Follow us...

 

Search News Archives

News Channels

 

Coronavirus (COVID-19)

 

View Channel

New Laboratory Products

 

View Channel

Lab News

 

View Channel

Research & Case Studies

 

View Channel

Microscopy | Image Analysis

 

View Channel

Separation Science

 

View Channel

Videos

 

View Channel

Events | Webinars

 

View Channel

Conferences | Events

Syrris Asia Helps to Accelerate Spirocyclic Polyketide Synthesis

publication date: Dec 3, 2014
 | 
author/source: Syrris

Leys chemistry

The modular Asia flow chemistry system from Syrris proved key to the success of a recently described process for accelerated total synthesis of spirodienal A and spirangien A methyl ester.

Developed by the Ley Group at the Department of Chemistry, University of Cambridge, UK – and recently published in Angewandte Chemie International Edition1 – the groundbreaking work describes the use of powerful flow chemistry techniques for complex multi-stage synthesis of spirocyclic polyketides.

The flexible Asia system was crucial to the success of the study, offering a variety of flow techniques – including gas-liquid and solid phase chemistries, liquid-liquid extraction and continuous work-up – to enable faster reaction optimization and telescoping of reaction steps. Researchers benefitted from the Asia Pump’s capacity to smoothly handle low boiling point solvents, as well as rapid mixing and continuous work-up in glass microreactors with the advanced Asia FLLEX (Flow Liquid Liquid Extraction). This set-up allowed synthesis of essential, complex coupling fragments using newly developed flow chemistry methods for automated reagent addition, silylation, crotylation, ozonolysis, olefination and oxidation, allowing these vital building blocks to be produced faster and more safely, with higher yields compared to batch reactions.

1 Newton, S., Carter, C. F., Pearson, C. M., de C. Alves, L., Lange, H., Thansandote, P. and Ley, S. V. (2014), Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry. Angew. Chem. Int. Ed., 53: 4915–4920. doi: 10.1002/anie.201402056


more about syrris


more news from syrris


 

 

 



 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd

 

 

 

Media Partners