Follow us...

 

Search News Archives

Channels

News

 

 

View Channel

Laboratory Products

 

 

View Channel

Special Offers and Promotions

 

Microscopy | Image Analysis

 

 

View Channel

Separation Science

 

 

View Channel

Coronavirus (COVID-19)

 

 

View Channel

Research & Case Studies

 

 

View Channel

Brochures & Literature

 

 

View Channel

 

Conferences | Events

Easy-to-Use Reversed-Phase Capillary Columns and Emitters Improve High-Resolution LC-MS Analysis

publication date: Mar 2, 2021
 | 
author/source: Thermo Fisher Scientific

easytouse-reversedphase-capillary-columns-and-emitters

 

The Thermo Scientific MAbPac Reversed-Phase Capillary HPLC Columns and Emitters achieve sensitive, reproducible and robust high throughput analysis with minimal sample volume

Proteomics, clinical peptides and biopharmaceutical research laboratories performing high throughput, high-performance liquid chromatography (HPLC), or liquid chromatography-mass spectrometry (LC-MS) analysis can now benefit from novel capillary chromatography columns and nano- and capillary emitters, specifically designed for highly sensitive top-down, middle-down analysis. These columns and emitters enable laboratories to achieve high-resolution, low-flow separations for intact proteins, monoclonal antibodies (mAbs) and peptides.

The Thermo Scientific MAbPac Reversed-Phase (RP) Capillary HPLC Column builds upon the separation power and reliability of the proven MAbPac RP chemistry in analytical flow. Together with the new Thermo Scientific EASY-Spray Nano and Capillary Emitters, the temperature-controlled MAbPac column enables maximum reliability and performance, while also providing excellent resolution, long column lifetime and low carry-over. The capillary format of the LC column improves sensitivity, achieving outstanding data results even with smaller sample volumes. The format makes the versatile column ideal for applications such as peptide mapping characterization and analysis of mAbs fragments, antibody drug conjugates (ADC) and PEGylated proteins.

"Medical and clinical research laboratories are looking to overcome the challenges in designing new biotherapeutic drug entities, for example, having limited sample volumes for analysis," said Molly Flick, vice president and general manager, chromatography consumables solutions, Thermo Fisher Scientific. "In order to break these barriers, the MAbPac RP capillary HPLC column, together with the new nano- and capillary flow emitters, provide increased sensitivity and ease of use for workflows. The new column enables laboratories to advance early stage medical and clinical research by reducing the sample size needed to gather meaningful results."

Erwin M. Schoof, PhD, associate professor and head of DTU proteomics core, DTU Bioengineering said, "We are really excited about the new emitters. The Thermo Scientific EASY-Spray Nano- and Capillary Emitters are robust and easy to install and use. They repeatedly deliver excellent performance and last for thousands of acquisitions."

The MAbPac column is available in a convenient EASY-Spray design, which delivers proven ease-of-use by taking advantage of "plug and spray" to low-flow LC. The standalone MAbPac RP Capillary LC column is designed with double nano viper fitters, positioned on each side of the column, enabling finger-tight grip to easily mount the column onto the system and eliminate dead volume. The nano- and capillary emitters are compatible for use with the Thermo Scientific EASY-Spray source and Thermo Scientific FAIMS Pro source. A simple hardware connection delivers continuous stable spray onto the MS system, enabling better reproducibility and robust nano- and capillary flow into LC-MS systems.

 

Learn more about the range

 

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $30 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. Our global team of more than 80,000 colleagues delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services and Patheon.

 

more news from Thermo


 


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners