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A Single Source for 3D Cell Culture
Greiner Bio-One presents new cell culture kits at Biotechnica 2015 in collaboration with U.S. specialist Nano3D Biosciences
Greiner Bio-One will be exhibiting new kits for 3D cell culture at the European Biotechnica trade show for biotechnology, life sciences and lab technology in Hanover, Germany. The kits – which are being distributed in cooperation with Nano3D Bio-sciences, based in Houston, Texas in the United States – simplify the cultivation of cells into three-dimensional structures. The physiological conditions of these types of 3D cultures are very similar to those in the body and thus allow for significant results for preclinical drug screen- ing, toxicology and cancer research. With compatible cell-repellent surface cell culture vessels and microplates, Greiner Bio-One offers an ideal platform for Nano3D’s technology.
New technology for 3D cell culture
90 percent of all active ingredient candidates for cancer drugs fail due to low clinical effective- ness or highly toxic side effects in the clinical phase, i.e. at a very late stage in the development process. Three-dimensional in-vitro assays offer a promising method in high-throughput screen- ing to enable a more conclusive evaluation of active ingredients at an early development phase.
Greiner Bio-One has partnered with Nano3D Biosciences to present innovative solutions for 3D cell culture. The 3D technology is based on magnetisation of cells using nanoparticles that at- tach themselves to the cell membrane. Development of three-dimensional spheroids or ring structures is initiated by briefly applying magnets.
Ideal combination – Nano3D technology and CELLSTAR cell-repellent surface
Greiner Bio-One CELLSTAR cell-repellent cell culture vessels and microplates support three- dimensional cell growth by preventing adherent cell growth on the vessels’ surface. Kits allow rapid development of three-dimensional model structures as well as co-culture of various cell lines using standard media and laboratory equipment. Easy-to-use in different formats, the plat- forms minimise risk of sample loss during experimental runs. Several studies have demon- strated that the magnetic particles have no effect on the growth characteristics and physiology of cells.
Kits contain CELLSTAR cell culture vessels with cell-repellent surface, a reagent to magnetise the cells (NanoShuttle) and the appropriate magnets. Most kit components are also available separately.