Merck Millipore, has launched Simplicon™ RNA Reprogramming Technology, which uses synthetic self-replicating RNA to create large numbers of human induced pluripotent stem cells (iPSCs) using a single transfection step.

This efficient reprogramming of somatic cells is accomplished without viral intermediates or host genome integration, offering a more defined and safer system for iPSC generation. "For stem cell researchers using iPSCs to study disease, differentiation and regenerative medicine, there's a real need for a reprogramming method that's as efficient as virus-based techniques yet as safe as non-viral methods," said Christophe Couturier, Head of Bioscience, Merck Millipore...

The project will be funded EUR 900K (USD 1.25 M) in total by the Belgian Walloon region and the Massachusetts Life Sciences Center (MLSC)

Promethera(R) Biosciences, a company that develops innovative therapies for the treatment of liver diseases, today announces a collaboration with EMD Millipore to develop an improved ready-to-use microfluidic perfusion liver assay. This new product is designed to perform more robust studies in pre-clinical toxicity and drug metabolism. Early availability of reliable human liver-based assays is critical to the pharmaceutical industry when deciding to bring a lead compound in clinical phase development....

Merck Millipore, the Life Science division of Merck KGaA, today announced that it will hold its 2014 Predictable Protein Performance Virtual Conference on March 26 and 27, 2014. 

The conference theme, "Predictable Protein Performance," will bring industry experts from around the world to discuss different aspects of this important topic. Conference speakers will explore why analyzing protein expression, structure, and function is key to any biological discovery and also outline strategies that researchers can take to ensure that the protein in their tubes accurately represents its native form, in its physiological context. Virtual Conference participants will learn how to maximize the information that can be obtained from each precious protein sample, no matter how complex or challenging it might be...

Merck Millipore, the Life Science division of Merck, today announced the expansion of its biomarker testing service capabilities with the launch of flow cytometry services at its North America facility.

Merck Millipore offers a comprehensive portfolio of reliable and reproducible HPLC separation tools even for the most challenging analysis problems in research and development, quality control, environmental, clinical and biochemical analysis.

Merck Millipore highlights its new ZIC^®-HILIC technology, a zwitterionic HILIC phase for LC-MS separation of polar compounds.

Merck Millipore offers a comprehensive portfolio of reliable and reproducible LC-MS separation tools even for the most challenging analysis problems in research and development, quality control, environmental, clinical and biochemical analysis.Merck Millipore will host a breakfast seminar on HILIC and analytical chromatography. Presentations include a discussion on how separation selectivity differs between HILIC columns; models will be shown to explain how to select columns....

In this new application note, Millipore describes how a Novel RNA detection reagent enables gene expression analysis in living cells.

This technology allows for carrier- free cellular endocytosis of the reagent, followed by detection and relative quantitative analysis of RNA levels. Because the reagent leaves the cell after the detection event, the same sample can be used for any downstream analysis, meaning you can assess multiple biomarkers or downstream functionalities in the same cells. Additionally, this reagent requires no upfront sample preparation, has no toxic effects on cellular fate and no known nonspecific, off-target effects....

Merck Millipore, the Life Science division of Merck, has announced availability of the MILLIPLEX^® map Human Stem Cell Pluripotency Magnetic Bead Kits, which enable the analysis of many different pluripotency biomarkers in a single measurement.

Merck Millipore, the Life Science division of Merck, has introduced Amicon® Pro Purification System for Protein Purification

This centrifugal device streamlines the affinity purification workflow and minimizes protein loss. Users experience consistent, accurate sample preparation, resulting in more reliable recovery, uncompromised purity and easier data generation.

• Centrifugal device streamlines the affinity purification workflow and minimizes protein loss
• Combines the bind, wash, elute, buffer exchange and concentration steps into one device
• Supports additional applications including depletion of abundant proteins, protein enrichment and clean-up of antibody labeling reactions

Merck Millipore, the Life Science division of Merck, today announced the publication of a white paper, "Effective In Vitro Bioanalytical Assays for Comparing Pharmacodynamics of Biosimilar Monoclonal Antibodies",  which describes both regulatory and technical aspects of comparability studies for the development of biosimilars

• Describes novel ligand-binding assays developed to streamline evaluation of biosimilars
• Details use of flow cytometry and surface plasmon resonance to quantify binding of therapeutic monoclonal antibodies to molecules mediating cytotoxicity
• Assays provide valuable preclinical data about drug properties and their physiological interactions without the need for animal experiments

Merck Millipore's Discovery and Development Solutions business, part of the Life Science division of Merck, today announced it will now offer genomic biomarker services to aid drug companies in targeting patient sub-groups for improved clinical outcomes, understanding drug safety and efficacy, and characterizing tumors

• Genetic and epigenetic technologies added to established CRO services for biomarker development, validation and testing
• Consolidated protein, genomic and cell-based bioanalysis services enable multiple biomarker analysis for better pipeline decisions
• Genomic biomarkers advance "Precision Medicine," helping identify patients most likely to respond to a drug or experience side effects

Merck Millipore, the life science division of Merck, today released MILLIPLEX® Analyst 5.1 for analysis and interpretation of Luminex® bead-based assay results

• Enables more rapid and efficient management, tracking, and analysis of multiplex assays
• Provides superior quality of fit, autofit, and potency calculation compared to other Luminex software packages
• Relational database functionality enables analysis of multiple files from different experiments

Merck Millipore, the life science division of Merck, today announced that Merck Millipore has entered into an agreement with an academic consortium funded by the NIH, to distribute more than 140 peer-validated neuroscience-specific monoclonal antibodies through its worldwide network

• Adds more than 140 peer-validated neuroscience-specific monoclonal antibodies to portfolio
• Includes antibodies for neurotransmitters and neurodegeneration
• All antibodies independently peer-reviewed and validated

Merck Millipore, the life science division of Merck,has announced the launch of Vegetable Contact Agar + LTHTh - ICRplus, a ready-to-use plate ideal for environmental monitoring of isolators and clean rooms

• Ready-to-use plate determines a surface's microbial count
• Minimizes the risk of TSE/BSE contamination during environmental monitoring
• Provides superior growth promoting properties and neutralization of disinfectants

• Enables NGS library preparation in under two hours, less hands-on time than similar kits
• Delivers maximum library yields from less input DNA with minimal bias for better results
• Provides higher genome coverage and more matched reads
• Processes samples of virtually any biological liquid, whole tissue and tissue sections

• Mobius® CellReady bioreactor provides a disposable, single-use platform for industrial production of stem cells
• Facilitates consistent, reproducible large scale expansion of adult stem cells