Biomolecule Purifications and Analytics Using CIM Monoliths
Hichrom Limited are pleased to announce that they have been appointed as UK distributor for BIA Separations, the leading developer and manufacturer of CIM® (Convective Interaction Media) monolithic chromatographic columns for production, purification and analytics of large biomolecules. BIA Separations is headquartered in Austria, with sales offices in the US and China. Their mission is to develop and produce CIM monolithic columns of highest quality and provide superior research and method development services for the purification and analytics of biomolecules....
The ground-breaking sensitivity of Malvern Instruments’ new OMNISEC gel permeation chromatography/size exclusion chromatography system generated significant excitement from scientists meeting at the Seventh International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-7), when the system made a well-received debut late in January.
“Delegates were particularly enthusiastic about OMNISEC’s sensitivity,” said Paul Clarke, Industrial Portfolio Manager at Malvern Instruments. “Announcing ‘the most sensitive light scattering detector on the market’ is one thing but seeing what that actually means in practice is another. Demonstrations of the system measuring the molecular weight (MW) of a 100,000 Da Polystyrene standard with just a 100 ng of sample made a big impression and...
EcoPure brand caps for chromatography vials offer an economical, very clean, contaminate-free closure designed to fit most 12 x 32mm (2ml) HPLC and GC vials.
Their proprietary one piece polymer blend and unique sealing cone assures the lightest puncture force and best sealing system for a low cost, single piece cap. Since there is no split septa, the caps can be used for either analysis or for long term storage with no evaporative loss. No septa means no failed samples due to septa dislodging into vial. And no silicone means no worries about potential unidentifiable peaks from silicone layer contaminants, especially using LC/MS.
Read MoreRenishaw and Bruker Team up for a Workshop on TERS and Co-Localised AFM RamanMar 23, 2015
Renishaw, a world leader in metrology and spectroscopy technologies, has teamed up with Bruker's Nano Surfaces Division to host a series of workshops on TERS and co-localised AFM Raman.
The latest workshop took place at the end of January at Renishaw's headquarters at New Mills, Wotton-under-Edge, UK. Other workshops are planned to take place throughout the world. An audience of spectroscopists and microscopists recently attended the joint workshop designed to illustrate how to make tip-enhanced Raman spectroscopy more accessible to users. Four talks on the techniques, backed by various applications examples...
High performance liquid chromatography requires extremely accurate pumping systems delivering an accurate, precise and pulse-free flow of the mobile phase.
An HPLC pump system is a complex device with multiple moving parts subject to wear. Standard operating procedures should be in place to both minimize wear such as caused by particulate matter settling in valves and other components, and having spares on hand to replace components subject to wear (i.e. valves, piston and piston seal components). As one of many maintenance steps it is always a good idea to flush your HPLC system with rinse solvents after analysis with...
The PREP Symposium strives to provide the participants with a stage to present and discuss the very latest scientific and technological advances in preparative and process chromatography, with an exposure to the latest chromatography products available on the market, and with opportunities for training and continuing education.
Researchers with new results in areas relevant to the meeting topics are encouraged to submit abstracts online. We are striving to ensure the broadest possible coverage and exchange of recent advances. Please go to the link to "Key Dates" and "Topics" to see abstract submission deadlines. The meeting will include: A Strong Applications-Oriented Workshop Program, A Vendor Exhibit Providing Access to the Latest Advances on...
The VS20 WAVE from Cleaver Scientific is a single tank electrophoresis system which provides a fully integrated solution for vertical PAGE, tube gel IEF and electro blotting.
Interchangeable modular inserts on the innovative VS20 WAVE allow users to combine vertical PAGE with capillary gel IEF to perform 2D electrophoresis, followed by Western transfer for enhanced sensitivity. In addition to unmatched operational versatility the VS20 WAVE also offers ultra-fast set-up. Proprietary vertical screw-clamp technology reduces the number of screws required for set up compared to traditional electrophoresis systems, thereby dramatically reducing assembly time. The ergonomic design of the VS20 WAVE aids both handling and set-up, while its built-in inner buffer chamber allows set-up to be completed without the inclusion of a top tank or upper buffer chamber....
Read MoreCheminert High Pressure Fittings for 360 Mar 16, 2015
VICI Valco’s Cheminert High Pressure PEEK?Fittings are rated at 5000 psi with fingertight nuts, well beyond the burst strength of most PEEK tubing.
The taper angle and detail design conform to the industry standard established by the Valco line. The Cheminert UHPLC Fitting designs permit direct connection of 360 micron OD fused silica, PEEK, stainless, or electroformed nickel tubing without having to use troublesome liners. Because of the fitting’s compact size and fine 2-56 threads, a leak-free connection that seals at pressures well in excess of 20,000 psi can be easily formed with...
At the European Winter Conference on Plasma Spectrochemistry in Münster the Company launches two new mass spectrometers for its global sales
Analytik Jena AG expands its product range: only half a year after the acquisition of the ICP-MS business of the Bruker Corporation in September 2014, Analytik Jena introduces two new ICP-MS products (inductively coupled plasma for use in mass spectronomy) PlasmaQuant ® MS and PlasmaQuant ® MS Elite.The instruments will be unveiled at the European Winter Conference on Plasma Spectrochemistry (EWCPS)...
Genevac has launched a web page that brings together the latest technological innovations and application advances, with links to reference papers, detailing how new fast, safe evaporative sample preparation techniques are benefiting metabolism and toxicology studies.
Visitors to the new web page can gain an insight into how Genevac evaporators are providing fast, safe sample preparation, free from artefact, contamination or loss, from simple concentration or drying of solvent extracts from tissue samples right through to quantitative screening of workers or athletes for the presence of a drug...
Magritek, a leading provider of compact NMR and MRI instruments, report on the use of their Spinsolve Benchtop NMR spectrometer for reaction monitoring studies in the Cronin Group in the Chemistry Department of the University of Glasgow.
Professor Lee Cronin holds the Regius Chair of Chemistry at the University of Glasgow. Research in the Cronin Group is motivated by the fascination for complex chemical systems and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks. They are developing a new approach to the chemical sciences which they call Chemical Cybernetics. This combines...
A new whitepaper from Malvern Instruments provides detailed guidance on the analytical technologies that help to accelerate oral solid dosage (OSD) product formulation to a successful conclusion.
‘Analytical techniques with a place in the oral solid dosage formulation toolkit’ reviews the regulatory and QbD framework associated with OSD formulation and demonstrates how Malvern systems can be used to generate the data required. The goal of formulation is to incorporate an identified drug substance into a successful pharmaceutical product. The regulatory framework for OSD products highlights the need to comprehensively...
Flame brings flexible sensing power to research and teaching labs
Ocean Optics has launched a spectrometer line that combines decades of miniature spectrometer design expertise with industry-leading manufacturing techniques. The Flame spectrometer delivers high thermal stability and low unit to unit variation without compromising the flexibility and configurability that are the hallmark of modular, miniature spectrometers. Features such as interchangeable slits, indicator LEDs and simpler device...
Taking pictures with your camera you may find that images often look okay on a first glimpse, but when zooming in fine details are barely noticeable.
In contrast, the high information density of high resolution images will reveal even the smallest details. Since the introduction of ICP optical emission spectrometry, the spectral resolution has been a main concern with respect to accuracy and sensitivity. The wealth of emission lines from the plasma frequently leads to overlapping between lines of the analyte and that of accompanying elements. In many sample matrices such spectral interferences...
ACE UltraCore SuperC18 has been specifically designed for demanding MS application work and is based on high efficiency, low back pressure solid-core particles with a unique Encapsulated Bonding Technology (EBT).
This technology dramatically increases ligand coverage on the solid-core silica surface and consequently provides a number of key advantages for MS users. Advantage Number 1 for MS Users: Improved Peak Shape and MS Signal Intensity - ACE UltraCore SuperC18 columns have earned a well deserved reputation for delivering highly efficient symmetrical peaks, even with the most challenging of molecules. The use of a highly efficient column exhibiting minimal peak tailing will result in an improved MS signal response.....
Cogent Diol and Cogent UDA (undecanoic acid) are the latest additions to the MicroSolv range of stationary phases for high performance liquid chromatography (HPLC). Both columns are based on MicroSolv’s unique TYPE-C Silica and silica hydride surface chemistry.
Cogent Diol is a 4um diol bonded phase suitable for the reversed-phase or aqueous normal-phase (ANP) analysis of polar compounds and is LC-MS compatible. Columns show fast equilibration between gradient runs and can be successfully used in studies of pathways in human pathology.
The Qsep100 DNA Analyzer from Precision Biosystems performs rapid, high sensitivity assays at lower cost per sample compared to similar systems.
Capillary gel electrophoresis technology is recognized as an optimal approach to performing post PCR separation, detection of DNA and RNA fragments and assessing the quality of genomic DNA. The Qsep100 DNA Analyzer, by Precision Biosystems, uses micro-capillary gel electrophoresis combined with fluorescence detection, and is capable of performing 200 assays automatically as quickly as 2 minutes per sample. With costs per sample as low as $0.10 each, Qsep100 is...
Thermo Scientific MAbPac HIC-20 and MAbPac HIC-Butyl Columns Join Lineup
Laboratories characterizing monoclonal antibodies (mAb) now have additional hydrophobic interaction chromatography (HIC) selectivity options, thanks to the expanded family of Thermo Scientific MAbPac HIC HPLC columns. New Thermo Scientific MAbPac HIC-20 and MAbPac HIC-Butyl columns join the company’s line of columns for monoclonal antibody analysis, a response to customer demand for additional selectivity options for...
Advanced Chromatography Technologies Limited have launched new 0.5mm and 1.0mm i.d. microbore ACE UltraCore columns, based on high efficiency, low back pressure solid-core particles with unique Encapsulated Bonding Technology (EBT). These columns have been specifically designed for demanding MS application work and deliver extremely efficient, highly symmetrical peak shapes, which ensures improved MS signal intensity. The SuperC18 phase is...
J. G. Finneran Vial Loaders, manufactured from environmentally-friendly, recycled materials, provide a fast and convenient way of loading vials into all of your 96-well plates.
Finneran Vial Loaders are available with conical or flat bottom polypropylene or glass vials for our patented Multi-TierTM Micro Plate System, or glass conical or tapered bottom vials for many popular 96-Square Deep Well plates. Insert volume sizes range from 350µL glass conical, 6x32mm pulled-point inserts, to volumes of 2.0mL. The inserts are available in clear or amber, with an optional marking spot for easier sample identification....
The MiniVap™ blowdown evaporator from Porvair Sciences takes just minutes to remove volatile organic solvents from your 96-well microplates.
The MiniVap™ is the perfect tool for labs where smaller numbers of individual plates need drying. Incorporating advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each well of a 96-well microplate simultaneously, the MiniVap enables researchers to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates prior to analysis or reconstitution in buffer...
Merck Millipore, the Life Science business of Merck, today announced the introduction of its AFS® 40E / 80E / 120E and 150E water purification systems.
These new systems have been developed to provide clinical laboratories with an economical and reliable water purification solution for daily water volumes of up to 3000 L. The AFS® 40E / 80E / 120E and 150E systems rely on two powerful technologies to produce water quality meeting Clinical and Laboratory Standards Institute® (CLSI®) Clinical Laboratory Reagent Water standards. State-of-the-art, proven Elix® electrodeionization (EDI) technology ensures constant water quality...
“Delegates were particularly enthusiastic about OMNISEC’s sensitivity,” said Paul Clarke, Industrial Portfolio Manager at Malvern Instruments. “Announcing ‘the most sensitive light scattering detector on the market’ is one thing but seeing what that actually means in practice is another. Demonstrations of the system measuring the molecular weight (MW) of a 100,000 Da Polystyrene standard with just a 100 ng of sample made a big impression and...
Their proprietary one piece polymer blend and unique sealing cone assures the lightest puncture force and best sealing system for a low cost, single piece cap. Since there is no split septa, the caps can be used for either analysis or for long term storage with no evaporative loss. No septa means no failed samples due to septa dislodging into vial. And no silicone means no worries about potential unidentifiable peaks from silicone layer contaminants, especially using LC/MS.
The latest workshop took place at the end of January at Renishaw's headquarters at New Mills, Wotton-under-Edge, UK. Other workshops are planned to take place throughout the world. An audience of spectroscopists and microscopists recently attended the joint workshop designed to illustrate how to make tip-enhanced Raman spectroscopy more accessible to users. Four talks on the techniques, backed by various applications examples...
An HPLC pump system is a complex device with multiple moving parts subject to wear. Standard operating procedures should be in place to both minimize wear such as caused by particulate matter settling in valves and other components, and having spares on hand to replace components subject to wear (i.e. valves, piston and piston seal components). As one of many maintenance steps it is always a good idea to flush your HPLC system with rinse solvents after analysis with...
Researchers with new results in areas relevant to the meeting topics are encouraged to submit abstracts online. We are striving to ensure the broadest possible coverage and exchange of recent advances. Please go to the link to "Key Dates" and "Topics" to see abstract submission deadlines. The meeting will include: A Strong Applications-Oriented Workshop Program, A Vendor Exhibit Providing Access to the Latest Advances on...
The taper angle and detail design conform to the industry standard established by the Valco line. The Cheminert UHPLC Fitting designs permit direct connection of 360 micron OD fused silica, PEEK, stainless, or electroformed nickel tubing without having to use troublesome liners. Because of the fitting’s compact size and fine 2-56 threads, a leak-free connection that seals at pressures well in excess of 20,000 psi can be easily formed with...
Analytik Jena AG expands its product range: only half a year after the acquisition of the ICP-MS business of the Bruker Corporation in September 2014, Analytik Jena introduces two new ICP-MS products (inductively coupled plasma for use in mass spectronomy) PlasmaQuant ® MS and PlasmaQuant ® MS Elite.The instruments will be unveiled at the European Winter Conference on Plasma Spectrochemistry (EWCPS)...
Visitors to the new web page can gain an insight into how Genevac evaporators are providing fast, safe sample preparation, free from artefact, contamination or loss, from simple concentration or drying of solvent extracts from tissue samples right through to quantitative screening of workers or athletes for the presence of a drug...
Professor Lee Cronin holds the Regius Chair of Chemistry at the University of Glasgow. Research in the Cronin Group is motivated by the fascination for complex chemical systems and the desire to construct complex functional molecular architectures that are not based on biologically derived building blocks. They are developing a new approach to the chemical sciences which they call Chemical Cybernetics. This combines...
‘Analytical techniques with a place in the oral solid dosage formulation toolkit’ reviews the regulatory and QbD framework associated with OSD formulation and demonstrates how Malvern systems can be used to generate the data required. The goal of formulation is to incorporate an identified drug substance into a successful pharmaceutical product. The regulatory framework for OSD products highlights the need to comprehensively...
Ocean Optics has launched a spectrometer line that combines decades of miniature spectrometer design expertise with industry-leading manufacturing techniques. The Flame spectrometer delivers high thermal stability and low unit to unit variation without compromising the flexibility and configurability that are the hallmark of modular, miniature spectrometers. Features such as interchangeable slits, indicator LEDs and simpler device...
In contrast, the high information density of high resolution images will reveal even the smallest details. Since the introduction of ICP optical emission spectrometry, the spectral resolution has been a main concern with respect to accuracy and sensitivity. The wealth of emission lines from the plasma frequently leads to overlapping between lines of the analyte and that of accompanying elements. In many sample matrices such spectral interferences...
This technology dramatically increases ligand coverage on the solid-core silica surface and consequently provides a number of key advantages for MS users. Advantage Number 1 for MS Users: Improved Peak Shape and MS Signal Intensity - ACE UltraCore SuperC18 columns have earned a well deserved reputation for delivering highly efficient symmetrical peaks, even with the most challenging of molecules. The use of a highly efficient column exhibiting minimal peak tailing will result in an improved MS signal response.....
Cogent Diol is a 4um diol bonded phase suitable for the reversed-phase or aqueous normal-phase (ANP) analysis of polar compounds and is LC-MS compatible. Columns show fast equilibration between gradient runs and can be successfully used in studies of pathways in human pathology.
Capillary gel electrophoresis technology is recognized as an optimal approach to performing post PCR separation, detection of DNA and RNA fragments and assessing the quality of genomic DNA. The Qsep100 DNA Analyzer, by Precision Biosystems, uses micro-capillary gel electrophoresis combined with fluorescence detection, and is capable of performing 200 assays automatically as quickly as 2 minutes per sample. With costs per sample as low as $0.10 each, Qsep100 is...
Laboratories characterizing monoclonal antibodies (mAb) now have additional hydrophobic interaction chromatography (HIC) selectivity options, thanks to the expanded family of Thermo Scientific MAbPac HIC HPLC columns. New Thermo Scientific MAbPac HIC-20 and MAbPac HIC-Butyl columns join the company’s line of columns for monoclonal antibody analysis, a response to customer demand for additional selectivity options for...
Advanced Chromatography Technologies Limited have launched new 0.5mm and 1.0mm i.d. microbore ACE UltraCore columns, based on high efficiency, low back pressure solid-core particles with unique Encapsulated Bonding Technology (EBT). These columns have been specifically designed for demanding MS application work and deliver extremely efficient, highly symmetrical peak shapes, which ensures improved MS signal intensity. The SuperC18 phase is...
Finneran Vial Loaders are available with conical or flat bottom polypropylene or glass vials for our patented Multi-TierTM Micro Plate System, or glass conical or tapered bottom vials for many popular 96-Square Deep Well plates. Insert volume sizes range from 350µL glass conical, 6x32mm pulled-point inserts, to volumes of 2.0mL. The inserts are available in clear or amber, with an optional marking spot for easier sample identification....
The MiniVap™ is the perfect tool for labs where smaller numbers of individual plates need drying. Incorporating advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each well of a 96-well microplate simultaneously, the MiniVap enables researchers to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from microplates prior to analysis or reconstitution in buffer...
These new systems have been developed to provide clinical laboratories with an economical and reliable water purification solution for daily water volumes of up to 3000 L. The AFS® 40E / 80E / 120E and 150E systems rely on two powerful technologies to produce water quality meeting Clinical and Laboratory Standards Institute® (CLSI®) Clinical Laboratory Reagent Water standards. State-of-the-art, proven Elix® electrodeionization (EDI) technology ensures constant water quality...