Leica Microsystems announced today the availability of
Leica
ChromoPlex
TM 1 Dual Detection for BOND, the first fully automated one-step
detection system allowing the co-visualization of mouse and rabbit antibodies
on a single slide. Same day diagnosis is now easier to achieve when compared
with the two-step sequential or semi-automated processes currently available on
competitive IHC advanced stainers. Developed for use with commercial and
self-validated cocktails, ChromoPlex delivers the intense staining and clear
background that BOND users currently enjoy from Leica's Compact Polymer
technology.
"When tissue is limited and diagnostic decisions
are needed, the most effective use of tissue sections becomes imperative"
comments Konstantin Fiedler, Vice President of Advanced Staining for Leica
Microsystems. "The turnaround times achievable with our new ChromoPlex range
open the door to faster patient management, while maintaining the diagnostic
confidence pathologists demand to make the right decisions. Laboratories can
choose antibodies from different sources, ensuring the most effective
combinations of antibodies to aid diagnosis can always be used".
"The dual staining obtained using the ChromoPlex 1
detection system is attractive, crisp and consistent; ideal when assessing
challenging prostatic biopsies," states Dr Geoffrey Hulman MD FRCPath,
Consultant Histopathologist at Nottingham University Hospitals NHS Trust, where
the detection technology was evaluated in cooperation with the Nottingham
Health Science Biobank. Dr Claire Hawkes PhD, CSci comments that "historically,
we encountered problems with dual staining and efforts to stain up commercial
cocktails have been largely unsuccessful. The ChromoPlex 1 detection system,
however, enables quick easy staining of both commercial and in-house home-brew
cocktails, with excellent results."
ChromoPlex 1 Dual Detection is a biotin-free,
polymeric horseradish peroxidase (HRP)-linker and polymeric alkaline
phosphatase (AP)-linker antibody conjugate system for the detection of
tissue-bound mouse and rabbit IgG primary antibodies. The small multifunctional
linkers enhance tissue penetration, producing high sensitivity. The excellent
contrast between the Fast Red and DAB chromogens allows for easy antigen
differentiation.
ChromoPlex 1 Dual Detection for BOND is intended for
staining sections of formalin fixed, paraffin-embedded tissue for use on
Leica
BOND-MAX and
BOND-III
automated IHC staining systems. It can be used simultaneously with both
Novocastra
BOND Polymer Refine and
Polymer
Refine Red Detection, allowing unparalleled flexibility in staining
protocols and workflow efficiency.
ChromoPlex 1 Dual
Detection for BOND will be available for sale from December 1, 2011 in the
United States of America and the European Union. Devices advertised may not
have been licensed in accordance with Canadian law.For more information
click here
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