Project will help to develop novel medicines to treat aggressive forms of blood cancer
A collaboration between the University of Leicester and global pharmaceutical company GlaxoSmithKline (GSK) has been established to discover and develop novel medicines to treat aggressive forms of blood cancer. High grade non-Hodgkin’s lymphoma is one of the most common forms of blood cancer, with more than 5,000 new cases reported each year in the UK. Professor Simon Wagner...
Have you seen the latest agenda for our 2nd Annual Next Generation Sequencing and Single Cell Analysis USA Congress?
Our unique programme features academics at the forefront of sequencing research, insights from biotech and pharmaceutical organizations and presentations from researchers working in clinical and diagnostic settings. With over 60 speakers over 2 days covering NGS therapeutic applications in research and in the clinic, data and computational biology, the latest in single cell technologies and techniques and...
The Michael Smith Laboratories at the University of British Columbia, Canada, is leading the way in the use of Raman spectroscopy as a tool for monitoring biochemical changes and inter-donor variability in stored red blood cell (RBC) units1,2.
The research group of Professors Michael Blades and Robin Turner recently published this work in the Analyst. For this work the group collaborated with the Canadian Blood Services, using Raman microspectroscopy (RMS) to investigate the chemical changes that occur in red blood cells (RBC's), during storage in bags, which could eventually be used as a quality check prior to transfusion....
Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....
INTEGRA has prepared an explanatory application guide that demonstrates the benefits of its electronic adjustable tip spacing VOYAGER II pipette range in transferring liquid samples between different labware formats.
Many laboratory applications require liquid transfers between various labware formats. Due to varying requirements in their sample processing, different labware vessels are typically used for sample storage, processing and analysis tasks. Traditional multichannel pipettes were not designed to accommodate the wide variety of labware formats used today because their tip to tip spacing is optimized for use with standard 96-well microplates....
OGT workshop at ESHG highlighted the impact of exon-level CNV analysis on accurate detection of genetic disorders
Oxford Gene Technology (OGT), The Molecular Genetics Company, held an exclusive workshop exploring the power of exon-focused microarrays in enhancing genetic syndrome research at the recent European Human Genetics Conference (ESHG). Three expert clinical researchers from across the globe shared their knowledge of enhanced CNV detection with OGT’s CytoSure™ Constitutional v3 array, helping viewers...
Cambridge Consultants works with WaveGuide on world’s first portable NMR scanner
Product design and development firm Cambridge Consultants is working with medical device start-up WaveGuide Corporation on a world first to tackle the global problem of tuberculosis (TB), as well as other diseases. The two companies are developing a unique portable nuclear magnetic resonance (NMR) scanner to provide fast, low-cost, point-of-care (POC) testing for disease in developing countries...
SP Scientific is now able to offer a one-source solution for a complete range of pharmaceutical processing equipment.
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands advantageously position SP Scientific with capability to manufacture complete aseptic vial processing lines....
John McAslan + Partners has won an international competition to design the new GeoSciences Building for the University of Edinburgh.
The University’s School is ranked in the top 16 such faculties worldwide and is the largest community of GeoScientists in the UK, home to 400 academics and research students. A reinterpretation of the typical laboratory layout will achieve transparency throughout the building, visually connecting write-up areas, laboratories, group rooms and offices...
SP Scientific announces the introduction of the LyoModelling Calculator (LMC) - a powerful new software utility that enables those developing freeze drying cycles to calculate the time required for primary drying and the maximum product temperature based on user data input.
This free software resource is available on the SP Scientific website**. Users obtain a starting point for primary drying duration and the maximum product temperature at the sublimation interface using pertinent information, such as shelf temperature and chamber pressure, from which an optimized freeze-drying cycle can be developed. The LMC is based on the steady-state heat and mass transfer model of primary drying developed by...
Merger forms ReproCELL Europe Ltd, led by Dr David Bunton
The Japanese regenerative medicine company ReproCELL Inc., has announced that two of its Group companies, Biopta and Reinnervate, will merge to form a new company, ReproCELL Europe Ltd. The merger is aimed at strengthening ReproCELL’s pharmaceutical industry-targeted drug discovery services and products through the integration of Biopta’s human tissue services with Reinnervate’s stem cell and 3D cell...
New worldwide, exclusive license agreement provides broad access to institut Pasteur's virus vector technology - Zika vaccine development progressing with high priority.
Themis successfully extended its existing license agreement with Institut Pasteur, France, which grants the company a broad access to a well-established virus vaccine vector technology. The safety and tolerability profile of the vector was already proven in a Phase I trial when the two partners used the technology platform for the development of a first in class Chikungunya vaccine...
In-depth profiling of IgG glycosylation coupled with ADCC assays enables generation of robust biosimilar comparability data
Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, announced the launched of a new Released N-Glycan Assay for the in-depth profiling of IgG glycosylation. This new physico-chemical assay, developed by SSB’s subsidiary BioOutsource and offered in combination with its unique Antibody Dependent Cell Cytotoxicity (ADCC) assay platform, combines data on the molecular structure...
Today Lonza announced the release of a new e-Learning Module for its QC Insider™ Toolbox, “Overcoming Interference,” which covers the causes of interference in the Bacterial Endotoxins Test (BET) and provides the user with solutions to help ensure compliance.
Being able to overcome the inhibitory or enhancing properties of a sample is required by the BET monograph, the validation of which forms part of the test for the final product release of injectable drugs and medical devices. Many of the pharmaceutical products that are either in use or being developed today have characteristics that cause them to interfere with the BET....
Merck has entered into an agreement with PCAS S.A. to expand Merck’s excipients portfolio. Under the agreement, Merck will be the exclusive, global distributor of the Expansorb® line of biocompatible and biodegradable polymers.
The portfolio will include 38 polymers for sustained release of small molecule and selected peptide injectables, allowing customers to optimize and precisely control release kinetics of final drug products. The ability to better control and sustain the release of drugs allows for delivery via reduced numbers of injections with the same therapeutic efficacy...
ISG has been awarded a £21 million technical fit out project by HSL (Health Services Laboratories) to create its new London core laboratory; a facility that will include state-of-the-art pathology laboratories serving the London health community, as well as HSL’s corporate offices.
HSL is a joint venture between The Doctors Laboratory (TDL), University College London Hospitals NHS Foundation Trust, and the Royal Free London NHS Foundation Trust. The new 133,000 sq ft laboratory in the ‘Halo’ building at One Mabledon Place, in the epicentre of the emerging biosciences corridor in Kings Cross, will see the organisation consolidate existing disparate pathology facilities from North Central London into what will become one of the largest pathology laboratories in Europe.
Avacta Group plc and Glythera Limited announce that they have established a collaboration to evaluate the use of Glythera’s PermaLink™ conjugation chemistry in combination with Avacta’s Affimer technology with the aim of developing a new class of highly targeted bio-therapeutics as a superior alternative to the established class of antibody drug conjugates (ADCs).
ADCs use an antibody to which a toxin/chemotherapy payload is chemically attached for targeted delivery to a tumour. Over 50 ADCs are currently in clinical development; of these, approximately a quarter are in Phase II or Phase III. The market is estimated to be worth around $1bn today from two approved compounds and is expected to be worth $10bn annually by 2024.
A celebratory topping-out ceremony has taken place for the new University of Glasgow £16m Imaging Centre of Excellence (ICE) building on the grounds of the Queen Elizabeth University Hospital.
This ground-breaking new centre, supported by the NHS and funded by the UK Government and the Medical Research Council (MRC) as part of the Glasgow City Region City Deal, will provide world-leading clinical research facilities and provide a hub for academic, scientific and NHS clinical expertise into brain imaging in diseases such as stroke, dementia and brain tumours....
A new streamlined approach to genetic testing for women with ovarian cancer provides testing rapidly and affordably, allowing many more patients to benefit from personalised cancer management and their relatives to benefit from cancer prevention strategies.
The new approach offers cancer patients the opportunity to get gene testing at one of their routine cancer clinic appointments instead of having to be referred to a separate genetic testing clinic. As well as offering a more streamlined patient journey, the pathway is less resource intensive for health systems and could save the NHS millions of pounds per year, if implemented nationally....
The Postnova TF2000 is an advanced thermal field flow fractionation (TF3) system that provides a highly efficient method of separating and characterising complex polymer samples such as natural or synthetic rubbers, starches and paints from approximately 10 kDa up to 100 MDa and more in organic and aqueous solvents.
The TF2000 uses a temperature gradient as the driving force for its separation of polymers and particles. Molecules affected by the thermal gradient undergo diffusion which enables separation by both their molar mass and chemical composition. This unique feature allows the separation of different materials having the same molar mass....
ELRIG (European Laboratory Research & Innovation Group) has announced its 10th Anniversary Drug Discovery meeting, which this year will take place at ACC in Liverpool, UK, located in the heart of the city beside the historic Albert Docks, from 13th-14th October 2016. ELRIG Drug Discovery is the premier meeting place in Europe for scientists from industry, biotech and academia engaged in pre-clinical drug discovery...
Insterprep instantly soluble, pre-weighed media range ensures fast and accurate sample preparation
Seward Ltd, manufacturers of the renowned Stomacher® blender and creators of the Insterprep® range of instantly soluble sterile media, has teamed up with Scientific Laboratory Supplies (SLS) as their primary distribution partner for Insterprep in the UK. Insterprep is a new range of pre-weighed, sterile, granulated media available in Stomacher® bags or sachets. Designed to speed up and simplify sample preparation for...
A collaboration between the University of Leicester and global pharmaceutical company GlaxoSmithKline (GSK) has been established to discover and develop novel medicines to treat aggressive forms of blood cancer. High grade non-Hodgkin’s lymphoma is one of the most common forms of blood cancer, with more than 5,000 new cases reported each year in the UK. Professor Simon Wagner...
Our unique programme features academics at the forefront of sequencing research, insights from biotech and pharmaceutical organizations and presentations from researchers working in clinical and diagnostic settings. With over 60 speakers over 2 days covering NGS therapeutic applications in research and in the clinic, data and computational biology, the latest in single cell technologies and techniques and...
The research group of Professors Michael Blades and Robin Turner recently published this work in the Analyst. For this work the group collaborated with the Canadian Blood Services, using Raman microspectroscopy (RMS) to investigate the chemical changes that occur in red blood cells (RBC's), during storage in bags, which could eventually be used as a quality check prior to transfusion....
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....
Many laboratory applications require liquid transfers between various labware formats. Due to varying requirements in their sample processing, different labware vessels are typically used for sample storage, processing and analysis tasks. Traditional multichannel pipettes were not designed to accommodate the wide variety of labware formats used today because their tip to tip spacing is optimized for use with standard 96-well microplates....
Oxford Gene Technology (OGT), The Molecular Genetics Company, held an exclusive workshop exploring the power of exon-focused microarrays in enhancing genetic syndrome research at the recent European Human Genetics Conference (ESHG). Three expert clinical researchers from across the globe shared their knowledge of enhanced CNV detection with OGT’s CytoSure™ Constitutional v3 array, helping viewers...
Product design and development firm Cambridge Consultants is working with medical device start-up WaveGuide Corporation on a world first to tackle the global problem of tuberculosis (TB), as well as other diseases. The two companies are developing a unique portable nuclear magnetic resonance (NMR) scanner to provide fast, low-cost, point-of-care (POC) testing for disease in developing countries...
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands advantageously position SP Scientific with capability to manufacture complete aseptic vial processing lines....
The University’s School is ranked in the top 16 such faculties worldwide and is the largest community of GeoScientists in the UK, home to 400 academics and research students. A reinterpretation of the typical laboratory layout will achieve transparency throughout the building, visually connecting write-up areas, laboratories, group rooms and offices...
This free software resource is available on the SP Scientific website**. Users obtain a starting point for primary drying duration and the maximum product temperature at the sublimation interface using pertinent information, such as shelf temperature and chamber pressure, from which an optimized freeze-drying cycle can be developed. The LMC is based on the steady-state heat and mass transfer model of primary drying developed by...
The Japanese regenerative medicine company ReproCELL Inc., has announced that two of its Group companies, Biopta and Reinnervate, will merge to form a new company, ReproCELL Europe Ltd. The merger is aimed at strengthening ReproCELL’s pharmaceutical industry-targeted drug discovery services and products through the integration of Biopta’s human tissue services with Reinnervate’s stem cell and 3D cell...
Themis successfully extended its existing license agreement with Institut Pasteur, France, which grants the company a broad access to a well-established virus vaccine vector technology. The safety and tolerability profile of the vector was already proven in a Phase I trial when the two partners used the technology platform for the development of a first in class Chikungunya vaccine...
Sartorius Stedim Biotech (SSB), a leading international supplier for the biopharmaceutical industry, announced the launched of a new Released N-Glycan Assay for the in-depth profiling of IgG glycosylation. This new physico-chemical assay, developed by SSB’s subsidiary BioOutsource and offered in combination with its unique Antibody Dependent Cell Cytotoxicity (ADCC) assay platform, combines data on the molecular structure...
Being able to overcome the inhibitory or enhancing properties of a sample is required by the BET monograph, the validation of which forms part of the test for the final product release of injectable drugs and medical devices. Many of the pharmaceutical products that are either in use or being developed today have characteristics that cause them to interfere with the BET....
The portfolio will include 38 polymers for sustained release of small molecule and selected peptide injectables, allowing customers to optimize and precisely control release kinetics of final drug products. The ability to better control and sustain the release of drugs allows for delivery via reduced numbers of injections with the same therapeutic efficacy...
This ground-breaking new centre, supported by the NHS and funded by the UK Government and the Medical Research Council (MRC) as part of the Glasgow City Region City Deal, will provide world-leading clinical research facilities and provide a hub for academic, scientific and NHS clinical expertise into brain imaging in diseases such as stroke, dementia and brain tumours....
The new approach offers cancer patients the opportunity to get gene testing at one of their routine cancer clinic appointments instead of having to be referred to a separate genetic testing clinic. As well as offering a more streamlined patient journey, the pathway is less resource intensive for health systems and could save the NHS millions of pounds per year, if implemented nationally....
The TF2000 uses a temperature gradient as the driving force for its separation of polymers and particles. Molecules affected by the thermal gradient undergo diffusion which enables separation by both their molar mass and chemical composition. This unique feature allows the separation of different materials having the same molar mass....
ELRIG (European Laboratory Research & Innovation Group) has announced its 10th Anniversary Drug Discovery meeting, which this year will take place at ACC in Liverpool, UK, located in the heart of the city beside the historic Albert Docks, from 13th-14th October 2016. ELRIG Drug Discovery is the premier meeting place in Europe for scientists from industry, biotech and academia engaged in pre-clinical drug discovery...
Seward Ltd, manufacturers of the renowned Stomacher® blender and creators of the Insterprep® range of instantly soluble sterile media, has teamed up with Scientific Laboratory Supplies (SLS) as their primary distribution partner for Insterprep in the UK. Insterprep is a new range of pre-weighed, sterile, granulated media available in Stomacher® bags or sachets. Designed to speed up and simplify sample preparation for...