Market leader in temperature and environmental-controlled microscopy, Linkam Scientific Instruments, presented its cryobiology portfolio including the CMS196V4 stage and Modular Imaging Platform at this year’s CryOZ 2025.

Linkam Scientific Instruments, represented by its Australian cryo-products distribution partner Hin Sci, is showcasing its range of cryogenic temperature systems, including its leading CMS196V4 cryo-CLEM stage at this year’s CryOZ conference.

Linkam’s specialist CMS196V4 stage for cryo-correlative light and electron microscopy (CLEM), developed together with Leiden University Medical Centre (LUMC), was shown on the booth. The system uses liquid nitrogen cooling, allowing researchers to investigate samples at cryogenic temperatures down to < -195 °C by maintaining vitrification of samples and delivering contamination-free imaging. New features, including a continuous sample chamber fill mechanism, cordless heated lid and an interchangeable cryo-bridge, have dramatically improved stability performance and ease-of-use.

Linkam are also presented its Modular Imaging Platform, whose modular configuration significantly improves sample access and supports multiple microscopy techniques.

At the event, Linkam specialists also delivered two poster presentations introducing one of the company’s latest developments, the robotic plunge-freezing CryoGenium system, and presenting new and improved features of its CMS196V4 cryo-CLEM stage.

The CryoGenium is an automated blotting-free cryo-plunger for single-particle and cell-based workflows. Breaking away from conventional blotting-based techniques, the CryoGenium uses a novel suction approach to control sample thickness to optimise process stability and repeatability, and allows direct optical access to the sample for real-time monitoring. The automation of the platform significantly increases reproducibility, speed and throughput, and eliminates the potential risk of contamination associated with manual sample handling.

Clara Ko, Sales and Marketing Director at Linkam, comments: “Cryo-electron microscopy is fast becoming a key tool in biomedical research and drug development. We’re continually updating and expanding our cryobiology portfolio to meet increased demand and are proud of the role Linkam stages play in driving advances in research to support new scientific discoveries.”

About Linkam Scientific Instruments 

Linkam develops and manufactures a broad range of temperature and environmental control stages for both OEMs and end users. From high to cryo- temperatures as well as humidity, electrical connections, gas purging, vacuum and pressure, for enhanced sample analysis. Linkam stages are used with light microscopes and a wide range of analytical techniques including Raman, FTIR, SAXS-WAXS and many more to visualise and characterise the properties of materials. Linkam stages are found in thousands of laboratories worldwide with the most successful microscope heating stage, the THMS600, selling over 6,000 units alone. Linkam is the market leader in temperature-controlled microscopy. 

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