upcoming conferences in 2015, the first of which is Nordic Polymer Days, Denmark, June 1 – 3.

Lignin is a vital industrial polymer but presents significant challenges when it comes to measurement of the properties that define its performance. Through experimental study Malvern has identified the best strategy to apply when using gel permeation/size exclusion chromatography (GPC/SEC) to secure reliable information. The results of this work will also be presented at the 13th Annual UNESCO/IUPAC Conference on...

The unrivalled performance of OMNISEC, Malvern Instruments’ new gel permeation chromatography/size exclusion chromatography (GPC/SEC) system, is demonstrated in a series of recently released application notes which highlight the sensitivity of the system in synthetic polymer analysis. 

The OMNISEC platform brings together highly efficient and precise sample separation in the OMNISEC RESOLVE module with a fully integrated, high sensitivity multi-detector array in the OMNISEC REVEAL module. A complete OMNISEC system delivers the accurate molecular weight and molecular size measurements and detailed structural information needed to drive synthetic polymer research. The polymer industry is actively engaged in developing...

A brand new online edition of a highly popular book that reviews third party papers on the applications and usage of Nanoparticle Tracking Analysis (NTA) is now available from Malvern Instruments.

Malvern Instruments will showcase their expanding range of products for the life science and industrial sectors at ACHEMA 2015.

The four-day event (15-19 June) being held in Frankfurt, Germany will be the first major European outing for the latest additions to Malvern’s recently acquired MicroCal microcalorimetry range and for the innovative OMNISEC GPC/SEC platform. Visit the Malvern stand in Hall 4.1, stand number D59. Malvern’s products for life scientists provide information to drive drug discovery and development. Center stage will be the recently...

New research from the University of Padova in Italy shows how the Zetasizer Nano S, a nanomaterial and molecular characterization system from Malvern Instruments, is supporting the development of soluble carbon nanotubes (CNTs).

CNTs exhibit unique electronic, optical, mechanical and structural properties and are emerging as potentially important for a number of industrial applications including organic photovoltaic cells. One of the benefits of using soluble CNTs is that they are amenable to solution-based, low-cost, commercial manufacturing methods. The Zetasizer Nano is proving to be an easy-to-use tool for tracking and optimizing the functionalization reactions...

The ground-breaking sensitivity of Malvern Instruments’ new OMNISEC gel permeation chromatography/size exclusion chromatography system generated significant excitement from scientists meeting at the Seventh International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-7), when the system made a well-received debut late in January.

“Delegates were particularly enthusiastic about OMNISEC’s sensitivity,” said Paul Clarke, Industrial Portfolio Manager at Malvern Instruments. “Announcing ‘the most sensitive light scattering detector on the market’ is one thing but seeing what that actually means in practice is another. Demonstrations of the system measuring the molecular weight (MW) of a 100,000 Da Polystyrene standard with just a 100 ng of sample made a big impression and...

All new data analysis software in Malvern MicroCal PEAQ-ITC systems delivers greatest accessibility to life science users at every level 

Malvern Instruments has launched two new-generation isothermal titration calorimeters (ITC), advancing its recently acquired MicroCal range to further support life science researchers studying biomolecular interactions. The new manual Malvern MicroCal PEAQ-ITC and fully automated Malvern MicroCal PEAQ-ITC Automated systems are designed to deliver the enhanced functionality and robust performance now demanded of...

A new whitepaper from Malvern Instruments provides detailed guidance on the analytical technologies that help to accelerate oral solid dosage (OSD) product formulation to a successful conclusion.

‘Analytical techniques with a place in the oral solid dosage formulation toolkit’ reviews the regulatory and QbD framework associated with OSD formulation and demonstrates how Malvern systems can be used to generate the data required. The goal of formulation is to incorporate an identified drug substance into a successful pharmaceutical product. The regulatory framework for OSD products highlights the need to comprehensively...

As part of its rapidly expanding range of analytical tools for materials characterization, Malvern Instruments will showcase a new chromatography system and detectors at Pittcon 2015 (Mar 8^th – 12^th, New Orleans, USA). New additions to Malvern’s recently acquired MicroCal microcalorimetry range will also be on display.

The new systems will be shown alongside the Mastersizer 3000 laser diffraction particle size analyzer, complete with its recently introduced HydroSight imaging and Hydro SV small volume liquid dispersion accessories. Visitors can also explore nanoparticle characterization with the Zetasizer Nano and NanoSight Nanoparticle Tracking Analysis (NTA) systems, and morphological and chemical characterization with the Morphologi G3-ID, also...

A completely new gel permeation/size exclusion chromatography (GPC/SEC) platform from Malvern Instruments breaks new ground in delivering the high performance, ease of use and productivity demanded in today’s analytical laboratories.

Malvern’s innovative OMNISEC platform integrates highly efficient sample separation via the OMNISEC RESOLVE module and high sensitivity analysis using OMNISEC REVEAL, a fully integrated multi-detector array. The system has applications wherever there is a need for detailed analysis and understanding of natural or synthetic polymers, proteins and macromolecules. GPC/SEC is a two-step analytical process that involves separating a...

A new whitepaper from Malvern Instruments on Oral Solid Dose (OSD) deformulation demonstrates how the analytical technique of Morphologically Directed Raman Spectroscopy (MDRS) can be used to accelerate the development of generic products to a successful conclusion.

Deformulation, the unpicking and investigation of a reference labeled drug (RLD), enables generic developers to understand the features of a product that define its clinical performance. “Accelerating the deformulation workflow for oral solid dosage forms” reviews the current regulatory landscape associated with generic development and considers the workflow for preparing OSD product Abbreviated New Drug Applications (ANDAs)...

Researchers at the University of Lethbridge, Alberta, Canada, are using Viscotek multi-detector Gel Permeation/Size Exclusion Chromatography (GPC/SEC) (Malvern Instruments, UK) to analyze performance defining polymer features in the development of novel polymer coatings for metal nanoparticles.

“Multi-detection GPC/SEC helps us to monitor and control reaction conditions to engineer advanced polymer coatings which stabilize nanoparticle suspensions to ease their handling and preserve their industrial value,” said Dr. Farhad Faghihi, Research Associate at the University of Lethbridge. “GPC/SEC is the only technique that we have to determine molecular weight and molecular weight distribution with the speed and accuracy...

Alon Vaisman, Product Development Manager for Process Systems at Malvern Instruments, will speak about two quite different analytical techniques and their applications as part of the ‘Particle Characterization’ session at this year’s IFPAC® (International Forum on Process Analytical Technology and Quality by Design) Annual Meeting.

In separate presentations he will discuss the ‘Applications of Dynamic Light Scattering as PAT for on-line nano-particle characterization’ and ‘In-situ monitoring of high shear and fluid bed processing using spatial filter velocimetry’. Both address areas of growing emphasis in pharmaceutical production. The continuing importance of large molecule based therapeutics, and the drive to reduce the particulate size of small molecule APIs, is bringing new challenges for...

An automated dynamic light scattering system from Malvern Instruments has become established as an essential part of the analytical toolkit used by SARomics Biostructures AB, a leading provider of protein 3D structure determination and structure-based drug design services.

The Zetasizer APS automated plate sampling system is supporting the systematic study of the aggregation behavior of proteins, a fundamental component of the services provided by SARomics Biostructures. The company, which is based in Lund, Sweden within the biotech cluster of the Medicon Valley, is a research-intensive organization with clients around the world. The Zetasizer APS is a robust, simple-to-operate system that uses laser light scattering to determine a number of parameters associated...

A Morphologi G3-ID particle characterization system from Malvern Instruments is opening cutting-edge research opportunities in environmental science at the School of Science, Environment and Engineering, Southern Cross University (SCU), in Australia.

The Morphologi G3-ID, which is sold and supported in Australia by ATA Scientific, combines automated particle imaging with Raman spectroscopy to deliver particle size, morphology and chemical identification of particles within a dispersion. The technique is helping users to better understand the composition and behavior of natural particles within the environment and is generating substantial cost and efficiency savings in areas that...

Malvern Instruments has released new guidance on using automated image analysis to detect and quantify agglomerates.

The ability of uncontrolled agglomeration to substantially impact the performance and value of powder products makes efficient agglomerate detection vital across a number of industries. ‘Identification of agglomerates using automated image analysis’ presents practical strategies for efficiently and robustly differentiating agglomerates from primary particles, to support product development, QC and process troubleshooting....

‘Extending the boundaries of QbD’, a new whitepaper from Malvern Instruments, explores the application of Quality by Design (QbD) principles to the development of analytical instrumentation and the benefits this brings for users.

Taking the example of Malvern’s development of the Mastersizer 3000 particle size analyzer, the authors illustrate how instrument companies are aligning with the QbD philosophy. This offers pharmaceutical customers the reassurance of closely similar working practices and products that meet exacting customer standards. The central idea of QbD is that quality should be built into a product from the outset. It is an approach based on...

An automated dynamic light scattering system from Malvern Instruments has become established as an essential part of the analytical toolkit used by SARomics Biostructures AB, a leading provider of protein 3D structure determination and structure-based drug design services.

The Zetasizer APS automated plate sampling system is supporting the systematic study of the aggregation behavior of proteins, a fundamental component of the services provided by SARomics Biostructures. The company, which is based in Lund, Sweden within the biotech cluster of the Medicon Valley, is a research-intensive organization with clients around the world.

The new Mastersizer 3000 Hydro SV small volume liquid dispersion unit delivers reliable particle size measurement using just a few milligrams of sample.

Particle size is a performance-defining parameter for many industrial products. The ability to measure small samples sizes becomes crucial when sample availability prevents the use of larger amounts of material. This is especially true during early stage product development, for example. By minimizing sample and dispersant use the Hydro SV also reduces the development, purchase and disposal costs associated with routine analysis. Efficient sample dispersion...

Researchers at the School of Engineering and Materials Science, Queen Mary University London (QMUL), are using a Malvern Instruments Zetasizer Nano to provide particle size and charge data that is being used in the development of innovative hydrogel matrices for 3D cell culture.

The Zetasizer Nano’s high performance electrophoretic light scattering capabilities are allowing researchers to better understand the nature of the electrostatic interactions between proteins and peptides. These measurements are crucial to developing bespoke cell culture platforms for the production of specific biologically significant hydrogel. By creating hydrogel structures based on the charge of target biomolecules, researchers at QMUL aim to...

Malvern Instruments will demonstrate how the Kinexus rotational rheometer and Mastersizer 3000 laser diffraction particle sizing system enable smarter, faster and more effective strategies for food development at FoodTech Processing & Packaging.

The conference takes place at MCH Messecenter Herning, Denmark, from 28 to 30 October 2014. Malvern’s food characterization experts will be on hand throughout the event to demonstrate the analytical strategies that help R&D and QC scientists develop high performance products with enhanced consumer appeal. Visit Malvern on stand M9912....

Malvern Instruments will contribute a scientific poster at the 2014 Protein-Protein Interaction Conference, October 23-24, Boston, MA, USA.

The poster describes new work on rheological approaches to protein stability studies during biologics formulation and will be presented by Matt McGann, Malvern Instruments Life Science Sales and Application Specialist for the Americas. The study of rheology in protein formulation and biotherapeutic development is considered to be a developing and ultimately essential measurement. The Malvern presentation ‘Characterizing the stability of...

As Mastersizer 3000, the world-leading laser diffraction particle size analyzer, celebrates its 3^rd birthday, Malvern Instruments is delivering even smarter particle sizing with the launch of two new additions to the Mastersizer portfolio.

Join Malvern’s live web event on 9 October

Malvern Instruments will contribute a scientific poster at the 2014 Protein-Protein Interaction Conference, October 23-24, Boston, MA, USA.

The poster describes new work on rheological approaches to protein stability studies during biologics formulation and will be presented by Matt McGann, Malvern Instruments Life Science Sales and Application Specialist for the Americas. The study of rheology in protein formulation and biotherapeutic development is considered to be a developing and ultimately essential measurement....

The cross-disciplinary capabilities of Malvern Instruments’ technology are being fully exploited at Queen Mary University London.

The Zetasizer Nano, NanoSight Nanoparticle Tracking Analysis (NTA) and Mastersizer 2000 systems are all employed within the university’s multi-disciplinary lab. The instruments serve a wide variety of research groups working in areas as diverse as silica coating formulation through to tissue regeneration, demonstrating the value that Malvern’s robust technology brings throughout the scientific arena. “Our lab is part of The School of Engineering and...

Dr Alan Rawle, Applications Manager for Malvern Instruments, will give a plenary lecture at Particulate Systems Analysis (PSA) 2014, organized by the Royal Society of Chemistry’s Particle Characterization Group.

The event takes place from 15-17 September 2014 at the Manchester Conference Centre, Manchester UK, and this year incorporates the UK Particle Technology Forum and Fine Bubble Symposium. The title of Dr Rawle’s lecture is ‘TLAs and the 4Qs in relation to elucidation of particle sizing issues’ where, of course, TLA stands for ‘Three-Letter Acronyms’. “The prime objective is entertainment with an educational experience as a sideline,” said Alan Rawle. “I’ve used TLAs over the years as an...

Researchers at The School of Freshwater Science, University of Wisconsin-Milwaukee, USA, are using NanoSight Nanoparticle Tracking Analysis (NTA) from Malvern Instruments to investigate the effects of nanoparticle contaminants on freshwater organisms.

The work, which is at the forefront of nanotoxicity testing, has focused on using the unique size, concentration and visualization capabilities provided by NTA to monitor how specific changes in nanoparticle surface chemistry influence the impact of the particles on molecular species in environmental media. NTA is used as part of an ensemble of analytical techniques that includes Dynamic Light Scattering (DLS) with the...

Malvern Instruments Ltd has announced that it has completed the acquisition of MicroCal from GE Healthcare Life Sciences and has also purchased the Archimedes particle characterization system from Affinity Biosensors LLC 

The agreement to purchase GE Healthcare Life Sciences’ MicroCal business was announced on 4 June 2014 by Malvern’s parent company Spectris plc, and completion follows regulatory approval of the transaction. MicroCal microcalorimeters are now part of the Malvern Instruments portfolio and are being sold and supported by Malvern Instruments with immediate effect. Users of MicroCal systems have been notified directly of any changes and full details of the product range are available on the Malvern website....

The new Zetasizer Helix from Malvern Instruments is a powerful tool for early stage biopharmaceutical development that enables the detailed study of mechanisms of protein aggregation.

This new system combines industry-leading Zetasizer dynamic light scattering (DLS) technology, for sizing of proteins and other biomolecules, with Raman spectroscopy. Raman spectroscopy enables monitoring of the changes in secondary and tertiary protein structure. The combination of DLS and Raman spectroscopy allows measurement of protein size and structure from a single small volume sample, providing unique insight into...

A new brochure from Malvern Instruments details the range of detectors available for Gel Permeation/Size Exclusion Chromatography (GPC/SEC).

It also provides scientists with the background required to choose the detector array most appropriate to maximizing information flow and experimental productivity. Available as standalone units, or as part of a fully integrated Viscotek multi-detection GPC/SEC system, Malvern’s GPC/SEC detectors provide highly accurate analysis of polymer and protein macromolecular features, such as molecular weight, and combine to offer advanced insight into molecular structure...

Malvern Instruments has been successful in securing £3 million support from the UK Government’s Regional Growth Fund (RGF) that will lead to the creation of 47 new jobs in the UK over the next five years.

A new whitepaper on the application of Analytical Quality by Design (AQbD) to particle size assessment has been published by Malvern Instruments.

AQbD is an innovative approach to the development and validation of analytical methods that brings the benefits of Quality by Design (QbD) to pharmaceutical analysis. Malvern’s new whitepaper, ‘Beyond SOPs – Exploring the rigor and requirements of Analytical QbD’, introduces the AQbD concept, explains the associated workflow and illustrates how to apply AQbD when developing methods for laser diffraction particle sizing. The whitepaper is freely available for download from the Malvern resource center....

Researchers from the Département Environnement et Agro-biotechnologies at the CRP - Gabriel Lippmann in Luxembourg use Nanoparticle Tracking Analysis for toxicology studies 

The Département Environnement et Agro-biotechnologies (EVA), of the Centre de Recherche Public - Gabriel Lippmann, Luxembourg, employs NanoSight Nanoparticle Tracking Analysis (NTA) method from Malvern Instruments to perform environmental analysis and toxicological testing of nanoparticles...

The new Zetasizer NanoSampler from Malvern Instruments is a versatile, compact, fully automated sample delivery system for the Zetasizer Nano, the most widely used system for nanoparticle and colloid characterization.

Delivering precise and reproducible automated sample loading, and accommodating up to 96 sample vials, the NanoSampler enables unattended operation of the Zetasizer Nano, to maximize analytical productivity. It is especially suitable for laboratories where reproducibility is critical and where multivariate studies are routine. The new NanoSampler will work with all of the sizing systems in the Zetasizer Nano instrument range. This range includes both exceptionally high performance and entry level systems that measure particle and molecular size using dynamic light scattering, covering a size range from less than one nanometer up to several microns....

The Département Environnement et Agro-biotechnologies (EVA), of the Centre de Recherche Public - Gabriel Lippmann, Luxembourg, employs NanoSight Nanoparticle Tracking Analysis (NTA) method from Malvern Instruments to perform environmental analysis and toxicological testing of nanoparticles.

Researchers within the EVA department are using the technique of Nanoparticle Tracking Analysis (NTA) for the characterization of nanoparticles within their toxicological studies. A team led by toxicologist Dr. Arno Gutleb is working closely with colleagues in the Département Science et Analyse des Matériaux (SAM) both to characterize the particles that they produce and to investigate the environmental and toxicological impact of these and other nanomaterials.....

Dr. Alan Rawle, Applications Manager for Malvern Instruments, has been invited to speak as part of the Brian Scarlett Memorial Session at the 7th World Congress for Particle Technology.

Dr Rawle’s presentation will discuss ‘Sampling – another Cinderella of particle size analysis’ and he will highlight the importance of representative sampling for particle size analysis, explaining how  to employ statistical methods to obtain accurate and reproducible results. “Brian Scarlett was one of the most recognized, respected and effective leaders in particle technology and it is a real honor to be contributing to this memorial session,” said Alan Rawle....

Alexander Seifalian is Professor of Nanotechnology and Regenerative Medicine at UCL Centre for Nanotechnology and Regenerative Medicine within the Division of Surgery and Interventional Science at University College London, UK. His research focus is on the development of human organs using nano composite materials and stem cells as well as treatment of cancer using nanoparticles.

With nanoparticles requiring rapid and repeatable measurement, Professor Seifalian selected Malvern’s NanoSight Nanoparticle Tracking Analysis (NTA) system. Previous to this, he had used techniques including scanning electron microscopy (SEM) and atomic force microscopy (AFM) but found that NTA made measuring size easier and more accurate. Professor Seifalian’s paper, "Fumed Silica Nanoparticle Mediated Biomimicry for Optimal Cell-Material Interactions for Artificial Organ Development” published in the Journal of Macromolecular Biosciences...

Malvern Instruments is proud to be a premier sponsor of the inaugural PEGS China meeting.

The PEGS China Protein & Antibody Engineering and Development summit is presented by Cambridge Healthtech Institute and takes place in Shanghai from 1 - 3 April 2014. Malvern is participating in both the conference and the associated exhibition, with Dr Wei Qi, Senior Scientist within Malvern’s Bioscience Development Initiative, presenting a paper on ‘Emerging techniques for therapeutic protein characterization – viscosity, stability and sub-visible particles’....

Following the launch of the new m-VROCi, Viscometer/Rheometer On a Chip, at Pittcon 2014, Malvern Instruments will focus on the unique technology of this system and the considerable benefits it delivers in a webinar on 16 April 2014. The m-VROCi provides safe, accurate viscosity measurement for low viscosity industrial fluids, under conditions that reflect those that apply during end-product use.

New partnership between Malvern Instruments and RheoSense brings m-VROCi to industrial markets

“We are delighted to be working with RheoSense, Inc to bring the benefits of the m-VROCi to industrial customers across the globe,” said Steve Carrington, Product Manager for Malvern Instruments. “The m-VROCi is highly complementary to the existing Malvern rheological portfolio, extending robust, fully enclosed (no solvent loss) flow curve measurement into areas that simply aren’t accessible with alternative rheological instrumentation...

Malvern Instruments will demonstrate NanoSight Nanoparticle Tracking Analysis (NTA) at BioNanoMed 2014

The 5^th International Congress on Nanotechnology, Medicine and Biology, which takes place in Krems, Austria from 26 – 28 March. A specialist from the company will also make a 10-minute presentation as part of the business sessions held alongside the conference. The acquisition of NanoSight in September 2013 has extended Malvern’s range of analytical solutions for characterization at the nanoscale, with NTA ideally complementing the company’s Zetasizer Nano, Archimedes and Viscotek SEC systems...

Dr Wei Qi and Dr Linda Kidder, both senior scientists within Malvern Instruments’ Bioscience Development Initiative, will present work on techniques for protein analysis at the 2014 Biotherapeutics Analytical Summit which takes place in Baltimore MD, USA, from 24-27 March.

The topic of Dr Wei Qi’s poster is ‘Emerging Techniques for Therapeutic Protein Characterization - Viscosity, Stability and Sub-Visible Particles’  while Dr Linda Kidder’s oral presentation on 25 March will discuss ‘Improved Understanding of Association Between Protein Colloidal and Conformation Stability with Combined DLS/Raman’. Dr Kidder will describe how the combination of dynamic light scattering (DLS) and Raman spectroscopy presents a novel approach to protein therapeutics characterization.....

Malvern Instruments shows how complementary technologies solve analytical challenges from biopharm to bulk materials 

Pauline Carnell, Senior Application Scientist at Malvern Instruments, will present a paper at ISEV 2014 discussing ‘The practical use of nanoparticle tracking analysis (NTA) to characterise extracellular vesicles in general and when using fluorescence markers’.

Renowned protein scientist Prof. Dr. John F. Carpenter shows how combining Dynamic Light Scattering with Raman Spectroscopy delivers new insights in protein stability, aggregation and structure

Malvern Instruments welcomes Prof. Dr. John F. Carpenter, from the University of Colorado Center for Pharmaceutical Biotechnology, as a guest presenter contributing to the company’s current series of webinars. Professor Carpenter is a renowned expert in mechanisms for protein degradation and stabilization in pharmaceutical formulations. In his webinar on 18 March 2014 he will discuss how the combination of dynamic light scattering technology with Raman spectroscopy delivers new insights into the measurement and prediction of protein stability, aggregation and high order structure....

Malvern Instruments Ltd (Malvern, UK) has announced an exclusive global distribution agreement with RheoSense, Inc. (San Ramon, CA, USA) to promote, market, sell and support the VROC product range into industrial applications.

The agreement enables Malvern to add the m-VROCi, microfluidic Viscometer/Rheometer On a Chip, to its existing portfolio of rotational and capillary rheometers, extending the company’s offering to industrial customers across the globe. Delivering accurate, robust, fully enclosed viscosity measurement, at high shear rates, the m-VROCi addresses an established need to measure low viscosity fluids under process relevant conditions. The results have proven application for the characterization and enhancement of inkjet inks, coatings, rechargeable batteries, lubricants, chemical and food additives, and drink formulations...

The application of morphologically directed Raman spectroscopy to characterizing the component-specific particulate properties of the active components in a topical pharmaceutical cream is described in an application note from Malvern Instruments.

Malvern Instruments has kicked off another year of its highly popular open-access webinar program and on 21 January the ‘Step into the Light’ webinar offers insight into the use of dynamic light scattering technology to improve the quality of biopharmaceutical data in purity profiles.

This is followed on 23 January by ‘Optimization and characterization of nanomaterials for drug delivery applications. Part 1 – Liposomes’.  ‘Where do I find source material in light scattering?’ is the topic on 28 January, and the first of this year’s laser diffraction masterclass series goes out live on 30 January. Accurately identifying impurities and generating purity profiles presents substantial challenges to biopharmaceutical developers, who require the most sensitive analysis methods available. ‘Step into the Light’ will explore the analytical challenges within biopharmaceutical development

Malvern Instruments brings a new addition to Pittcon in 2014, exhibiting NanoSight Nanoparticle Tracking Analysis (NTA) systems within its growing portfolio of analytical solutions for industry and academia.

Pittcon 2014 is Malvern’s first major exposition in the US since acquiring NanoSight in September 2013, a move which resulted in the addition of NTA to Malvern’s technologies for particle sizing and counting at the nanoscale. NTA systems will be on show alongside the Zetasizer Nano and the new Viscotek SEC-MALS 20 GPC/SEC detector.  Also on the Malvern booth is the Mastersizer 3000 laser diffraction particle size analyzer featuring new software....

Malvern Instruments has posted a new application note demonstrating the use of the company’s Viscotek SEC-MALS 20 multi angle light scattering (MALS) detector for size exclusion chromatography (SEC) in the analysis of monoclonal antibodies.

The application note, ‘Molecular weight measurements of an antibody using Viscotek SEC-MALS 20’, reports experimental data for the analysis of aggregates within monoclonal antibody formulations and can be freely downloaded. Monoclonal antibodies are being targeted for use in a growing range of therapeutic applications. Measuring the molecular weight of the protein, monomer, oligomers and aggregates within the sample and in formulations is an important part of assessing their safety and efficacy as drugs.....

A new application note from Malvern Instruments explores the role of particle size and the importance of particle size measurement in optimizing the formulation of drilling muds used in oil extraction processes.

New customer feedback points up benefits of the Mastersizer 3000

A recent webinar showcasing new software features for the Mastersizer 3000 proved an opportunity for Malvern Instruments’ customers to reflect on how, two years on from its launch, this groundbreaking instrument is delivering valuable benefits. Customers cite its small footprint, truly intuitive and intelligent software interface, as well as the ease of transferring from an existing system to the new instrument, as the most popular features. The new software further enhances these elements of performance and was demonstrated during the webinar...

The launch of Malvern Instruments’ Viscotek SEC-MALS 20 chromatography detector has triggered record downloads of one of the supporting white papers ‘Static light scattering technologies for GPC/SEC explained’, underlining the enthusiasm amongst users for straightforward information on GPC/SEC analysis.

The recent addition of Viscotek SEC-MALS 20 to Malvern’s range of detectors puts the company in the unique position of being the sole provider of every commercially available light scattering technology for GPC/SEC. Customers can therefore be assured of a truly unbiased choice of detector solutions. The popular white paper is just one of a suite of educational information and application notes provided by Malvern’s specialist team to help users select the right detector for their application...

Malvern Instruments has recently released an article detailing the use of laser diffraction particle size analysis  for powder metallurgy applications.

Entitled ‘Using laser diffraction to measure particle size distributions’, the article presents new data on how laboratory and on-line laser diffraction provide the comprehensive particle size and size distribution data required to support metal powder product and manufacturing process development. Powder metallurgy - the production of a solid object from the sintering of a fine metal powder - is a versatile and precise method for creating a wide range of metal components.....

In a move that reflects continued sales growth in Mexico, Malvern Instruments has opened a new office in Mexico City.

Operational since August 2013, the Mexico office provides both pre- and after- sales support to a growing customer base. It is also the venue for an increasing number of advanced training courses and seminars, and is part of Malvern’s operational expansion in Mexico and throughout Latin America as a whole. The opening of the office in Mexico comes just a year after the establishment of a sales and applications laboratory in Sao Paolo, Brazil...

A refreshingly modern and inviting operating environment led independent, commercial materials testing laboratory NSL Analytical Services (Cleveland, US), straight to the Mastersizer 3000 from Malvern Instruments when it came to choosing a laser diffraction particle size analyzer to extend testing capabilities.

“The software really is the shining star of this product,” said Brian Bacher, Technical Specialist at NSL. “It makes the Mastersizer 3000 feel radically different from other systems on the market and a really great instrument to use. I especially like the live trends which make it so quick and easy to compare data sets,” he continued. NSL provides physical material testing to multiple verticals including the aerospace, ceramics and powder metallurgy industries...

Malvern Instruments is marking the second anniversary of the market leading Mastersizer 3000 laser diffraction particle sizing system with the introduction of a host of innovative software updates and an extension to the Mastersizer family, the Mastersizer 3000E.

A global leader for particle sizing, Malvern’s Mastersizer range has become synonymous with laser diffraction. The Mastersizer 3000 delivers unique performance and productivity benefits, wrapped in a stylish, compact and practical instrument design. New software features, developed in response to customer feedback, now make it easier than ever to obtain accurate particle size information....

Malvern Instruments has introduced two new models to its Kinexus line of rotational rheometers.

The new Kinexus pro+ and Kinexus ultra+ incorporate enhancements to Malvern’s unique proprietary air bearing technology, the performance defining technology that sits at the heart of the rotational rheometer. These enhancements add to the capabilities of Malvern’s rotational rheometers for R&D by extending the range and robustness of test conditions that can be applied during rheological characterization. Full details of the new Kinexus models are on the Malvern website where visitors can also download a brochure describing the complete Kinexus range...

Team also publishes paper examining ability to distinguish between protein aggregates and oil droplets in biopharmaceutical formulations

Coriolis Pharma (Martinsried, Germany) has become the first pharmaceutical contract research organization in the world to routinely use Archimedes, a new analytical instrument supplied by Malvern Instruments. Coriolis Pharma specializes in formulation development for biopharmaceuticals such as proteins, peptides and vaccines and offers a wide variety of services to support product development...

Malvern Instruments is to showcase the company’s range of analytical solutions for pharmaceutical materials characterization at the 2013 AAPS Annual Meeting & Exposition, from 11-14 November in San Antonio TX, USA.

Visitors can tap into the expertise of Malvern’s technical and applications specialists and find out how the company’s range of technologies and instrumentation provides valuable information across the entire pharmaceutical development spectrum, from pre-formulation through to quality control. New systems on show will include the Viscotek SEC-MALS 20 multi-angle light scattering detector for GPC/SEC. The new Viscotek SEC-MALS 20 has more detectors than any other commercially available multi angle light scattering system

Malvern Instruments Ltd (Malvern, UK), a leading global provider of instrumentation and expertise for materials and biophysical characterization, has acquired nanoparticle characterization company NanoSight Ltd (Amesbury, UK). The acquisition was completed on Friday 27 September 2013.

Malvern Instruments has introduced new software for the Morphologi G3 particle characterization system, extending the instrument’s capabilities to include the detailed measurement of fibers.

The Morphologi G3 measures the size and shape of particles by image analysis and the new software function delivers accurate measurement of fiber-specific parameters, including fiber total length, fiber width, fiber straightness and fiber elongation. Many manufactured materials and intermediates are fibrous in nature, including insulation products, reinforcing materials, textiles and of course carbon fiber. Each has its own unique properties and a detailed understanding of the individual properties is essential from R&D through to manufacturing and quality control...

A set of application notes from Malvern Instruments demonstrates the sample integrity, flexibility and lack of cross contamination during automated, rapid screening of protein samples using the Zetasizer Auto Plate Sampler (APS) dynamic light scattering (DLS) system.

Enabling automated measurements of multiple samples, the Zetasizer APS delivers the same high sensitivity, high specification DLS measurements as other systems in Malvern’s well-known Zetasizer series, making it ideal for protein applications. Easy data interpretation, using custom-designed results criteria, is supported by a colour-coded data quality display. Zetasizer APS allows the production of large amounts of high quality DLS data with no user intervention to maximize productivity in busy protein laboratories. The data display capability enables the operator to easily retrieve results of interest, without having to manually scan through all measurements...

Team also publishes paper examining ability to distinguish between protein aggregates and oil droplets in biopharmaceutical formulations

Coriolis Pharma (Martinsried, Germany) has become the first pharmaceutical contract research organization in the world to routinely use Archimedes, a new analytical instrument supplied by Malvern Instruments. Coriolis Pharma specializes in formulation development for biopharmaceuticals such as proteins, peptides and vaccines and offers a wide variety of services to support product development....

Long time Malvern Instruments team member Dr Alan Rawle was recently admitted as a Fellow of the Royal Society of Chemistry (FRSC).

Dr Rawle has worked extensively with laser diffraction and other particle characterization techniques for more than two decades and the RSC fellowship recognizes his services to chemistry and continued contribution to analytical science.Based primarily in the US and serving as Malvern’s Divisional Applications Manager, Dr Rawle is currently on a six-month secondment to Malvern’s global headquarters in the UK...

Dr E Neil Lewis, Chief Technology Officer at Malvern Instruments and Head of the company’s Bioscience Development Initiative, will speak at the International BioAnalytical Congress taking place in Berlin (Germany) on 11 and 12 September 2013.

A presentation by technology specialist Dr Richard Tweedie, given as part of the recent UK Formulation Showcase at NanoFormulation 2013 (18-21 June 2013, University of Manchester, UK), illustrated the mutual benefits of an ‘open innovation’ approach to product development.

His talk focused on the ‘open innovation’ pathway adopted by Malvern Instruments in collaboration with The University of Leeds in the UK to develop the Aero S, one of the key sample dispersion systems for Malvern’s Mastersizer 3000 laser diffraction particle size analyzer. The Aero S dry powder disperser was launched alongside the Mastersizer 3000 in September 2011 and immediately delivered new capabilities to laser diffraction users, extending dry powder dispersion to even the most fragile materials...

Malvern Instruments is showcasing new analytical tools for biopharmaceutical applications on its exhibition booth at The Bioprocessing Summit in Boston

In July the company launched two new systems, the Viscotek SEC-MALS 20 and the Viscosizer 200, for the characterization of biological materials. These join Malvern’s rapidly growing range of analytical instruments, which also includes the Zetasizer Nano ZSP, for use in pre-formulation and formulation studies and for the wider characterization of proteins and other macromolecules.....

Malvern Instruments has kicked off a brand new series of Masterclass webinars available both as live events and subsequently as recorded presentations.

Based on the company’s established Masterclass concept, the ‘Masterclass on Suspension Properties’ series guides participants on how to use rheology in combination with other analytical techniques in order to formulate suspensions to meet specific performance targets. The information is delivered in a very straightforward style, making the subject easily accessible and comprehensible to the broadest of audiences...

The launch of the Viscotek SEC-MALS 20 brings new standards of performance and greater choice in gel permeation/size exclusion chromatography (GPC/SEC) and extends the Malvern Instruments family of light scattering detectors for measuring the absolute molecular weight of proteins, macromolecules and polymers.

Malvern’s Viscotek range now includes cost-effective options with unsurpassed performance for every type of light scattering detection – low angle, right angle and multi angle – allowing Malvern to answer every GPC/SEC challenge with the most appropriate technology. With this extension to its detectors range, Malvern becomes the only vendor to offer all light scattering options....

A series of  new application notes posted on the Malvern Instruments website describes the quick and easy measurement of surface zeta potential using the zeta potential planar cell for the Zetasizer Nano particle characterization system.

Widely used as an indicator of the stability of particle suspensions and colloidal samples, surface zeta potential is traditionally measured using the specialist technique of streaming potential. Malvern’s Surface Zeta Potential Cell eliminates the need for a dedicated solution, allowing users to measure the zeta potential of surfaces in an aqueous medium on a standard instrument. The application note ‘Determination of the zeta potential of the surface of PTFE’, and others relating to different aspects of the measurement, can now be downloaded from Malvern’s online knowledge center...

Malvern Instruments has published ‘Static Light Scattering Technologies For GPC/SEC Explained’, a valuable guide for anyone assessing the value of a light scattering detector for gel permeation/size exclusion chromatography (GPC/SEC).

A series of  new application notes posted on the Malvern Instruments website describes the quick and easy measurement of surface zeta potential using the zeta potential planar cell for the Zetasizer Nano particle characterization system.

Cemtec (Enns, Austria) a specialist provider of grinding technologies for the mining, mineral and cement industries, is using Insitec real-time particle sizing technology from Malvern Instruments to provide fully integrated, automated milling solutions that deliver high efficiency at competitive cost.

An exchange of equipment, between the two companies, has led to the installation of an Insitec system for the control of dry milling at Cemtec’s extensive pilot plant facility and now customers of both companies can see for themselves how real-time particle sizing can transform process performance. “Increasingly customers are looking for us to provide turnkey, often automated, milling circuits, rather than a stand alone mill,” said Mr Plochberger, Head of R&D and Process Technology at Cemtec...

In a new paper published in Polymers & Polymer Composites (Vol 21, No 1, 2013), researchers at Kingston University in the UK report the results of continuing work to examine the effects of gamma irradiation on intraocular lenses (IOLs) used in cataract surgery. Triple detection gel permeation chromatography (GPC) using the Viscotek TDAmax system from Malvern Instruments was a key analytical tool in this work.

For those working at the forefront of polymer development, adding a Malvern Viscotek viscometer detector into gel permeation/size exclusion chromatography (GPC/SEC) set ups can help deliver the enhanced information need to achieve challenging performance specifications. 

Studies with evolving commercial polymers, such as polymethylmethacrylate (PMMA) and polylactic acid (PLA), show how the structural information revealed by measuring viscosity parameters enables researchers to intelligently modify polymer chain length and branching to meet precise goals. Malvern Viscotek viscometers can be supplied as part of an integrated triple detector Viscotek GPC/SEC system or as an addition to any existing separation system....

US Court of Appeals characterizes Wyatt Technology Corporation Lanham Act claims as “groundless, unreasonable, vexatious or pursued in bad faith”

Malvern Instruments Inc. has scored a decisive win in the final round of a long-running court battle waged by Wyatt Technology Corporation regarding the sale of Malvern’s Zetasizer Nano range in the US. Wyatt had alleged copyright infringement of software and other materials, false advertising and theft of trade secrets, and sought damages from Malvern in excess of $25 million (USD). However, Wyatt has ended up having to reimburse Malvern more than $2 million (USD) in respect of attorneys’ fees and costs.

Malvern Instruments, a leader in the field of pharmaceutical material characterization, has announced a global agreement with Proveris Scientific Corporation, a company with complementary technology for orally inhaled and nasal drug product (OINDP) testing, to provide a complete solution for nasal spray characterization....

Materials and biophysical characterization company Malvern Instruments Ltd and NETZSCH Grinding & Dispersing a worldwide manufacturer of industrial wet and dry grinding, mixing, dispersing and kneading equipment, have entered into a cooperative marketing agreement.

Both organizations serve a broad range of market sectors from pharmaceuticals, ceramics, nano-technology applications, food and surface coatings through to mining metals and minerals. The global agreement, initially in place for three years, will harness the strength of each company’s world-leading brands and unique expertise in materials processing and materials characterization. Under the terms of the agreement NETZSCH will standardize on Malvern’s particle sizing and characterization equipment, primarily the Mastersizer 3000 laser diffraction particle size analyzer...

Malvern Instruments, a company keen to share its  new technology for microrheology, is sponsoring the 8th Annual European Rheology Conference which takes place  in Leuven, Belgium, 2nd to 5th April 2013

Expert rheologists from Malvern will be in attendance throughout the event, and on display will be the Kinexus, a high performance rotational rheometer that enables advanced shear and vertical testing, and the Zetasizer Nano ZSP, a premium light scattering system with microrheology capability.The conference brings together leading rheologists from around the world for four days of lectures and seminars. Microrheology, a relatively new technique, is sure to be a popular topic for discussion...

Researchers at the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany,  have incorporated a multi-detector array size exclusion chromatography (SEC) system from Malvern Instruments (Viscotek TDA –Triple Detector Array) at the laboratory’s powerful small angle X-ray scattering (SAXS) beamline to improve the productivity and quality of detailed protein characterization work

Use of the Viscotek TDA triple detector array system prior to analysis provides complementary biophysical data and simultaneously purifies samples for measurement. This results in more information and better quality data from each experiment. This innovative set-up is not only limited to the institute itself, but  is widely accessible to structural biology researchers via BioStructX, a European Commission initiative that creates a single gateway to Europe’s leading synchrotron facilities...

Leading technologists from Malvern Instruments, the materials characterization experts, will be presenting at Powtech

Malvern Instruments’ new series of web-based Imaging Masterclasses kicks off on 26 February 2013 with an introduction to imaging for particle characterization

The series will then continue through the year and will cover a broad range of imaging topics. Alongside this will run the laser diffraction Masterclass series which will discuss subjects including wet method development, dry method development, optical property selection and specification setting...

With the introduction of the Morphologi G3-ID system last year, Malvern Instruments is providing researchers with the ability to apply morphologically directed Raman spectroscopy to a range of different sample types

Following the recent launch of the top-of-the-range Zetasizer Nano ZSP system, Malvern Instruments has published a new brochure that helps potential purchasers select the right Zetasizer Nano dynamic light scattering system for their specific colloid, nanoparticle or macromolecule application

In a session devoted to protein aggregation and emerging analytical tools at this year’s PepTalk conference, Dr E. Neil Lewis, Chief Technology Officer for Malvern Instruments, will discuss ‘Recent advances in the integrated measurements of size, high order structure and formulation viscosity of biopharmaceutical formulations’

A new application note on the Malvern Instruments website describes the use of morphologically directed Raman microscopy in assessing the bioequivalence of a generic and innovator drug with a dual active pharmaceutical ingredient (API)

The work was carried out using the Morphologi G3-ID, which combines automated image analysis with Raman spectroscopy. The Morphologi G3-ID enables the determination of component-specific particle size distributions, which in this study were important because of  the effects of particle size on tablet disintegration and subsequent bioavailability. ‘Generic versus Innovator: an In-Vitro Bioequivalence Study with the G3-ID’ is freely available as a download from the Malvern website....

New application note discusses particle sizing, specific surface area and predicting attrition rate in fluidized beds

Dr Kikuo Okuyama of the Department of Chemical Engineering at the Graduate School of Engineering, Hiroshima University in Japan, was the first customer to take delivery of a Zetasizer Nano ZSP, the new top-of-the-range dynamic light scattering system from Malvern Instruments

In Dr Okuyama’s work the objective is to find alternative materials for rare earths and to develop rare earth-free functional materials. This involves research into the composition and structure of functional fine particles and will use the Zetasizer Nano ZSP in the evaluation of nano particle size, dispersion and surface chemistry...

Apply both dynamic and static light scattering for size and molecular weight measurement

One of the most significant applications for Malvern Instruments’ new Zetasizer Nano ZSP dynamic light scattering system is the highly sensitive measurement of the zeta potential, or electrophoretic mobility, of proteins

Malvern Instruments will showcase the new Morphologi G3-ID particle characterization system at Drug Delivery to the Lungs 23, which takes place from 5 – 7 Dec 2012 in Edinburgh, Scotland

Materials characterization company Malvern Instruments Ltd. (Malvern, UK) has signed an exclusive distribution agreement with Affinity Biosensors LLC (Santa Barbara, CA, USA) which will extend the range of solutions that Malvern offers to the biopharmaceutical sector. The distribution agreement covers all geographies outside the USA and Canada

In a recently published article, researchers from Novozymes Biopharma (Nottingham, UK) and Malvern Instruments (Malvern, UK) describe collaborative work using light scattering techniques to demonstrate the short- and long-term stability of the novel recombinant human albumins Albucult® and Recombumin®

These rAlbumins have been developed and optimized to deliver a safe, stable and regulatory-compliant product for therapeutic formulations. The teams applied the resolving and detection capabilities of size exclusion chromatography light scattering (SEC-LS) and dynamic light scattering (DLS) offered by Malvern systems to monitor the stability of these Novozymes products. The article ‘Tools for evaluating the stability of human recombinant albumins used in human therapeutics’ can be accessed at...

Malvern Instruments, a leading provider of scientific instruments for materials characterization, kicked off a scientific discovery programme with a presentation to Malvern St James Girls’ School in Worcestershire to encourage students into a career in science or engineering

New Zetasizer Nano ZSP offers emerging rheology technique for weakly structured fluids

With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.

Following the completion of a highly successful early access program, Malvern Instruments has launched the Morphologi G3-ID particle characterization system to the global market

In a new presentation from Malvern Instruments entitled ‘Moving laser diffraction from the laboratory into the production process’, Product Group Manager Dr. Paul Kippax discusses the benefits and challenges of taking laboratory-based particle sizing out into the production process

On 12 September 2012 Malvern Instruments conducted the global launch of an exciting addition to its Zetasizer family, bringing unique protein measurement and novel microrheology capabilities to this established and market-leading range of dynamic light scattering (DLS) systems

A novel gel permeation chromatography (GPC) method for characterizing Nylon, developed by researchers at Malvern Instruments, significantly reduces the cost of analysis while simultaneously improving safety, when compared with conventional techniques

"The Zetasizer Nano ZS is an integral piece of equipment in our polymer characterization laboratory," said Daniel Krasznai, Department of Chemical Engineering, Queen's University, Kingston, Canada. "The most important features that the Zetasizer Nano ZS offers are rapidity, reproducibility, and a user-friendly interface."

New experimental data published by Malvern Instruments illustrate the real-world capability and flexibility of the Mastersizer 3000 laser diffraction system for the particle size measurement of dry powders

Join one of Malvern Instruments UK seminars in April and learn how to develop better products by understanding the size, shape, chemistry and rheological behaviour of materials.  These one-day events, which combine expert presentations with hands-on sessions, are taking place in Newport (17 April), Ascot (18 April), Stirling (25 April) and Bradford (26 April)...