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Thermo Fisher Scientific Introduces New Low-Flow HPLC Columns for Proteomic Research

publication date: Apr 4, 2023
author/source: Thermo Fisher Scientific


Thermo Scientific µPAC Neo HPLC Columns Deliver Improved Separation Performance and Stability for Biologically Complex Samples

Thermo Fisher Scientific is providing proteomics and biopharmaceutical research laboratories with a new line of low-flow HPLC columns that improve separation performance and stability of biologically complex samples.

Using a unique micro-pillar separation structure, the Thermo Scientific µPAC Neo HPLC Columns enable researchers to investigate proteomics samples in greater detail, from accurate identification of peptides to determination of protein quantities, discovery of disease biomarkers and post-translational modifications.

The newest addition to the portfolio is the µPAC Neo low-load trapping column which is ideally suited for the smallest samples sizes in single-cell proteomics separations and features built-in nanoViper connections to the Vanquish Neo UHPLC systems for ease of use and reduced risk of errors. Users of all µPAC Neo columns benefit from excellent column reproducibility, allowing for more reliable data interpretation and confidence in their results.


The full µPAC Neo column portfolio offers

  • 50 cm µPAC Neo column for routine proteomics
  • 110 cm µPAC Neo column for comprehensive proteomics
  • 50 cm µPAC Neo low-load column for single-cell proteomics
  • µPAC Neo low-load trapping column to support single-cell proteomics separations


µPAC Neo columns are manufactured by micromachined etching of silicon wafers, resulting in highly reproducible separation paths. For proteomics researchers, this provides higher column-to-column consistency and longer column lifetimes compared to packed-bed columns, allowing for more robust development and validation of methods and easier study of larger sample batches.


Key Applications

  • Proteomics and biopharmaceutical research



  • Unique column technology that delivers optimal sample coverage and improved protein identification
  • Extra-high resolution separations of highest complexity samples
  • Excellent column reproducibility for more reliable data interpretation
  • Long column lifetimes to reduce the number of column exchanges and increase system uptime



About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue over $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.


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