Follow us...

 

Search News Archives

Channels

News

 

 

View Channel

Laboratory Products

 

 

View Channel

Special Offers and Promotions

 

Microscopy | Image Analysis

 

 

View Channel

Separation Science

 

 

View Channel

Coronavirus (COVID-19)

 

 

View Channel

Research & Case Studies

 

 

View Channel

Brochures & Literature

 

 

View Channel

 

Conferences | Events

New Vacuum Nucleation Induction Method in the Freeze-Drying Process Suitable for any type of Freeze-Dryer

publication date: Oct 4, 2018
 | 
author/source: Telstar

Telstar Lyonuc


The method reduces the duration of the primary drying cycle and ensures the homogenization of the batches of vials. Particularly effective in long duration freeze-drying cycles

A new vacuum nucleation induction method in the freeze-drying process suitable for  any type of freeze-dryer without modifying its main elements or adding gases or external substances has been developed. After years of research, Telstar’s innovation department has unveiled the solution for effectively inducing the start of nucleation in the freeze-drying process which, using prescriptions adapted to the specifications of each product, enables the pharmaceutical industry to run the freeze-drying process of product batches more efficiently, quickly, productively and uniformly. This new method –Telstar Lyonuc- will be presented and demonstrated at CPhI (Madrid 2018, 9-11 October).

The vacuum-induced nucleation system produces a change in the solid structure of the solution and manages to homogenise the moment when the freezing starts so that all the vials nucleate at the same time in a few seconds, instead of taking 30-45 minutes which is how long the spontaneous nucleation process can last. This method based on controlling the temperature and pressure and inducing the start of the freezing phase, also ensures the uniformity and homogenisation of the vials in all the batches, respecting the product’s physiochemical properties.

The new vacuum nucleation induction method can be adapted to any type, model or brand of freeze-dryer. This is possible because unlike other methods being studied on the market, where it is necessary to add gases external to the process or use decompression processes requiring special equipment, this new method only requires measuring and controlling the temperature, vacuum and time parameters and it uses the actual tools of a freeze-drying prescription. This new method is particularly indicated for long duration freeze-drying cycles, where the benefit of reducing the drying time is much greater.

As well as improving the theoretical vacuum nucleation induction process developed by Kramer and Liu at the beginning of this century, the research developed by Telstar has delved into the aesthetic behaviour of the freeze-dried solution which is usually altered during the vacuum nucleation induction process.


more from Telstar



If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners