Horizon Discovery

publication date: Dec 5, 2017
 | 
author/source: Horizon Discovery Group

Horizon Discovery (LSE: HZD), a global leader in gene editing and gene modulation technologies, announces the launch of its reagent platform for CRISPR activation (CRISPRa) from its recently acquired Dharmacon™ business. This is the latest addition to the Company’s market-leading Edit-R™ portfolio for CRISPR-Cas9 genome engineering.

horizonThe new Edit-R CRISPRa offering provides researchers interested in gain-of-function studies with a powerful and easy-to-use two-component system for drug discovery, disease modeling, or pathway analysis. The straightforward system is available in lentiviral and synthetic formats and is well-suited for robust overexpression in virtually any cell system. This format is also highly amenable to arrayed studies for high-throughput, complex phenotypic analysis.

CRISPRa is a next-generation method to induce the expression of the endogenous (or native) form of the gene, and represents a transformative technology for gain-of-function studies. Previously, research tools for gene overexpression have been limited to expression plasmids, where the DNA encoding a gene is inserted into a carrier vector and introduced into cells. While effective, a CRISPRa-based system offers a more flexible and targeted system that promises to provide more reliable and relevant results.

The Edit-R CRISPRa portfolio includes genome-wide, pre-designed guide RNAs for human and mouse, as either a lentiviral expression plasmid, lentiviral particles, or a two-part synthetic guide RNA. The system further utilizes nuclease-deactivated Cas9 fused to three activation domains provided as lentiviral particles or purified plasmids.

Dr. Darrin M Disley, Chief Executive Officer, Horizon Discovery, commented: “These first-to-market, high-quality research reagents for CRISPRa are a powerful addition to the Edit-R portfolio, and further demonstrate our commitment to providing tools and services that support the advanced research that is driving the genomic revolution. These reagents are also highly complementary to Horizon’s CRISPRa screening services and so are a fantastic example of the combined solutions the Company offers to the research community.”


more about horizon


 



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.