Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Closed Loop Reaction Optimisation

publication date: Oct 19, 2022
 | 
author/source: Uniqsis Ltd

closed-loop-reaction-optimisation 

Researchers at the University of Pretoria (South Africa) have developed a general platform for performing closed loop reaction optimisation by integrating a Uniqsis FlowSyn Maxi continuous flow reactor with an analytical HPLC. 

In the reported work the FlowSyn Maxi was controlled over ethernet using an open-source Node-Red dashboard running on a Raspberry Pi linked to the single objective optimisation algorithm.
 
Dr Mark Ladlow, Uniqsis Chief Scientific Officer commented “‘Optimising chemical reactions is an important but time-consuming iterative process. Flow chemistry affords an automated and precise method for performing chemical reactions that is well suited to performing autonomous reaction optimisation under computer control in a closed feedback loop using a suitable optimisation algorithm. Closed-loop control of a flow chemistry reactor is a sequential process whereby the result of each experiment is compared with the desired optimal outcome (in this case, the space-time yield of the reaction). A Bayesian optimisation algorithm then uses the new data to suggest an improved set of reaction conditions for the next experiment. Using real experimental data to update a probabilistic model for the reaction can allow the optimal outcome to be realised more quickly”.
 
The utility of the University of Pretoria open-source software approach, using the FlowSyn Maxi, was demonstrated by the semi-autonomous optimisation of a representative allylation reaction performed over 33 iterations in a 12-hour period. Beneficially, other Uniqsis flow chemistry instruments may be incorporated into the open-source dashboard to extend this approach to alternative system configurations, potentially capable of performing and optimising a wide range of chemical reactions.
 
Click HERE to read the University of Pretoria paper in full or for further information on closed loop reaction optimisation using a FlowSyn Maxi system please Click HERE

 

About Uniqsis 

Since 2007, Uniqsis has specialised in the design and supply of mesoscale continuous flow chemistry systems for a wide range of applications in chemical and pharmaceutical research. The company’s aim is to make flow chemistry easily accessible to both novices and experienced users. 

 

Recent news from Uniqsis

 


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events