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New Ultra-High Mass Range Mass Spectrometer Provides Solution for Analysis of Proteins and Protein Complexes
Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap Mass Spectrometer brings great sensitivity and high resolution to understand protein structure and interactions
Structural biologists and biopharmaceutical scientists now have access to an ultra-high mass range (UHMR) mass spectrometer (MS) that can be used to perform high quality native MS and top-down analyses and can provide novel insights into protein structure and protein-protein interactions.
Benefits of the new system include:
- Ultra-high resolution and orders of magnitude for great sensitivity, at up to 80,000 m/z, to resolve the small differences in masses needed to characterize intact biomolecular assemblies and complexes
- In-source trapping capability that enables improved transmission and controllable desolvation and fragmentation
- High mass quadrupole selection and high HCD fragmentation efficiency for better native top-down analysis than achievable with previous Thermo Fisher technology
When analysts combine the Q Exactive UHMR mass spectrometer with the integrated Thermo Scientific BioPharma Finder 3.0 Intact software for deconvolution and Thermo Scientific ProSight software, they can elevate their research by confirming intact molecular weight of proteins and complexes as well as by obtaining sequence information and identifying potential modifications.