The Anti-Doping Control Laboratory at Barcelona’s Hospital del Mar Medical Research Institute (IMIM) is a world-recognized facility performing dope testing of athletes and animals for national and international sporting events, and was an early adopter of LGC Standards LoGiCal range of reference materials
Immaculada Figuera, a chemist in the laboratory, explained: “We test around 4,000 human and animal samples a year from sporting events around the world, screening urine, blood and serum samples for controlled substances. We perform a wide range of gas and liquid chromatography-based protocols, and use LoGiCal reference standards for both qualitative and quantitative analyses.”...
Read MoreSanofi-Aventis Puts A New Gas Chromatography Workhorse Through Its PacesJan 10, 2013
Thermo Fisher Scientific is pleased to announce a customer case study on the effective adoption of upgraded gas chromatography (GC) technology into an existing workflow with improved results and minimal effort
Dr. Dietrich Hilke, Head of Laboratory, Sanofi-Aventis, Deutschland GmbH, Frankfurt, and his team participated in the planning, testing, and evaluation of a new GC platform. Dr. Hilke’s laboratory analyzes 500 to 700 sample batches per year in a regulated environment for quality control of excipients, drug substances, and drug products. The team was able to directly transfer existing methods to the new GC system thus saving large amounts of time and effort....
Read MoreIon Chromatography: Metrohm publishes new Application Notes for the power industryNov 14, 2012
Metrohm publishes new Application Notes (ANs) on anion analysis in the power industry
In a recently published article, researchers from Novozymes Biopharma (Nottingham, UK) and Malvern Instruments (Malvern, UK) describe collaborative work using light scattering techniques to demonstrate the short- and long-term stability of the novel recombinant human albumins Albucult® and Recombumin®
These rAlbumins have been developed and optimized to deliver a safe, stable and regulatory-compliant product for therapeutic formulations. The teams applied the resolving and detection capabilities of size exclusion chromatography light scattering (SEC-LS) and dynamic light scattering (DLS) offered by Malvern systems to monitor the stability of these Novozymes products. The article ‘Tools for evaluating the stability of human recombinant albumins used in human therapeutics’ can be accessed at...
New Zetasizer Nano ZSP offers emerging rheology technique for weakly structured fluids
With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
Thermo Fisher Scientific is pleased to announce a direct-detection reversed-phase high-performance liquid chromatography (HPLC) chromatographic assay method that separates the congeners in gentamicin sulfate and gentamicin sulfate-containing ointments, solutions, and creams in just 15 minutes
Application Note 1005: Gentamicin Sulfate Assay by HPLC with Charged Aerosol Detection demonstrates that this approach is faster than previously published methods, with excellent separation between the gentamicin congeners and resolution of many impurities that can be present in fermentation-manufactured products....
Imagine being able to grow sustainable transportation fuels? Thanks to analytical technology from Bruker CAM, Energia Technologies, Inc., is one step closer towards addressing the emerging need for alternative liquid transportation biofuels
Its innovative SelectJETTM technology converts plant oils into biojet and biodiesel, which can serve as drop-in replacement to petroleum-based fuels. Now, using Bruker gas chromatography (GC) systems along with CompassCDS and SimDist Software, the research team at Energia Technologies can analyze their product quickly and easily, using the information to feedback into optimizing production processes. A full write-up of this inspiring case study is available...
Read MoreTwo Ion Chromatography Methods to Determine Sulfate and Total Chloride in ButanoSep 5, 2012
Thermo Fisher Scientific Inc. is pleased to announce the release of two simple ion chromatography (IC) analytical methods as per ASTM D7328-07 and ASTM D7319-09 for butanol, the next-generation biofuel
Application Note 296, Assay of Fuel-Grade Butanol for Total and Potential Sulfate and Total Chloride Per ASTM D7328-07
Application Note 297, Determination of Total and Potential Sulfate and Total Chloride in Fuel-Grade Butanol Per ASTM D7319-09
Two new application notes from Jenway demonstrate how the Genova Nano micro-volume spectrophotometer produces fast, accurate and reproducible results
The data presented shows how precise the instrument is when measuring DNA in terms of absorbance measurement both within and between instruments. With its ability to measure sample volumes as low as 0.5 µl the Genova Nano is shown to be ideally suited for DNA, RNA and protein measurements in life science laboratories. The application notes, ‘Accuracy and precision of the Genova Nano' and ‘Pierce 660 nm protein assay using the Genova Nano', are available for download...
Read MoreDetermination of Trace Sodium in Cranberry PowderAug 22, 2012
Thermo Fisher Scientific is pleased to announce a Reagent-FreeTMion chromatography (RFICTM) method that determines trace concentrations of sodium in cranberry powder, yielding results within 15% of those reported by the National Institute of Standards and Technology (NIST) and thus demonstrating the viability of this alternate analysis technique
The RFIC system enhances the level of automation and improves ease of use as well as inter- and intralaboratory data reproducibility.Application Note 1003: Determination of Trace Sodium in Cranberry Powder demonstrates use of electrolytic eluent generation with our cation-exchange column (Thermo Fisher Dionex IonPac CS12A column) and suppressed conductivity detection
Read MoreAutomated System Suitability Testing for Chromatographic InstrumentsAug 10, 2012Thermo Fisher Scientific Inc. is pleased to announce a new Technical Note on performing System Suitability Testing (SST) for liquid and gas chromatography methods and instrumentation.
Technical Note 708, Thermo Scientific Dionex Chromeleon 7 Chromatography Data System Software, outlines the many features of the software that are designed specifically to perform automated SST...
Read MoreThermo Fisher Scientific Publishes Applied Food Testing LibraryAug 9, 2012Thermo Fisher Scientific, Inc., the world leader in serving science, today announced that its new Applied Food Testing Library is now available online
This compilation of more than 230 application notes, case studies, validated methods, webinars and technical posters by industry experts is designed to help food science professionals master routine and special challenges. This highly-practical repository covers: allergens, authenticity and traceability, beverage and drinking water, chemical contaminants, food processing, microbiological organisms, non-targeted screening, physical contaminants, quality control and trace elements...
Read MoreBruker Post Three New SCION GC-MS TQ Application NotesAug 9, 2012Three new Application Notes evaluating the merits and varying applications of the double award winning SCIONTM gas chromatograph mass spectrometer triple quadrupole (GC-MS TQ), are now available from Bruker's dedicated SCION product website
This series of three Application Notes explore some of the innovative design features of Bruker's SCION TQ, highlighting the benefits of these features with data. The Application Notes include...
Read MoreReverse Engineering of polymers using nanoscale IR spectroscopy via AFM-IR Aug 6, 2012A recent publication in Spectroscopy Europe by lead authors from Kimberly Clark Corporation showed the use of AFM based nanoscale IR Spectroscopy for reverse engineering of polymeric multilayer films.
The Atomic Force Microscope (AFM) is a fairly common nanoscale characterization technique but its main drawback to date was its inability to provide chemical composition information from a sample. By combining the AFM with a tunable Infrared (IR) source, IR spectra with nanoscale spatial resolution can be collected. As film thicknesses in multilayer films continue to shrink, AFM-IR provides an important capability for sample analysis...
Read MoreFluorescence Detection Speeds Determination of Sialic AcidsAug 1, 2012Thermo Fisher Scientific is pleased to announce a new ultra high-performance liquid chromatography (UHPLC) method that allows high resolution of sialic acids in a 10 min analysis time and requires less organic solvent than other published methods.
Application Note 278: UHPLC Determination of Sialic Acids with Fluorescence Detection demonstrates that the sensitivity of fluorescence detection easily allows straightforward determination of sialic acids in the pmol range...
Read MoreBisphosphonate Pharmaceuticals and Excipients by Capillary IC-MSJul 25, 2012Thermo Fisher Scientific has developed a simple, fast, sensitive, and robust capillary ion chromatography (IC) analytical method to simultaneously quantify three bisphosphonate pharmaceuticals (etidronate, clodronate and tiludronate) and three commonly used excipients (benzoate, hydroxybenzoate and citrate).
Application Note 1001: Quantitative Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS uses a Thermo Scientific Dionex IonPac AS18-Fast capillary anion-exchange column to achieve chromatographic retention and resolution for target analytes. The elimination of derivatization steps simplifies the workflow and improves method throughput...
Read MoreOnyx Scientific to expand capabilitiesJul 25, 2012Chemistry expert Onyx Scientific has announced a collaboration with a purification specialist that will see the company broaden its offering to the global pharmaceutical and biotech industry.
The contract manufacturing organisation (CMO) has struck-up a strategic alliance with UK-based Reach Separations, which will allow it to deliver more specialist purification and separation services to bolster its early stage development services...
Read MoreThe forefathers of Shimadzu win the 2012 Pittcon Heritage AwardJul 9, 2012The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon) and the Chemical Heritage Foundation (CHF) recently bestowed the 2012 Pittcon Heritage Award on the founders of Shimadzu, a world leader in analytical instrumentation.
Father and son, Genzo Shimadzu, Sr. and Jr., who set up the company in the second half of the nineteenth century, helped to contribute towards the rapid modernization of Japan through the development of storage batteries and X-ray equipment...
Read MoreFluorescence Method Development Handbook for HPLC now availableJul 4, 2012Thermo Fisher Scientific is pleased to announce the release of a comprehensive Fluorescence Method Development Handbook.
Fluorescence method development is much more complex compared to other optical detectors such as UV or refractive index detection. For optimum results, it is important to optimize the different parameters in a systematic way. The 16-page guide explains fluorescence theory and its effects on experimental results during method development. It also demonstrates how to benefit from the unique features of our fluorescence detectors...
Read MoreRapid and Sensitive Determination of Biofuel Sugars by ICJun 27, 2012Thermo Fisher Scientific Inc. has developed a rapid ion chromatogaphy (IC) method to determine the common sugars in samples from solutions used for biofuel production.
The method described in Application Note 282: Rapid and Sensitive Determination of Biofuel Sugars by Ion Chromatography requires minimal sample pretreatment and uses a Dionex CarboPac SA10 anion-exchange column with electrolytically generated hydroxide eluent and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD).
Read MoreIC for the people Jun 25, 2012This year it is 25 years since Metrohm launched its first ion chromatograph, the 690 ion chromatograph. Since then Metrohm has profoundly changed ion chromatography with instruments that are simple to use, robust, and affordable.
In the early 1980s ion chromatography was already around as an analytical technique. However, it was very expensive and also rather difficult to use. Metrohm set out to change this with an ion chromatograph engineered to be simple to use, robust, and above all, affordable. The result was the 690 ion chromatograph, which was launched in 1987. At the time it cost only half as much as the competition's instruments...
Read MoreDetermination of Tartrate in Drug Products in Just 10 MinutesJun 21, 2012Thermo Fisher Scientific is pleased to announce two new ion chromatography (IC) methods designed to reduce time and labor and increase accuracy when determining tartrate in drug products containing tolterodine tartrate.
Application Note 1002: Determination of Tartaric Acid in Tolterodine Tartrate Drug Products by IC with Suppressed Conductivity Detection demonstrates that these methods are accurate and reproducible, with analysis times as low as 10 minutes. Both approaches use an electrolytic suppressor, which eliminates the time and effort to prepare dilute sulfuric acid regenerant...
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Dr. Dietrich Hilke, Head of Laboratory, Sanofi-Aventis, Deutschland GmbH, Frankfurt, and his team participated in the planning, testing, and evaluation of a new GC platform. Dr. Hilke’s laboratory analyzes 500 to 700 sample batches per year in a regulated environment for quality control of excipients, drug substances, and drug products. The team was able to directly transfer existing methods to the new GC system thus saving large amounts of time and effort....
The new applications enable monitoring of corrosion inhibitors and of critical trace ions (anions and cations) in water matrices from several types of reactors...
These rAlbumins have been developed and optimized to deliver a safe, stable and regulatory-compliant product for therapeutic formulations. The teams applied the resolving and detection capabilities of size exclusion chromatography light scattering (SEC-LS) and dynamic light scattering (DLS) offered by Malvern systems to monitor the stability of these Novozymes products. The article ‘Tools for evaluating the stability of human recombinant albumins used in human therapeutics’ can be accessed at...
With the recent launch of the new top of the range Zetasizer Nano ZSP system, Malvern Instruments has added dynamic light scattering (DLS) Microrheology to its portfolio of materials characterization techniques. To introduce this powerful technique, the company has published an in-depth paper that explains the background to microrheology, and how it can be used to investigate the rheological properties of even the most weakly structured fluids, using sample volumes on the microliter scale. ‘An Introduction to DLS Microrheology’ includes data for protein (bovine serum albumin (BSA)) and polyethylene oxide (PEO) solutions that illustrate the significance and usefulness of the method. It is freely available from the Malvern website.
Application Note 1005: Gentamicin Sulfate Assay by HPLC with Charged Aerosol Detection demonstrates that this approach is faster than previously published methods, with excellent separation between the gentamicin congeners and resolution of many impurities that can be present in fermentation-manufactured products....
Its innovative SelectJETTM technology converts plant oils into biojet and biodiesel, which can serve as drop-in replacement to petroleum-based fuels. Now, using Bruker gas chromatography (GC) systems along with CompassCDS and SimDist Software, the research team at Energia Technologies can analyze their product quickly and easily, using the information to feedback into optimizing production processes. A full write-up of this inspiring case study is available...
Application Note 296, Assay of Fuel-Grade Butanol for Total and Potential Sulfate and Total Chloride Per ASTM D7328-07
The data presented shows how precise the instrument is when measuring DNA in terms of absorbance measurement both within and between instruments. With its ability to measure sample volumes as low as 0.5 µl the Genova Nano is shown to be ideally suited for DNA, RNA and protein measurements in life science laboratories. The application notes, ‘Accuracy and precision of the Genova Nano' and ‘Pierce 660 nm protein assay using the Genova Nano', are available for download...
The RFIC system enhances the level of automation and improves ease of use as well as inter- and intralaboratory data reproducibility.Application Note 1003: Determination of Trace Sodium in Cranberry Powder demonstrates use of electrolytic eluent generation with our cation-exchange column (Thermo Fisher Dionex IonPac CS12A column) and suppressed conductivity detection
Technical Note 708, Thermo Scientific Dionex Chromeleon 7 Chromatography Data System Software, outlines the many features of the software that are designed specifically to perform automated SST...
This compilation of more than 230 application notes, case studies, validated methods, webinars and technical posters by industry experts is designed to help food science professionals master routine and special challenges. This highly-practical repository covers: allergens, authenticity and traceability, beverage and drinking water, chemical contaminants, food processing, microbiological organisms, non-targeted screening, physical contaminants, quality control and trace elements...
This series of three Application Notes explore some of the innovative design features of Bruker's SCION TQ, highlighting the benefits of these features with data. The Application Notes include...
The Atomic Force Microscope (AFM) is a fairly common nanoscale characterization technique but its main drawback to date was its inability to provide chemical composition information from a sample. By combining the AFM with a tunable Infrared (IR) source, IR spectra with nanoscale spatial resolution can be collected. As film thicknesses in multilayer films continue to shrink, AFM-IR provides an important capability for sample analysis...
Application Note 278: UHPLC Determination of Sialic Acids with Fluorescence Detection demonstrates that the sensitivity of fluorescence detection easily allows straightforward determination of sialic acids in the pmol range...
Application Note 1001: Quantitative Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS uses a Thermo Scientific Dionex IonPac AS18-Fast capillary anion-exchange column to achieve chromatographic retention and resolution for target analytes. The elimination of derivatization steps simplifies the workflow and improves method throughput...
The contract manufacturing organisation (CMO) has struck-up a strategic alliance with UK-based Reach Separations, which will allow it to deliver more specialist purification and separation services to bolster its early stage development services...
Father and son, Genzo Shimadzu, Sr. and Jr., who set up the company in the second half of the nineteenth century, helped to contribute towards the rapid modernization of Japan through the development of storage batteries and X-ray equipment...
Fluorescence method development is much more complex compared to other optical detectors such as UV or refractive index detection. For optimum results, it is important to optimize the different parameters in a systematic way. The 16-page guide explains fluorescence theory and its effects on experimental results during method development. It also demonstrates how to benefit from the unique features of our fluorescence detectors...
The method described in Application Note 282: Rapid and Sensitive Determination of Biofuel Sugars by Ion Chromatography requires minimal sample pretreatment and uses a Dionex CarboPac SA10 anion-exchange column with electrolytically generated hydroxide eluent and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD).
In the early 1980s ion chromatography was already around as an analytical technique. However, it was very expensive and also rather difficult to use. Metrohm set out to change this with an ion chromatograph engineered to be simple to use, robust, and above all, affordable. The result was the 690 ion chromatograph, which was launched in 1987. At the time it cost only half as much as the competition's instruments...
Application Note 1002: Determination of Tartaric Acid in Tolterodine Tartrate Drug Products by IC with Suppressed Conductivity Detection demonstrates that these methods are accurate and reproducible, with analysis times as low as 10 minutes. Both approaches use an electrolytic suppressor, which eliminates the time and effort to prepare dilute sulfuric acid regenerant...