YMC-Triart C18 UHPLC columns with an ID of 1 mm are the ideal choice for high sensitivity LC/MS analyses. In this new application note, the screening of 6 antineoplastic drugs is shown. This analysis requires the highest sensitivity since even the smallest amounts of these drugs need to be detected due to their adverse very serious, life-threatening effects. By choosing a high efficiency column with a small internal diameter of 1 mm and coupling it to mass spectrometry the benefit becomes clear: excellent peak shapes – also for low sensitivity compounds!
The use of only one SEC column brings a certain limitation due to its dedicated pore size and a limited column volume. By coupling two columns this hurdle can be overcome. Doubling the column length implies a doubled column volume which results in improved resolution of peaks. Additionally, if using two columns with different pore size, the applicable molecular weight range can be increased significantly....
A Schlenk Line is a tubular glass apparatus commonly used in chemistry or material laboratory research to carry out experiments under a vacuum and an inert atmosphere (like nitrogen or argon). It is used when samples are sensitive to air/moisture and the vacuum is also often used to remove the last traces of solvent from a sample. A Schlenk Line typically contains a dual glass manifold with multiple ports; the number of ports is configurable....
For decades, fluorescence microscopy has been an invaluable tool in life sciences research, with new variations and implementations emerging almost every year. Laser scanning microscopy, airyscanning, structured illumination, light field and light sheet microscopy are among the many methods that have been developed through the years to overcome the limitations of the original widefield microscopy setups...
Are you plagued with poor peak shapes, low sensitivities, sample carry over and/or low recoveries for challenging compounds. Several substances are able to interact with the usual inert column hardware materials such as stainless steel or titanium. The adsorption on metallic surfaces typically leads to peak tailing, loss of recovery and sample carry over. Critical substances are especially metal-coordinating compounds, such as fumonisins, sphingophospholipids or organophosphates in general....
To protect consumers and patients, the filling weight of finished goods and drugs must be checked gravimetrically. Uniformity of dosage unit measurements ensure that the mean weight meets the specified nominal package contents and is within permissible tolerances in order to avoid over- and underdosing. Average weight control prevents underfilling of prepacked goods...
Excellims Corporation (Excellims), a leading provider of high performance ion mobility spectrometers (High Performance IMS) and Compact Ion Mobility Mass Spectrometry (MS), signals its commitment to the pharmaceutical industry with the introduction of GMP-compliant at-line PAT (process analytical technology) and an increasing body of literature demonstrating its value in pharmaceutical applications...
As the demand for rapid SARS-CoV-2 testing continues to grow, so does the need for accurate, reliable and fast results. Gilson’s new COVID-19 Testing Fluid News Brochure highlights their range of world-renown and trusted manual and automated lab solutions that can easily integrate into your qPCR and RT-Lamp testing workflows. When protection, speed of analysis, reliability and traceability are paramount, Gilson’s range of lab equipment and instruments delivers verifiable data and complete confidence in results...
The Government Chemist (GC), hosted at LGC, has published the results of a recent international ring trial on the determination of cannabidiol (CBD) - an uncontrolled cannabinoid- and controlled cannabinoids in consumer products such as food and cosmetics. Consumer CBD products have entered the UK market rapidly in a variety of forms, including food and cosmetics. CBD when used as an ingredient in food or cosmetic products must currently be free from controlled cannabinoids....
As the COVID-19 pandemic continues, the worldwide search for an effective treatment is still ongoing. Remdesivir and GS-441524 are antiviral drugs that have been examined for the treatment of COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Remdesivir is a nucleotide analogue inhibitor that can inhibit the replication of animal and human coronaviruses...
A new eBook from Freeman Technology, a Micromeritics company and global leader in powder characterisation, explores the application of powder flow measurements for monitoring and optimising granulation processes. Granulation is a vital unit operation for many industries, notably the pharmaceutical sector, but endpoint detection and scale-up remain a challenge. ‘Powder Flow Testing for Granulation Processes’ focuses on the value of bulk powder characterisation...
Method of choice: The combination of size exclusion chromatography (SEC) and light scattering detection (LS) determines molecular weight, especially for higher molecular species such as aggregates or oligomers. As an additional plus sample size and topology can also be revealed. Special attention needs to be turned to the quality of SEC columns in order to provide signals unaffected by spikes. YMC’s SEC columns support LS-detection perfectly due to a high level of inertness...
BioChromato Inc. has published a report describing how their ionRocket sample preparation device, used in combination with Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Kendrick Mass Defect (KMD) analysis, provides a valuable new tool for chain analysis of fluoroelastomers. Because of their excellent heat, chemical and abrasion resistance - fluoropolymers are widely used in automotive parts and many other industrial products....
This guide is for anyone working in a biobank or laboratory seeking a comprehensive and reliable way of identifying and tracking biological samples destined for long-term cryogenic storage in liquid nitrogen or ultra-low temperature freezers. The guide should impart the reader with a deeper understanding of the many attributes of a cryogenic label, the thought process behind choosing a label, the selection of labels in the LabTAG catalog, and how to integrate it all within your process....
Porvair Sciences Ultraseal Pro is the new fully automated heat-sealing instrument designed to consistently seal and protect a wide range of microplates and tubes. Protecting precious samples during storage and transportation is an essential final step for a wide range of laboratory and clinical applications. Of the various methods for sealing microplates, heat sealing has become the preferred option....
Have you ever experienced problems with a new method? Are your system suitability tests failing now for a method established years ago? Is is your HPLC column dying too fast? There are many possible reasons for these issues and their root cause can be hard to find. Our new (U)HPLC Troubleshooting Guide provides an easy breakdown of potential solutions for the most common issues in analytical liquid chromatography...
It is well known that flow properties of powders are governed by the intrinsic grain properties and forces acting on and between the grains. It is no surprise that the amount of API present in a blend impacts powder processability. To this end, GranuTools has developed, over the past years, a whole range of state-of-the-art equipments to allow characterizing the flow properties of powders and granular materials in many different geometries to match process conditions....
Are you dealing with demanding substances that tend to coordinate with metals? Are you looking for an inert solution for your peptide/protein, (oligo)nucleotide or sensitive small molecules? This is the solution for your problems! The bioinert YMC-Triart columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes for sensitive compounds. Check out YMC's new flyer to discover more about biocompatible YMC-Triart metal-free columns....
Download this free infographic from Thermo Fisher Scientific to learn about SARS-CoV-2 infection and replication, disease progression and spread of COVID-19, and the importance and types of COVID-19 testing. There are different types of technologies used to test for SARS-CoV-2. The two tests that are most often used are PCR and antigen. PCR is 99% accurate and detects viral ....
Analytik Jena has published a new e-book for water and wastewater analysis. It demonstrates efficient methods and solutions for a wide range of selected routine and special applications. The e-book focuses on some central areas of water and wastewater analysis: In addition to the analysis of TOC/TNb and AOX, elemental analysis, and UV/Vis spectroscopy, the e-book also highlights molecular biological detection solutions....
Porvair Sciences announce the availability of a new guide that makes selection of the optimum Solid Phase Extraction (SPE) microplate for your application both quick and easy. SPE is a widely used method of sample preparation that concentrates and purifies analytes from a solution by means of absorption, followed by the elution of the analyte with a solvent appropriate for instrumental analysis, with techniques such as LC-MS...
Cherwell Laboratories, specialist supplier of products for environmental monitoring and process validation, has drawn on its extensive pharmaceutical and related industry knowledge to publish an eBook titled, “Growth Promotion Testing: A Guide to Good Practices” which is available to download from Cherwell’s website. The guide is intended for anyone involved in growth promotion testing of microbiological media, providing an overview of key considerations and best practice for this key quality control (QC) test...
YMC-Triart C18 UHPLC columns with an ID of 1 mm are the ideal choice for high sensitivity LC/MS analyses. In this new application note, the screening of 6 antineoplastic drugs is shown. This analysis requires the highest sensitivity since even the smallest amounts of these drugs need to be detected due to their adverse very serious, life-threatening effects. By choosing a high efficiency column with a small internal diameter of 1 mm and coupling it to mass spectrometry the benefit becomes clear: excellent peak shapes – also for low sensitivity compounds!
The use of only one SEC column brings a certain limitation due to its dedicated pore size and a limited column volume. By coupling two columns this hurdle can be overcome. Doubling the column length implies a doubled column volume which results in improved resolution of peaks. Additionally, if using two columns with different pore size, the applicable molecular weight range can be increased significantly....
A Schlenk Line is a tubular glass apparatus commonly used in chemistry or material laboratory research to carry out experiments under a vacuum and an inert atmosphere (like nitrogen or argon). It is used when samples are sensitive to air/moisture and the vacuum is also often used to remove the last traces of solvent from a sample. A Schlenk Line typically contains a dual glass manifold with multiple ports; the number of ports is configurable....
For decades, fluorescence microscopy has been an invaluable tool in life sciences research, with new variations and implementations emerging almost every year. Laser scanning microscopy, airyscanning, structured illumination, light field and light sheet microscopy are among the many methods that have been developed through the years to overcome the limitations of the original widefield microscopy setups...
Are you plagued with poor peak shapes, low sensitivities, sample carry over and/or low recoveries for challenging compounds. Several substances are able to interact with the usual inert column hardware materials such as stainless steel or titanium. The adsorption on metallic surfaces typically leads to peak tailing, loss of recovery and sample carry over. Critical substances are especially metal-coordinating compounds, such as fumonisins, sphingophospholipids or organophosphates in general....
To protect consumers and patients, the filling weight of finished goods and drugs must be checked gravimetrically. Uniformity of dosage unit measurements ensure that the mean weight meets the specified nominal package contents and is within permissible tolerances in order to avoid over- and underdosing. Average weight control prevents underfilling of prepacked goods...
Excellims Corporation (Excellims), a leading provider of high performance ion mobility spectrometers (High Performance IMS) and Compact Ion Mobility Mass Spectrometry (MS), signals its commitment to the pharmaceutical industry with the introduction of GMP-compliant at-line PAT (process analytical technology) and an increasing body of literature demonstrating its value in pharmaceutical applications...
As the demand for rapid SARS-CoV-2 testing continues to grow, so does the need for accurate, reliable and fast results. Gilson’s new COVID-19 Testing Fluid News Brochure highlights their range of world-renown and trusted manual and automated lab solutions that can easily integrate into your qPCR and RT-Lamp testing workflows. When protection, speed of analysis, reliability and traceability are paramount, Gilson’s range of lab equipment and instruments delivers verifiable data and complete confidence in results...
The Government Chemist (GC), hosted at LGC, has published the results of a recent international ring trial on the determination of cannabidiol (CBD) - an uncontrolled cannabinoid- and controlled cannabinoids in consumer products such as food and cosmetics. Consumer CBD products have entered the UK market rapidly in a variety of forms, including food and cosmetics. CBD when used as an ingredient in food or cosmetic products must currently be free from controlled cannabinoids....
As the COVID-19 pandemic continues, the worldwide search for an effective treatment is still ongoing. Remdesivir and GS-441524 are antiviral drugs that have been examined for the treatment of COVID-19 caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Remdesivir is a nucleotide analogue inhibitor that can inhibit the replication of animal and human coronaviruses...
A new eBook from Freeman Technology, a Micromeritics company and global leader in powder characterisation, explores the application of powder flow measurements for monitoring and optimising granulation processes. Granulation is a vital unit operation for many industries, notably the pharmaceutical sector, but endpoint detection and scale-up remain a challenge. ‘Powder Flow Testing for Granulation Processes’ focuses on the value of bulk powder characterisation...
Method of choice: The combination of size exclusion chromatography (SEC) and light scattering detection (LS) determines molecular weight, especially for higher molecular species such as aggregates or oligomers. As an additional plus sample size and topology can also be revealed. Special attention needs to be turned to the quality of SEC columns in order to provide signals unaffected by spikes. YMC’s SEC columns support LS-detection perfectly due to a high level of inertness...
BioChromato Inc. has published a report describing how their ionRocket sample preparation device, used in combination with Direct Analysis in Real Time Mass Spectrometry (DART-MS) and Kendrick Mass Defect (KMD) analysis, provides a valuable new tool for chain analysis of fluoroelastomers. Because of their excellent heat, chemical and abrasion resistance - fluoropolymers are widely used in automotive parts and many other industrial products....
This guide is for anyone working in a biobank or laboratory seeking a comprehensive and reliable way of identifying and tracking biological samples destined for long-term cryogenic storage in liquid nitrogen or ultra-low temperature freezers. The guide should impart the reader with a deeper understanding of the many attributes of a cryogenic label, the thought process behind choosing a label, the selection of labels in the LabTAG catalog, and how to integrate it all within your process....
Porvair Sciences Ultraseal Pro is the new fully automated heat-sealing instrument designed to consistently seal and protect a wide range of microplates and tubes. Protecting precious samples during storage and transportation is an essential final step for a wide range of laboratory and clinical applications. Of the various methods for sealing microplates, heat sealing has become the preferred option....
Have you ever experienced problems with a new method? Are your system suitability tests failing now for a method established years ago? Is is your HPLC column dying too fast? There are many possible reasons for these issues and their root cause can be hard to find. Our new (U)HPLC Troubleshooting Guide provides an easy breakdown of potential solutions for the most common issues in analytical liquid chromatography...
It is well known that flow properties of powders are governed by the intrinsic grain properties and forces acting on and between the grains. It is no surprise that the amount of API present in a blend impacts powder processability. To this end, GranuTools has developed, over the past years, a whole range of state-of-the-art equipments to allow characterizing the flow properties of powders and granular materials in many different geometries to match process conditions....
Are you dealing with demanding substances that tend to coordinate with metals? Are you looking for an inert solution for your peptide/protein, (oligo)nucleotide or sensitive small molecules? This is the solution for your problems! The bioinert YMC-Triart columns are fully biocompatible due to their PEEK lined stainless steel column bodies and the use of PEEK frits. You can achieve excellent peak shapes for sensitive compounds. Check out YMC's new flyer to discover more about biocompatible YMC-Triart metal-free columns....
Download this free infographic from Thermo Fisher Scientific to learn about SARS-CoV-2 infection and replication, disease progression and spread of COVID-19, and the importance and types of COVID-19 testing. There are different types of technologies used to test for SARS-CoV-2. The two tests that are most often used are PCR and antigen. PCR is 99% accurate and detects viral ....
Analytik Jena has published a new e-book for water and wastewater analysis. It demonstrates efficient methods and solutions for a wide range of selected routine and special applications. The e-book focuses on some central areas of water and wastewater analysis: In addition to the analysis of TOC/TNb and AOX, elemental analysis, and UV/Vis spectroscopy, the e-book also highlights molecular biological detection solutions....
Porvair Sciences announce the availability of a new guide that makes selection of the optimum Solid Phase Extraction (SPE) microplate for your application both quick and easy. SPE is a widely used method of sample preparation that concentrates and purifies analytes from a solution by means of absorption, followed by the elution of the analyte with a solvent appropriate for instrumental analysis, with techniques such as LC-MS...
Cherwell Laboratories, specialist supplier of products for environmental monitoring and process validation, has drawn on its extensive pharmaceutical and related industry knowledge to publish an eBook titled, “Growth Promotion Testing: A Guide to Good Practices” which is available to download from Cherwell’s website. The guide is intended for anyone involved in growth promotion testing of microbiological media, providing an overview of key considerations and best practice for this key quality control (QC) test...