Organic solvents that are commonly used in various chemical processes have significant financial costs and can be environmentally damaging. Therefore, a key goal for both industrial and academic labs is to reduce their use in favour of green solvent alternatives. Here Paul Vanden Branden, director and product manager at laboratory equipment supplier SciMed, discusses the potential of supercritical CO2 for replacing environmentally damaging solvents, such as hexane, in separations and extractions...
INTEGRA Biosciences’ pipetting platforms are being used to streamline the liquid handling steps involved in antimicrobial susceptibility testing (AST), contributing to the early detection of antimicrobial resistance (AMR) and helping to direct patients onto the appropriate care pathway as soon as possible. AMR has become one of the largest threats currently facing public health, with morbidity and mortality rates rising dramatically across the world...
Automata, a leading automation company powering life sciences labs, has announced it is partnering with the Advanced Sequencing Facility (ASF) at The Francis Crick Institute, a world-leading laboratory at the forefront of genomics, to unlock the power of open, integrated automation for genomics sample preparation. Integrated automation will support the Crick’s cutting-edge advanced genomics laboratory with greater walkaway time, R&D flexibility and data quality than ever before...
Benchling – the cloud R&D powering the biotechnology industry – launches a new whitepaper in partnership with AstraZeneca, exploring how AstraZeneca has become the first company to recycle critical DNA constructs at scale, reducing the cost of creating DNA constructs by 80-90%. The whitepaper explores how AstraZeneca’s combined team of computational and molecular biologists, along with Benchling, have created the FRAGLER (FRAGment recycLER), a novel solution for the whole DNA synthesis industry..
Computer modelling of our very first cells following conception has provided new insights that could lead to new ways of tackling disease through personalised medicine and cell therapy. A scientist at the University of Leicester has created the first computer model that captures the gene networks involved in human gastrulation, the point at which our cells start to develop our tissues and organs, once dubbed ‘the most important time in your life’...
Wheat containing exotic DNA from wild relatives benefits from up to 50 per cent higher yields in hot weather compared with crops lacking these genes. Following a year when temperature records have been smashed, research from the Earlham Institute in Norwich, in collaboration with the International Maize and Wheat Improvement Centre (CIMMYT), offers much-needed hope for improving crop resilience and food security in the face of climate change...
Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, has announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases. Overseen by structural biology experts Professor Helen Walden, UoG, and Dr Mehmet Gundogdu, Principal Scientist at Ubiquigent...
Top 5 Questions to fnd the Perfect Preparative HPLC System for your Purification needs. There are many variables to consider when configuring an HPLC system. To help, here are the top five questions you need to answer. Sample Injection, do you need manual or automated sample injection?. Pumping System, what size of column do you need? Detection, what type of detector do you require? Top tips from Gilson...
Eppendorf and the journal Science are now accepting applications for the 2023 Eppendorf & Science Prize for Neurobiology. This annual international research prize of US$25,000 is awarded to young scientists for their outstanding contributions to neurobiological research based on methods of molecular and cell biology. Researchers who are not older than 35 years are invited to apply by June 15, 2023...
As part of a global, multiyear agreement, Thermo Fisher Scientific has announced it is working with AstraZeneca to develop a solid tissue and blood-based companion diagnostic (CDx) test for Tagrisso (osimertinib). The CDx will help identify patients with non-small cell lung cancer (NSCLC) who may be eligible for treatment with Tagrisso by identifying tumors that exhibit epidermal growth factor receptor (EGFR) alterations including exon 21 L858R mutations, exon 19 deletions or T790M mutations...
Scientists at Microsynth – a leading European company in nucleic acid synthesis, analysis and sequencing – are taking advantage of the remarkable liquid handling capabilities of INTEGRA’s MINI 96 and VIAFLO 96 handheld electronic pipettes in workflows ranging from nucleic acid isolation to sequencing and different types of PCR. Dr Sergey Yakushev, Head of Genetic Analysis at Microsynth, explained...
Novel method of image analysis reveals how cancer cells manipulate their size to resist treatment. Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered. Scientists at The Institute of Cancer Research, London, combined biochemical profiling technologies with mathematical analyses to reveal how genetic changes lead to differences in the size of cancer cells – and how these changes could be exploited by new treatments...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2023 LIMS Webcast series on Wednesday, February 15, with See How LIMS is Making a Splash in the Water/Wastewater Industry. This webcast will provide an update on some of the leading challenges water, wastewater, and environmental laboratories are facing today and focus on the ways in which some of the latest advances in laboratory automation and LIMS are addressing these challenges...
Chemists from the Chianese Group at Colgate University (NY, USA) have shared kinetic data obtained using the Asynt Multicell 10-position high pressure laboratory reactor in their recent paper, “The Key Role of the Latent N0H Group in Milstein’s Catalyst for Ester Hydrogenation”. Their characterisation of the mechanisms of Milstein’s catalysts has enabled greater understanding of the reactivity of these catalysts in ester hydrogenation...
New Virtual Powder Flow Course happening in February 2023 focusing on the properties of powders! Understanding the flow of powders is essential in many industrial applications. Anyone working with powdered materials has once experienced processability problems like a lack of flowability, heavy sticking on pipes and machine surfaces, or variability in dosage among many other examples...
In this Virtual Powder Flow Course, Granutools explore the properties of powders at different scales, from the interactions between the particles at the micro scale to the consequence on the powder processability. Then, you will learn how this new knowledge can be used to better understand the processability of powders through detailed case studies...
PhoreMost Ltd., the UK-based biopharmaceutical company dedicated to ‘Drugging the Undruggable®’ disease targets, and ThinkCyte K.K, a biotechnology company pioneering novel cell analysis and sorting instruments, has announced a strategic research partnership aimed at advancing modern phenotypic drug screening using artificial intelligence (AI)...
Agilent Technologies Inc. has announce that the U.S. Food and Drug Administration (FDA) has approved Agilent Resolution ctDx FIRST as a companion diagnostic (CDx) to identify advanced non-small cell lung cancer (NSCLC) patients with KRAS G12C mutations who may benefit from treatment with KRAZATITM (adagrasib). This is the first liquid biopsy NGS assay approved by the FDA as a CDx for the newly approved KRAZATI in advanced NSCLC and was developed in collaboration with Mirati Therapeutics...
Aptamer Group plc, the developer of novel Optimer® binders to enable innovation in the life sciences industry, announces a selection of new contract wins where Optimer technology is being explored by partners to offer new strategies for therapeutics and potentially offer improved assay sensitivity and selectivity over antibodies. Optimer binders are oligonucleotide-based affinity ligands generated through the in vitro Optimer platform, which can be used as antibody alternatives...
AMSBIO reports how the Faculty of Biological Sciences at the University of Leeds (UK) is using their specialty reagents for the production, visualization, and analysis of glycans and to investigate their interactions which are instrumental to the advance of glycobiology. Glycobiology is vital for many biological processes — from fertilization to inflammation — helping unlock information about interactions between carbohydrates and proteins...
Whole-genome sequencing of 35,000 de-identified, diverse genomic DNA samples will begin this month. Illumina Inc., a global leader in DNA sequencing and array-based technologies, and Nashville Biosciences LLC, a wholly owned subsidiary of Vanderbilt University Medical Center (VUMC), have announced an agreement with Amgen, a global biopharmaceutical company, to whole-genome sequence approximately 35,000 DNA samples...
The UK’s largest distributor of scientific instrumentation, SciMed, has released a new whitepaper that shares advice with the laboratory industry on ways it can become more sustainable without increasing costs or harming experimental efficiency. These include reducing the use of harmful solvents in procedures such as separations and extractions and using new technology that reduces utilities consumption in lab environments...
Organic solvents that are commonly used in various chemical processes have significant financial costs and can be environmentally damaging. Therefore, a key goal for both industrial and academic labs is to reduce their use in favour of green solvent alternatives. Here Paul Vanden Branden, director and product manager at laboratory equipment supplier SciMed, discusses the potential of supercritical CO2 for replacing environmentally damaging solvents, such as hexane, in separations and extractions...
INTEGRA Biosciences’ pipetting platforms are being used to streamline the liquid handling steps involved in antimicrobial susceptibility testing (AST), contributing to the early detection of antimicrobial resistance (AMR) and helping to direct patients onto the appropriate care pathway as soon as possible. AMR has become one of the largest threats currently facing public health, with morbidity and mortality rates rising dramatically across the world...
Automata, a leading automation company powering life sciences labs, has announced it is partnering with the Advanced Sequencing Facility (ASF) at The Francis Crick Institute, a world-leading laboratory at the forefront of genomics, to unlock the power of open, integrated automation for genomics sample preparation. Integrated automation will support the Crick’s cutting-edge advanced genomics laboratory with greater walkaway time, R&D flexibility and data quality than ever before...
Benchling – the cloud R&D powering the biotechnology industry – launches a new whitepaper in partnership with AstraZeneca, exploring how AstraZeneca has become the first company to recycle critical DNA constructs at scale, reducing the cost of creating DNA constructs by 80-90%. The whitepaper explores how AstraZeneca’s combined team of computational and molecular biologists, along with Benchling, have created the FRAGLER (FRAGment recycLER), a novel solution for the whole DNA synthesis industry..
Computer modelling of our very first cells following conception has provided new insights that could lead to new ways of tackling disease through personalised medicine and cell therapy. A scientist at the University of Leicester has created the first computer model that captures the gene networks involved in human gastrulation, the point at which our cells start to develop our tissues and organs, once dubbed ‘the most important time in your life’...
Wheat containing exotic DNA from wild relatives benefits from up to 50 per cent higher yields in hot weather compared with crops lacking these genes. Following a year when temperature records have been smashed, research from the Earlham Institute in Norwich, in collaboration with the International Maize and Wheat Improvement Centre (CIMMYT), offers much-needed hope for improving crop resilience and food security in the face of climate change...
Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, has announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases. Overseen by structural biology experts Professor Helen Walden, UoG, and Dr Mehmet Gundogdu, Principal Scientist at Ubiquigent...
Top 5 Questions to fnd the Perfect Preparative HPLC System for your Purification needs. There are many variables to consider when configuring an HPLC system. To help, here are the top five questions you need to answer. Sample Injection, do you need manual or automated sample injection?. Pumping System, what size of column do you need? Detection, what type of detector do you require? Top tips from Gilson...
Eppendorf and the journal Science are now accepting applications for the 2023 Eppendorf & Science Prize for Neurobiology. This annual international research prize of US$25,000 is awarded to young scientists for their outstanding contributions to neurobiological research based on methods of molecular and cell biology. Researchers who are not older than 35 years are invited to apply by June 15, 2023...
As part of a global, multiyear agreement, Thermo Fisher Scientific has announced it is working with AstraZeneca to develop a solid tissue and blood-based companion diagnostic (CDx) test for Tagrisso (osimertinib). The CDx will help identify patients with non-small cell lung cancer (NSCLC) who may be eligible for treatment with Tagrisso by identifying tumors that exhibit epidermal growth factor receptor (EGFR) alterations including exon 21 L858R mutations, exon 19 deletions or T790M mutations...
Scientists at Microsynth – a leading European company in nucleic acid synthesis, analysis and sequencing – are taking advantage of the remarkable liquid handling capabilities of INTEGRA’s MINI 96 and VIAFLO 96 handheld electronic pipettes in workflows ranging from nucleic acid isolation to sequencing and different types of PCR. Dr Sergey Yakushev, Head of Genetic Analysis at Microsynth, explained...
Novel method of image analysis reveals how cancer cells manipulate their size to resist treatment. Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered. Scientists at The Institute of Cancer Research, London, combined biochemical profiling technologies with mathematical analyses to reveal how genetic changes lead to differences in the size of cancer cells – and how these changes could be exploited by new treatments...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2023 LIMS Webcast series on Wednesday, February 15, with See How LIMS is Making a Splash in the Water/Wastewater Industry. This webcast will provide an update on some of the leading challenges water, wastewater, and environmental laboratories are facing today and focus on the ways in which some of the latest advances in laboratory automation and LIMS are addressing these challenges...
Chemists from the Chianese Group at Colgate University (NY, USA) have shared kinetic data obtained using the Asynt Multicell 10-position high pressure laboratory reactor in their recent paper, “The Key Role of the Latent N0H Group in Milstein’s Catalyst for Ester Hydrogenation”. Their characterisation of the mechanisms of Milstein’s catalysts has enabled greater understanding of the reactivity of these catalysts in ester hydrogenation...
New Virtual Powder Flow Course happening in February 2023 focusing on the properties of powders! Understanding the flow of powders is essential in many industrial applications. Anyone working with powdered materials has once experienced processability problems like a lack of flowability, heavy sticking on pipes and machine surfaces, or variability in dosage among many other examples...
In this Virtual Powder Flow Course, Granutools explore the properties of powders at different scales, from the interactions between the particles at the micro scale to the consequence on the powder processability. Then, you will learn how this new knowledge can be used to better understand the processability of powders through detailed case studies...
PhoreMost Ltd., the UK-based biopharmaceutical company dedicated to ‘Drugging the Undruggable®’ disease targets, and ThinkCyte K.K, a biotechnology company pioneering novel cell analysis and sorting instruments, has announced a strategic research partnership aimed at advancing modern phenotypic drug screening using artificial intelligence (AI)...
Agilent Technologies Inc. has announce that the U.S. Food and Drug Administration (FDA) has approved Agilent Resolution ctDx FIRST as a companion diagnostic (CDx) to identify advanced non-small cell lung cancer (NSCLC) patients with KRAS G12C mutations who may benefit from treatment with KRAZATITM (adagrasib). This is the first liquid biopsy NGS assay approved by the FDA as a CDx for the newly approved KRAZATI in advanced NSCLC and was developed in collaboration with Mirati Therapeutics...
Aptamer Group plc, the developer of novel Optimer® binders to enable innovation in the life sciences industry, announces a selection of new contract wins where Optimer technology is being explored by partners to offer new strategies for therapeutics and potentially offer improved assay sensitivity and selectivity over antibodies. Optimer binders are oligonucleotide-based affinity ligands generated through the in vitro Optimer platform, which can be used as antibody alternatives...
AMSBIO reports how the Faculty of Biological Sciences at the University of Leeds (UK) is using their specialty reagents for the production, visualization, and analysis of glycans and to investigate their interactions which are instrumental to the advance of glycobiology. Glycobiology is vital for many biological processes — from fertilization to inflammation — helping unlock information about interactions between carbohydrates and proteins...
Whole-genome sequencing of 35,000 de-identified, diverse genomic DNA samples will begin this month. Illumina Inc., a global leader in DNA sequencing and array-based technologies, and Nashville Biosciences LLC, a wholly owned subsidiary of Vanderbilt University Medical Center (VUMC), have announced an agreement with Amgen, a global biopharmaceutical company, to whole-genome sequence approximately 35,000 DNA samples...
The UK’s largest distributor of scientific instrumentation, SciMed, has released a new whitepaper that shares advice with the laboratory industry on ways it can become more sustainable without increasing costs or harming experimental efficiency. These include reducing the use of harmful solvents in procedures such as separations and extractions and using new technology that reduces utilities consumption in lab environments...