Uniqsis has developed an extensive range of affordable ‘building block’ modules to which you can simply add your own pumps to create a flow chemistry system. Compatible with a wide range of existing hardware – Uniqsis reactor modules significantly lower the cost of setting-up a high-performance flow chemistry system. Beneficially you can invest in just the capabilities you need now while preserving the ability to expand your flow chemistry system in future without redundancy...
The FlowLab Column™ from Uniqsis is an affordable flow chemistry system designed specifically for high temperature and pressure catalysis applications. At the heart of the FlowLab Column™ is a HotCoil heated reactor module fitted with a HotColumn adapter to enable operation up to +260 °C (300 °C as an option). Developed as a high-performance alternative to conventional stirred batch reactors – the FlowLab Column™ can accommodate six stainless steel columns in individual insulated holders, each capable of operation up to 100 bar...
The new PHOTOCHIP™ high power LED photoreactor module from Uniqsis provides chemists with a benchmark tool to run photochemical reactions with highly efficient mixing and accurately controlled temperature. The PHOTOCHIP™ is an easy-to-use device - design optimised to perform photochemical reactions in the complete range of Uniqsis Glass Static Mixer (GSM) reactor blocks, also known as GSM chip reactors...
To enhance the reproducibility of flow chemistry scale-up - precise control of mixing and temperature in highly exothermic or rapid reactions in particular is essential. The expanding range of Glass Static Mixer (GSM) chip reactor blocks from Uniqsis produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent. Available in sizes from 270µl to 20 ml, the Uniqsis range of high-quality GSM chips can be used to perform reactions from -80°C to over 150°C...
Uniqsis report major growth in sales of its FlowSyn, FlowLab and modular based flow chemistry reactor systems to leading Chinese academic institutions. Most recently, local distributor - Beijing SMS has installed systems at ICCAS, Kunming University and Sichuan University. These academic institutions were interested in acquiring easy to use and maintain, high performance flow chemistry systems...
The Borealis™ from Uniqsis brings flow photochemistry within the budget of almost any laboratory. The Borealis™ sets a new benchmark for safe high yield photochemical flow synthesis. Equipped with a safety interlock, to prevent accidental exposure to high intensity light, the LED lamps (available in a range of fixed wavelengths - 370, 410, 440, 460 and 520nm), are powered by a programable power supply that automatically detects the wavelength of the Borealis™ LED module and adjusts the output characteristics accordingly..
At the forefront of flow reactor design, FlowSyn™ from Uniqsis sets the standard for automated optimisation of heterogeneous catalysis reactions. The use of solid supported reagents, catalysts and scavengers in flow reactor systems offers significant benefits over conventional batch heterogeneous catalysis techniques. Their use often avoids the need for downstream product purification and leads to enhanced reaction rates and higher overall efficiency due to the large excess of catalyst...
For synthesis labs looking to undertake small scale photochemical reactions – Uniqsis has introduced Solstice™ – a compact, temperature-controlled batch photoreactor that combines affordability, high-performance and flexibility. Solstice™ is the ideal photochemical synthesis tool for reactions involving solid materials (such as catalysis), optimisation of reaction conditions and production of small compound arrays...
The Uniqsis FlowLab Plus™ is a versatile flow chemistry system with a wide choice of high-performance modules to match your application needs. Designed around the proven Binary Pump™ dual channel reagent delivery system, the FlowLab Plus™ can be configured to run both manual and automated flow chemistry reactions. This versatile system may be configured with any combination of up to 4 individual reactor modules....
Uniqsis reports that demand for its Flow-UV inline UV-Visible spectrophotometer for biological, biotech, drug discovery and industrial applications grew to record levels during 2022. Compact in design, the Flow-UV from Uniqsis sets a benchmark for real time monitoring of continuous flow and batch applications. Unlike many UV-visible spectrophotometers the high-resolution Flow-UV CCD array detector does not require calibration or routine servicing...
Used in conjunction with an external thermoregulation circulator, the Cold Coil II™ flow reactor module from Uniqsis can maintain stable temperatures between -78°C and +150°C for extended periods of time. Proven to provide a flexible, entry-level solution for low temperature flow chemistry applications the Cold Coil II™ includes a glass cover to eliminate convective effects within fume cupboards...
Uniqsis offers a range of reactor modules designed to enable labs, with a limited budget, to build flow chemistry systems without compromising performance considerations. The Cold Coil II™ Flow Reactor Module is designed to provide a flexible, entry-level solution for low temperature flow chemistry applications. Used in conjunction with an external thermoregulation circulator the Cold Coil II™ can maintain stable temperatures between -78°C and +150°C for extended periods of time....
The Uniqsis PhotoSyn™ LED photoreactor eliminates problems associated with traditional batch methods enabling synthetic chemists to routinely scale-up their photochemistry reactions from milligrams to several kilograms / day. The PhotoSyn™ is designed to provide scientists with a high-power LED light source for continuous flow applications...
The PhotoSyn™ high power LED photoreactor, from Uniqsis, eliminates problems associated with traditional batch methods enabling synthetic chemists to routinely scale-up their photochemistry reactions from milligrams to several kilograms / day. The PhotoSyn™ is designed to provide scientists with a high-power LED light source for continuous flow applications...
Researchers at the University of Pretoria (South Africa) have developed a general platform for performing closed loop reaction optimisation by integrating a Uniqsis FlowSyn Maxi continuous flow reactor with an analytical HPLC. In the reported work the FlowSyn Maxi was controlled over ethernet using an open-source Node-Red dashboard running on a Raspberry Pi linked to the single objective optimisation algorithm...
Uniqsis has launched ColdChip™ - a new versatile mixer/reactor module enabling researchers to experiment with different chemistries particularly exothermic reactions that need to be safely run in a cooled environment with highly efficient mixing. Compact in design, and requiring no input power, the ColdChip™ is optimised for use with the Uniqsis FlowSyn and FlowLab range of flow reactors as well as standalone pumps....
The Uniqsis Polar Bear Plus Flow™ is a compact, state of the art temperature control module, that can be used as a standalone unit or integrated with a flow reactor, for both heated and cooled flow chemistry applications. Utilising highly efficient, compressor-based cooling and heating technology the Polar Bear Plus Flow™ can precisely and reliably maintain reactor temperatures anywhere between -40?C and +150?C. The module is easy to use and is completely self-contained, requiring only an electricity supply for operation...
The FlowSyn Maxi™ from Uniqsis is a high throughput flow reactor for process chemists looking to optimise reaction conditions before scaling-up synthetic production to multiple kilograms per day. Combining the benefits of proven FlowSyn technology with the capability to run at high flow rates (up to 100 ml/min) in a compact benchtop design - the FlowSyn Maxi™ sets a new standard for higher throughput applications...
The FlowLab Column from Uniqsis is a continuous flow chemistry system developed as an affordable high-performance replacement for conventional stirred batch reactors often used for heterogeneously catalysed liquid phase reactions. Designed to provide highly efficient mixing and excellent control over reaction parameters, the FlowLab Column provides intimate contact between a large excess of catalyst and a small quantity of reagent at any point in time resulting in increased reaction rates and higher yields....
Borealis™ from Uniqsis is a new high intensity LED lamp unit, available in a range of fixed wavelengths (370, 410, 440, 460 and 520nm), that converts their Cold Coil™ standalone reactor module into a flow reactor for photochemical applications. Both the Borealis™ LED lamp and the Cold Coil™ reactor modules require liquid cooling from either a piped water supply or a closed loop recirculator...
To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Uniqsis expanding range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent...
Specialists in flow chemistry - Uniqsis has introduced the Photochemistry LED Illuminator – a new tool to accelerate reaction optimization and batch scale-up of photochemical reactions. The new illumination system incorporates LED arrays operating at 6 different wavelengths from 365 – 525nm. The LEDs are mounted on cassettes for easy interchangeability, in industry-standard 24 or 48 well configurations....
Uniqsis makes flow chemistry accessible to everyone, while at the same time catering for multi-step and automated reactions sequences, through the availability of an expanding suite of affordable 'plug and play' reactor modules. Compatible with all Uniqsis coil reactors and with an operating temperature range of ambient to +300°C, the HotCoil™ reactor heating module represents a cost-effective entry solution into flow chemistry....
The Uniqsis range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent. To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Now available in sizes from 270µl to 20 ml, the recently expanded range of GSM chips from Uniqsis can be used to perform reactions from -80°C to over 150°C...
Uniqsis offers an extensive range of individual flow chemistry modules that can be used on any flow chemistry system.These convenient, high quality, plug-and-play modules have been designed to enable researchers to configure a flow chemistry system precisely to meet their needs. Uniqsis flow chemistry modules include a comprehensive range of...
Uniqsis reports on two major orders for its FlowSyn™ flow chemistry systems from organisations involved with the South African Pharmaceutical Industry. In the pharmaceutical sector, industry growth in the emerging world is rapidly outpacing mature markets like Europe and the US. Although at present the pharma industries across Africa account for just 2% of the global medicines market....
Uniqsis reports on how its Flow-UV™ inline UV-Visible spectrometer sets a new benchmark for real-time dispersion and nanoparticle distribution and agglomeration experiments. Designed for use with almost any commercially available flow chemistry system, Flow-UV™ allows dispersion experiments to be monitored in real time so that product collection can be controlled...
The renowned Innovative Technology Centre (ITC) at the University of Cambridge, UK has used a Uniqsis PhotoSyn flow photoreactor to efficiently scale-up a radical mediated boronic acid coupling under photoredox conditions using a novel organic acridium-based photocatalyst. The acridium-based organic photocatalyst, developed by the University of Cambridge, is demonstrated to be an efficient replacement for iridium-based photocatalysts used to oxidise boronic acid derivatives by a single electron radical coupling process....
Uniqsis has introduced the Polar Bear Plus GSM™ - a versatile heating and cooling reactor module for flow chemistry applications using Glass Static Mixers / Reactor Chips (GSMs). To achieve high reproducibility and facilitate scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Uniqsis glass static mixer / reactor chips produce an efficient, turbulent mixed reagent stream...
Uniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. FlowLab Plus™ is a versatile flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry reactions....
Uniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. FlowLab Plus™ is a versatile flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry...
Uniqsis reports how the Institute of Physics at the University of Tartu (Estonia) has selected a FlowSyn™ continuous flow reactor with Flow-UV™ detector to assist them in development of novel nanomaterials for use in next generation applications. The material science research group of Dr Aile Tamm evaluated different technological approaches to synthesise nanomaterials before investing in the Uniqsis FlowSyn system...
The Uniqsis PhotoSyn™ is a new high-power LED light unit enabling scalable flow photochemistry reactions yielding from milligrams to 100’s of grams per day. By eliminating the control, scale-up and safety problems associated with traditional batch photochemistry – the Uniqsis PhotoSyn™ enables synthetic chemists to routinely take full advantage of the many benefits offered by photochemistry...
Uniqsis announces HotChip™ - a new standalone heater module that provides precise temperature control of flow chemistry glass static mixer (GSM) chip reactors. The Uniqsis range of chemically-resistant borosilicate glass chip reactor blocks can be used as static mixers to ensure effective mixing before a coil reactor or to perform fast exothermic experiments such as nitration’s or bromination’s where reaction times are often less than 1 minute...
Uniqsis,, a market leader in flow chemistry, reports following excellent business growth in 2017 that it has recruited a further sales / support specialist to be located at its office in Cambridge. Paul Pergande, Managing Director of Uniqsis commented "We are very pleased to welcome Steve Evans to Uniqsis. Steve's strong technical background as well as his in-depth knowledge of continuous flow reactor equipment and applications will be a major asset to both Uniqsis and its customers worldwide"....
Uniqsis reports how chemists at the School of Pharmacy, University College London (UK) have been using a FlowSyn™ continuous flow reactor system.
Flow chemistry is an ideal approach to chemical synthesis where reactions can readily be optimised via simple iterations and can easily be scaled up. However, one of the challenges are the associated costs and fixed formats of the reactors themselves.....
Uniqsis has published an application note that describes an efficient 2-step synthesis of a library of pyrazoles under continuous flow-through conditions developed by chemists at GalChimia (Coruna, Spain) on a FlowSyn™ continuous flow reactor system.
Pyrazoles are an important and well represented chemotype in drug discovery displaying wide ranging biological actions that include analgesic, anti-inflammatory, antipyretic, tranquilizing, muscle relaxing, anticonvulsant, antidiabetic and antibacterial activities....
Uniqsis has introduced FlowLab Column™ – an optimised flow chemistry system for heterogeneous catalysis applications.
Catalysts can be divided into two main types - heterogeneous and homogeneous. In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....
Uniqsis has introduced FlowLab Column™ – an optimised flow chemistry system for heterogeneous catalysis applications.
Catalysts can be divided into two main types - heterogeneous and homogeneous. In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....
A leading Contract Research and Development Organisation (CRDO) – Arcinova has invested in a Uniqsis FlowSyn™ continuous flow reactor enabling them to develop and simplify the scale-up of a challenging API batch process.
Following a trial of the FlowSyn™ system – Arcinova could justify their investment based upon rapid synthetic method development and the considerable cost and time savings demonstrated versus using large scale reactor vessels for the selected process. Dr. Samuel Bourne, Continuous Manufacturing Lead at Arcinova commented...
Uniqsis has published details of a new flow-through protocol developed by the Lamaty Group at Universite de Montpellier (France) on a FlowSyn™ Multi-X system that provides efficient ring closing olefin metathesis.
Olefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility....
Uniqsis has published details of a new flow-through protocol developed by the Lamaty Group at Universite de Montpellier (France) on a FlowSyn™ Multi-X system that provides efficient ring closing olefin metathesis.
Olefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility. While several research groups have reported the development of olefin metathesis in continuous flow, most of them have focused on the use of a heterogeneous catalyst....
Available in a choice of configurations the Uniqsis FlowLab™ range are affordable and easy-to-use flow chemistry systems ideal for use in research, education and for those wishing to try flow chemistry without the associated costs of a fully automatic system.
Built around the same high quality components as used in the widely acclaimed Uniqsis FlowSyn™ system, both the FlowLab™ and FlowLab Cold™ offer uncompromised performance at an entry-level price. The FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control computer...
Available in a choice of configurations the Uniqsis FlowLab™ range are affordable and easy-to-use flow chemistry systems ideal for use in research, education and for those wishing to try flow chemistry without the associated costs of a fully automatic system.
Built around the same high quality components as used in the widely acclaimed Uniqsis FlowSyn™ system, both the FlowLab™ and FlowLab Cold™ offer uncompromised performance at an entry-level price....
Uniqsis Ltd has introduced Flow-UV™ - an affordable in-line UV-Visible spectrophotometric detector for flow chemistry applications.
Designed for use with almost any commercial flow chemistry system - the compact Flow-UV™ detector (18 x18 x 17cm) fits conveniently into even crowded fume cupboards. Using the UV-visible absorbance data from a Flow-UV™ detector allows dispersion experiments to be monitored in real time and enables product collection to be controlled according to the onset and decline of steady state conditions....
Uniqsis Ltd., specialists in flow chemistry, has announced a 50% growth in sales and a significant increase in trading profit for their business year ending 31st January 2017.
During the year – Uniqsis achieved strongest growth in North America and Europe with a notable increase in sales of its high performance FlowSyn integrated continuous flow reactor systems for pharmaceutical, nanomaterials and academic research applications....
FlowLab™ and FlowLab Cold™ are affordable and easy-to-use flow chemistry systems ideal for research, education and training and for those wishing to try flow chemistry without the associated costs of a sophisticated fully automatic system.
The FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be controlled remotely by Wi-Fi, allowing the control computer to be conveniently operated outside the fume hood....
FlowStart™ is an affordable and easy-to-use entry level flow chemistry system that is ideal for education, training and for those wishing to try flow chemistry without the associated costs of a sophisticated fully automatic system.
The system comprises two high pressure pumps, aHotCoil™ coil reactor station and FlowStart™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be operated by Wi-Fi allowing the control computer to be conveniently operated outside the fume hood. The FlowStart™ application provides control of the system via a step-through interface that is straightforward...
FlowStart™is an affordable, entry level flow chemistry system complete with everything necessary to run automated flow chemistry reactions easily and safely.
2 High pressure pumps: flow rates 0.01 to 10.0ml/min
Integrated pressure transducers: Pmax 100bar
HotCoil™ heated coil reactor station: Tmax 260°C with large visible display
Welcome to the HotCoil™, the latest addition to the Uniqsis range of flow chemistry systems and modules.
Compatible with all Uniqsis coil reactors and with an operating temperature range of ambient to +260°C, the HotCoil represents an excellent low-cost entry into flow chemistry. Simply add your own pumps to create a basic flow chemistry system. With its clear bright LED display and simple 'push-to-set' controller, the HotCoil is ideally suited to stand-alone operation. Alternatively, it can be controlled directly by the Uniqsis FlowSyn, Binary Pump Module, or the new FlowControl...
Uniqsis has published details of a mild nitration method using its FlowSyn flow chemistry system that enables short reaction times and high conversion to be achieved whilst minimising the amount of corrosive (and potentially explosive) hot nitrating mixture present in the reactor at any one time.
Nitration is an important synthetic procedure that is often difficult to control. Under continuous flow-through conditions, however, exotherms are typically well controlled and nitration can be safely performed on a large scale. Using Uniqsis’s proprietary glass static mixer/reactor chip technology - nitration can be safely performed under accelerated conditions at elevated temperature and pressure without the associated problems typically encountered in batch reactors of controlling latency periods or controlling thermal run away...
Uniqsis Ltd. has demonstrated how its proprietary glass static mixer-reactor chip technology can be used to perform highly exothermic reactions more conveniently at higher temperatures with useful throughputs under continuous flow-through conditions.
To achieve high reproducibility and facilitate scale up, it is important to control both mixing and temperature, particularly for highly exothermic or rapid mixing-dependent reactions (‘Type A’ reactions). Where the diffusional mixing provided by simple ‘T’-piece mixers is too slow to afford good control and reproducible reaction outcomes, Uniqsis has introduced a range of ingenious glass static mixer blocks ('chips') that incorporate channels with active mixing geometries to provide efficient turbulent mixing throughout the reaction vessel whilst also functioning as very efficient heat exchangers...
Uniqsis Ltd has announced a new Gas Addition Module for its FlowSyn continuous flow reactor range. The new module enables fast, controllable pre-saturation of liquid reagents with a wide range of gases thereby promoting efficient gas-dependent reactions in flow, such as carbonylation, hydrogenation, ozonolysis and direct synthesis of carboxylic acids
Mixing gas and liquids in a controllable and reliable manner has always posed a particular challenge for flow chemists, in particular the prevention of undissolved gas bubbles which have an adverse effect on the control of pressure and residence time in flow chemistry. The novel pressurised tube-in-tube design of the Gas Addition Module overcomes this problem by ensuring continuous interaction between the gas and liquid at every point along its length....
Using a Uniqsis FlowSyn™ flow reactor system - Sygnature Discovery, a leading provider of integrated drug discovery services to the pharmaceutical industry, has reported results demonstrating how the system allows them to perform traditionally hazardous chemistries in a controlled manner
For example, using the proprietary FlowSyn technology with a Uniqsis GAM IIgas-liquid reactor, laboratory scientists at Sygnature Discovery, in conjunction with Uniqsis, have developed high pressure reaction protocols that have enabled them to reproducibly perform carbonylation chemistries under continuous flow through conditions...
Uniqsis has announced a new portfolio of modular flow systems, based around its Binary Pump Module (BPM) and FlowSyn™ flow reactor technology to provide users with greater flexibility and broader synthesis capabilities
Uniqsis developed the original two-channel FlowSyn™ flow reactor system as a fully integrated ‘one box’ solution to make the emerging technology of continuous flow chemistry easily accessible to anyone with an interest in exploring and exploiting this exciting field of research. This system, which handles simple homogeneous and heterogeneous reactions at the push of a button, represents an easy, hassle-free entry into continuous flow chemistry.,,,
Available from Uniqsis Ltd. the FlowSyn Polar Bear™ is a state-of-the-art chiller unit which, in combination with FlowSyn Continuous Flow Reactor, allows you to perform and control reactions down to -88°C
The FlowSyn Polar Bear™ provides faster and more efficient cooling than conventional chiller units and is ideal for pre-cooling reagents and controlling temperature in highly exothermic reactions. The system is compatible with the FlowSyn range of reactor modules and is designed to prevent ice formation so that you can clearly observe reactions as they occur.
Uniqsis of Cambridge, UK, and WaveCraft of Uppsala, Sweden, have entered into a collaborative agreement to develop and market a new range of microwave-based flow chemistry systems that will radically improve efficiency when scaling up compound synthesis during drug development...
Flow Chemistry Specialist Uniqsis Introduces New Gas Addition Module for Continuous Flow Reactors
Aug 4, 2011Flow chemistry specialist Uniqsis Ltd is introducing a new Gas Addition Module for the Uniqsis FlowSyn and other continuous flow reactors. The new module enables fast, controllable pre-saturation of liquid reagents with a wide range of gases and so promotes efficient gas-dependent reactions in flow, such as hydrogenation, ozonolysis, carbonylation, and direct synthesis of carboxylic acids...
Cambridge Companies Collaborate in the Launch of New Products for Flow Chemistry
Jun 7, 2011Uniqsis Ltd and Cambridge Reactor Design Ltd (CRD), both based near Cambridge, England, are collaborating in the commercialisation of an advanced cooling system for continuous flow reactors used in flow chemistry. Known as the FlowSyn Polar Bear, the new system enables controlled mixing and cooling of reagents at temperatures down to -88°C...
Cambridge Reactor Design and Uniqsis announce joint marketing agreement
May 10, 2011Cambridge Reactor Design and Uniqsis are pleased to announce that they have entered into a joint marketing agreement for the Gastropod gas introduction module and the Polar Bear low temperature reactor, for flow chemistry applications...
Increasing the flow
Mar 15, 2011Uniqsis has launched the first instrument on the market for multi-kilogram flow chemistry. FlowSyn MAXI, allows users to safely perform larger-scale flow reactions, at up to 100ml/min between -90ºC and 260ºC, and at pressures up to 1400 psi.
Versatile chilled reactor for sub-zero flow chemistry
Nov 29, 2010FlowSyn ‘Cold' from Uniqsis is a stand-alone reactor module which, when coupled with the FlowSyn integrated continuous flow reactor and a recirculating chiller/heater, allows reactions to be performed at precisely controlled temperatures between -70°C and +150°C.
FlowSyn AUTO-LF
Oct 5, 2010Uniqsis (Cambridge, UK) has further enhanced the FlowSyn by launching an automated loop filling module (FlowSyn Auto-LF) that allows flow chemists to perform multiple experiments with multiple reagents automatically. With simultaneous loop filling and fraction collection this highly versatile research tool enables chemists to harness the power of flow to deliver more compounds even faster.
FlowSyn - Your Perfect Match for Flow Chemistry
Aug 11, 2010The FlowSyn Continuous Flow Reactor from Uniqsis (Cambridge, UK) now gives chemists the freedom to choose the FlowSyn system with the appropriate flow path material best suited to their particular chemistry.
Sub-Ambient Flow Chemistry
Dec 9, 2009A new interchangeable reactor tray is now available for the Uniqsis FlowSyn Continuous Flow Reactor that extends the system’s working temperature range down to -40°C.
Flow Chemistry Scale Up for Microwave Reactions
Dec 9, 2009Three new Application Notes from Uniqsis Ltd, manufacturers of the FlowSyn™ Continuous Flow Reactor, describe how the system can reproduce and scale up reactions that have been developed using small scale batch reactions in a microwave reactor.
Uniqsis has developed an extensive range of affordable ‘building block’ modules to which you can simply add your own pumps to create a flow chemistry system. Compatible with a wide range of existing hardware – Uniqsis reactor modules significantly lower the cost of setting-up a high-performance flow chemistry system. Beneficially you can invest in just the capabilities you need now while preserving the ability to expand your flow chemistry system in future without redundancy...
The FlowLab Column™ from Uniqsis is an affordable flow chemistry system designed specifically for high temperature and pressure catalysis applications. At the heart of the FlowLab Column™ is a HotCoil heated reactor module fitted with a HotColumn adapter to enable operation up to +260 °C (300 °C as an option). Developed as a high-performance alternative to conventional stirred batch reactors – the FlowLab Column™ can accommodate six stainless steel columns in individual insulated holders, each capable of operation up to 100 bar...
The new PHOTOCHIP™ high power LED photoreactor module from Uniqsis provides chemists with a benchmark tool to run photochemical reactions with highly efficient mixing and accurately controlled temperature. The PHOTOCHIP™ is an easy-to-use device - design optimised to perform photochemical reactions in the complete range of Uniqsis Glass Static Mixer (GSM) reactor blocks, also known as GSM chip reactors...
To enhance the reproducibility of flow chemistry scale-up - precise control of mixing and temperature in highly exothermic or rapid reactions in particular is essential. The expanding range of Glass Static Mixer (GSM) chip reactor blocks from Uniqsis produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent. Available in sizes from 270µl to 20 ml, the Uniqsis range of high-quality GSM chips can be used to perform reactions from -80°C to over 150°C...
Uniqsis report major growth in sales of its FlowSyn, FlowLab and modular based flow chemistry reactor systems to leading Chinese academic institutions. Most recently, local distributor - Beijing SMS has installed systems at ICCAS, Kunming University and Sichuan University. These academic institutions were interested in acquiring easy to use and maintain, high performance flow chemistry systems...
The Borealis™ from Uniqsis brings flow photochemistry within the budget of almost any laboratory. The Borealis™ sets a new benchmark for safe high yield photochemical flow synthesis. Equipped with a safety interlock, to prevent accidental exposure to high intensity light, the LED lamps (available in a range of fixed wavelengths - 370, 410, 440, 460 and 520nm), are powered by a programable power supply that automatically detects the wavelength of the Borealis™ LED module and adjusts the output characteristics accordingly..
At the forefront of flow reactor design, FlowSyn™ from Uniqsis sets the standard for automated optimisation of heterogeneous catalysis reactions. The use of solid supported reagents, catalysts and scavengers in flow reactor systems offers significant benefits over conventional batch heterogeneous catalysis techniques. Their use often avoids the need for downstream product purification and leads to enhanced reaction rates and higher overall efficiency due to the large excess of catalyst...
For synthesis labs looking to undertake small scale photochemical reactions – Uniqsis has introduced Solstice™ – a compact, temperature-controlled batch photoreactor that combines affordability, high-performance and flexibility. Solstice™ is the ideal photochemical synthesis tool for reactions involving solid materials (such as catalysis), optimisation of reaction conditions and production of small compound arrays...
The Uniqsis FlowLab Plus™ is a versatile flow chemistry system with a wide choice of high-performance modules to match your application needs. Designed around the proven Binary Pump™ dual channel reagent delivery system, the FlowLab Plus™ can be configured to run both manual and automated flow chemistry reactions. This versatile system may be configured with any combination of up to 4 individual reactor modules....
Uniqsis reports that demand for its Flow-UV inline UV-Visible spectrophotometer for biological, biotech, drug discovery and industrial applications grew to record levels during 2022. Compact in design, the Flow-UV from Uniqsis sets a benchmark for real time monitoring of continuous flow and batch applications. Unlike many UV-visible spectrophotometers the high-resolution Flow-UV CCD array detector does not require calibration or routine servicing...
Used in conjunction with an external thermoregulation circulator, the Cold Coil II™ flow reactor module from Uniqsis can maintain stable temperatures between -78°C and +150°C for extended periods of time. Proven to provide a flexible, entry-level solution for low temperature flow chemistry applications the Cold Coil II™ includes a glass cover to eliminate convective effects within fume cupboards...
Uniqsis offers a range of reactor modules designed to enable labs, with a limited budget, to build flow chemistry systems without compromising performance considerations. The Cold Coil II™ Flow Reactor Module is designed to provide a flexible, entry-level solution for low temperature flow chemistry applications. Used in conjunction with an external thermoregulation circulator the Cold Coil II™ can maintain stable temperatures between -78°C and +150°C for extended periods of time....
The Uniqsis PhotoSyn™ LED photoreactor eliminates problems associated with traditional batch methods enabling synthetic chemists to routinely scale-up their photochemistry reactions from milligrams to several kilograms / day. The PhotoSyn™ is designed to provide scientists with a high-power LED light source for continuous flow applications...
The PhotoSyn™ high power LED photoreactor, from Uniqsis, eliminates problems associated with traditional batch methods enabling synthetic chemists to routinely scale-up their photochemistry reactions from milligrams to several kilograms / day. The PhotoSyn™ is designed to provide scientists with a high-power LED light source for continuous flow applications...
Researchers at the University of Pretoria (South Africa) have developed a general platform for performing closed loop reaction optimisation by integrating a Uniqsis FlowSyn Maxi continuous flow reactor with an analytical HPLC. In the reported work the FlowSyn Maxi was controlled over ethernet using an open-source Node-Red dashboard running on a Raspberry Pi linked to the single objective optimisation algorithm...
Uniqsis has launched ColdChip™ - a new versatile mixer/reactor module enabling researchers to experiment with different chemistries particularly exothermic reactions that need to be safely run in a cooled environment with highly efficient mixing. Compact in design, and requiring no input power, the ColdChip™ is optimised for use with the Uniqsis FlowSyn and FlowLab range of flow reactors as well as standalone pumps....
The Uniqsis Polar Bear Plus Flow™ is a compact, state of the art temperature control module, that can be used as a standalone unit or integrated with a flow reactor, for both heated and cooled flow chemistry applications. Utilising highly efficient, compressor-based cooling and heating technology the Polar Bear Plus Flow™ can precisely and reliably maintain reactor temperatures anywhere between -40?C and +150?C. The module is easy to use and is completely self-contained, requiring only an electricity supply for operation...
The FlowSyn Maxi™ from Uniqsis is a high throughput flow reactor for process chemists looking to optimise reaction conditions before scaling-up synthetic production to multiple kilograms per day. Combining the benefits of proven FlowSyn technology with the capability to run at high flow rates (up to 100 ml/min) in a compact benchtop design - the FlowSyn Maxi™ sets a new standard for higher throughput applications...
The FlowLab Column from Uniqsis is a continuous flow chemistry system developed as an affordable high-performance replacement for conventional stirred batch reactors often used for heterogeneously catalysed liquid phase reactions. Designed to provide highly efficient mixing and excellent control over reaction parameters, the FlowLab Column provides intimate contact between a large excess of catalyst and a small quantity of reagent at any point in time resulting in increased reaction rates and higher yields....
Borealis™ from Uniqsis is a new high intensity LED lamp unit, available in a range of fixed wavelengths (370, 410, 440, 460 and 520nm), that converts their Cold Coil™ standalone reactor module into a flow reactor for photochemical applications. Both the Borealis™ LED lamp and the Cold Coil™ reactor modules require liquid cooling from either a piped water supply or a closed loop recirculator...
To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Uniqsis expanding range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent...
Specialists in flow chemistry - Uniqsis has introduced the Photochemistry LED Illuminator – a new tool to accelerate reaction optimization and batch scale-up of photochemical reactions. The new illumination system incorporates LED arrays operating at 6 different wavelengths from 365 – 525nm. The LEDs are mounted on cassettes for easy interchangeability, in industry-standard 24 or 48 well configurations....
Uniqsis makes flow chemistry accessible to everyone, while at the same time catering for multi-step and automated reactions sequences, through the availability of an expanding suite of affordable 'plug and play' reactor modules. Compatible with all Uniqsis coil reactors and with an operating temperature range of ambient to +300°C, the HotCoil™ reactor heating module represents a cost-effective entry solution into flow chemistry....
The Uniqsis range of Glass Static Mixer (GSM) chip reactor blocks produce an efficient, turbulent mixed reagent stream for flow chemistry reactions that is not diffusion dependent. To achieve highly reproducible flow chemistry scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Now available in sizes from 270µl to 20 ml, the recently expanded range of GSM chips from Uniqsis can be used to perform reactions from -80°C to over 150°C...
Uniqsis offers an extensive range of individual flow chemistry modules that can be used on any flow chemistry system.These convenient, high quality, plug-and-play modules have been designed to enable researchers to configure a flow chemistry system precisely to meet their needs. Uniqsis flow chemistry modules include a comprehensive range of...
Uniqsis reports on two major orders for its FlowSyn™ flow chemistry systems from organisations involved with the South African Pharmaceutical Industry. In the pharmaceutical sector, industry growth in the emerging world is rapidly outpacing mature markets like Europe and the US. Although at present the pharma industries across Africa account for just 2% of the global medicines market....
Uniqsis reports on how its Flow-UV™ inline UV-Visible spectrometer sets a new benchmark for real-time dispersion and nanoparticle distribution and agglomeration experiments. Designed for use with almost any commercially available flow chemistry system, Flow-UV™ allows dispersion experiments to be monitored in real time so that product collection can be controlled...
The renowned Innovative Technology Centre (ITC) at the University of Cambridge, UK has used a Uniqsis PhotoSyn flow photoreactor to efficiently scale-up a radical mediated boronic acid coupling under photoredox conditions using a novel organic acridium-based photocatalyst. The acridium-based organic photocatalyst, developed by the University of Cambridge, is demonstrated to be an efficient replacement for iridium-based photocatalysts used to oxidise boronic acid derivatives by a single electron radical coupling process....
Uniqsis has introduced the Polar Bear Plus GSM™ - a versatile heating and cooling reactor module for flow chemistry applications using Glass Static Mixers / Reactor Chips (GSMs). To achieve high reproducibility and facilitate scale-up the control of mixing and temperature is essential, particularly for highly exothermic or fast, mixing-dependent reactions. Uniqsis glass static mixer / reactor chips produce an efficient, turbulent mixed reagent stream...
Uniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. FlowLab Plus™ is a versatile flow chemistry system built around the Uniqsis Binary Pump™ dual channel reagent delivery system. The system is configured to run both manual and automated flow chemistry reactions....
Uniqsis introduces the FlowLab Plus™ for process research chemists looking for a flow chemistry system combining top performance with true operational flexibility. 
Uniqsis reports how the Institute of Physics at the University of Tartu (Estonia) has selected a FlowSyn™ continuous flow reactor with Flow-UV™ detector to assist them in development of novel nanomaterials for use in next generation applications. The material science research group of Dr Aile Tamm evaluated different technological approaches to synthesise nanomaterials before investing in the Uniqsis FlowSyn system...
The Uniqsis PhotoSyn™ is a new high-power LED light unit enabling scalable flow photochemistry reactions yielding from milligrams to 100’s of grams per day. By eliminating the control, scale-up and safety problems associated with traditional batch photochemistry – the Uniqsis PhotoSyn™ enables synthetic chemists to routinely take full advantage of the many benefits offered by photochemistry...
Uniqsis announces HotChip™ - a new standalone heater module that provides precise temperature control of flow chemistry glass static mixer (GSM) chip reactors. The Uniqsis range of chemically-resistant borosilicate glass chip reactor blocks can be used as static mixers to ensure effective mixing before a coil reactor or to perform fast exothermic experiments such as nitration’s or bromination’s where reaction times are often less than 1 minute...
Uniqsis reports how chemists at the School of Pharmacy, University College London (UK) have been using a FlowSyn™ continuous flow reactor system.
Pyrazoles are an important and well represented chemotype in drug discovery displaying wide ranging biological actions that include analgesic, anti-inflammatory, antipyretic, tranquilizing, muscle relaxing, anticonvulsant, antidiabetic and antibacterial activities....
Catalysts can be divided into two main types - heterogeneous and homogeneous. In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....
Catalysts can be divided into two main types - heterogeneous and homogeneous. In a heterogeneous reaction, the catalyst is in a different phase from the reactants. This facilitates both separation of the reaction product from the catalyst and re-use of the catalyst.....
Following a trial of the FlowSyn™ system – Arcinova could justify their investment based upon rapid synthetic method development and the considerable cost and time savings demonstrated versus using large scale reactor vessels for the selected process. Dr. Samuel Bourne, Continuous Manufacturing Lead at Arcinova commented...
Olefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility....
Olefin metathesis is an important reaction that provides a useful synthetic route to highly functionalized molecules such as drug precursors or polymers. Although this reaction is highly efficient in batch, scaling-up usually results in poor reproducibility. While several research groups have reported the development of olefin metathesis in continuous flow, most of them have focused on the use of a heterogeneous catalyst....
Built around the same high quality components as used in the widely acclaimed Uniqsis FlowSyn™ system, both the FlowLab™ and FlowLab Cold™ offer uncompromised performance at an entry-level price. The FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control computer...
Designed for use with almost any commercial flow chemistry system - the compact Flow-UV™ detector (18 x18 x 17cm) fits conveniently into even crowded fume cupboards. Using the UV-visible absorbance data from a Flow-UV™ detector allows dispersion experiments to be monitored in real time and enables product collection to be controlled according to the onset and decline of steady state conditions....
The FlowLab™ system comprises two high pressure pumps, a HotCoil™ coil reactor station and FlowLab™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be controlled remotely by Wi-Fi, allowing the control computer to be conveniently operated outside the fume hood....
The system comprises two high pressure pumps, aHotCoil™ coil reactor station and FlowStart™ system control. The computer, pumps and HotCoil™ are connected over a LAN using an Ethernet hub. In this way, the system can be operated by Wi-Fi allowing the control computer to be conveniently operated outside the fume hood. The FlowStart™ application provides control of the system via a step-through interface that is straightforward...
Compatible with all Uniqsis coil reactors and with an operating temperature range of ambient to +260°C, the HotCoil represents an excellent low-cost entry into flow chemistry. Simply add your own pumps to create a basic flow chemistry system. With its clear bright LED display and simple 'push-to-set' controller, the HotCoil is ideally suited to stand-alone operation. Alternatively, it can be controlled directly by the Uniqsis FlowSyn, Binary Pump Module, or the new FlowControl...
Mixing gas and liquids in a controllable and reliable manner has always posed a particular challenge for flow chemists, in particular the prevention of undissolved gas bubbles which have an adverse effect on the control of pressure and residence time in flow chemistry. The novel pressurised tube-in-tube design of the Gas Addition Module overcomes this problem by ensuring continuous interaction between the gas and liquid at every point along its length....
For example, using the proprietary FlowSyn technology with a Uniqsis GAM IIgas-liquid reactor, laboratory scientists at Sygnature Discovery, in conjunction with Uniqsis, have developed high pressure reaction protocols that have enabled them to reproducibly perform carbonylation chemistries under continuous flow through conditions...
The FlowSyn Polar Bear™ provides faster and more efficient cooling than conventional chiller units and is ideal for pre-cooling reagents and controlling temperature in highly exothermic reactions. The system is compatible with the FlowSyn range of reactor modules and is designed to prevent ice formation so that you can clearly observe reactions as they occur.
Uniqsis of Cambridge, UK, and WaveCraft of Uppsala, Sweden, have entered into a collaborative agreement to develop and market a new range of microwave-based flow chemistry systems that will radically improve efficiency when scaling up compound synthesis during drug development...
Flow chemistry specialist Uniqsis Ltd is introducing a new Gas Addition Module for the Uniqsis FlowSyn and other continuous flow reactors. The new module enables fast, controllable pre-saturation of liquid reagents with a wide range of gases and so promotes efficient gas-dependent reactions in flow, such as hydrogenation, ozonolysis, carbonylation, and direct synthesis of carboxylic acids...
Uniqsis Ltd and Cambridge Reactor Design Ltd (CRD), both based near Cambridge, England, are collaborating in the commercialisation of an advanced cooling system for continuous flow reactors used in flow chemistry. Known as the FlowSyn Polar Bear, the new system enables controlled mixing and cooling of reagents at temperatures down to -88°C...
Cambridge Reactor Design and Uniqsis are pleased to announce that they have entered into a joint marketing agreement for the Gastropod gas introduction module and the Polar Bear low temperature reactor, for flow chemistry applications...
Uniqsis has launched the first instrument on the market for multi-kilogram flow chemistry. FlowSyn MAXI, allows users to safely perform larger-scale flow reactions, at up to 100ml/min between -90ºC and 260ºC, and at pressures up to 1400 psi.
FlowSyn ‘Cold' from Uniqsis is a stand-alone reactor module which, when coupled with the FlowSyn integrated continuous flow reactor and a recirculating chiller/heater, allows reactions to be performed at precisely controlled temperatures between -70°C and +150°C.
Uniqsis (Cambridge, UK) has further enhanced the FlowSyn by launching an automated loop filling module (FlowSyn Auto-LF) that allows flow chemists to perform multiple experiments with multiple reagents automatically. With simultaneous loop filling and fraction collection this highly versatile research tool enables chemists to harness the power of flow to deliver more compounds even faster.