The ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method described in Application Note 294: Simultaneous Analysis of Water-Soluble Vitamins in Vitamin-Enriched Beverages and Multivitamin Dietary Supplements by UHPLC-MS/MS was optimized for total resolution of all target analytes on a reversed-phase (RP) C30 column with a rapid separation LC (RSLC) system and a triple stage quadrupole mass spectrometer. Accurate quantitative measurements for vitamins are required to ensure product quality and regulatory compliance as well as to monitor vitamin intake...
Read MoreEffective Determination of Dibasic AcidsJun 13, 2012Thermo Fisher Scientific is proud to announce an effective new method for the determination of succinic, glutaric, and adipic acids in solutions of mixed dibasic acids generated during cyclohexane oxidation.
Application Note 285: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone Production demonstrates use of our liquid chromatography system (Thermo Scientific Dionex UltiMateTM 3000 RSLC system) with organic acid analytical column (Thermo Scientific AcclaimTM OA column) and mass spectrometry (MS) detection to achieve a fast baseline separation of these three dibasic acids with good resolution values (Rs ≥ 2.6)... Read MoreChoosing the Right Oligonucleotide Modification for Your NeedsJun 13, 2012Latest issue of IDT's DECODED newsletter offers informative oligonucleotide selection guide
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a guide to choosing the right oligonucleotide modification in this quarter's edition of the company's DECODEDnewsletter. As IDT offers hundreds of useful modifications for oligonucleotides, choosing the appropriate one for your work can be confusing. The article provides insightful information to help when choosing the right modification, including a detailed list of the modification categories...
Read MoreNovel Inositol Method Using Ion ChromatographyJun 7, 2012Thermo Fisher Scientific is pleased to announce a new Ion Chromatography (IC) method developed by Covance Laboratories Inc. for the total determination of free and total myo-inositol in foods, feeds, and infant formulas.
The novel approach developed by Covance application chemists uses microwave-assisted acid hydrolysis followed by enzymatic treatment and quantitation by high performance anion-exchange chromatography and pulsed amperometric detection (HPAED-PAD) using a Thermo Scientific Dionex ion chromatography system and carbohydrate analytical columns (Thermo Scientific Dionex CarboPac columns)...
Read MoreAnalysis of Nitrate and Nitrite in MilkMay 23, 2012Thermo Fisher Scientific Inc. is pleased to announce a new application for the determination of nitrite and nitrate in milk by ion chromatography (IC) with suppressed conductivity detection using in-line sample preparation. Application Note 279: Time Savings and Improved Reproducibility of Nitrate and Nitrite Ion Chromatography Determination in Milk Samples describes the method where the prepared sample is separated on the high-capacity Thermo Scientific Dionex IonPac TM AS20 hydroxide-selective anion-exchange column to resolve nitrite and nitrate from the remaining sample components...Read MoreHPLC-CAD Improves Determination of Triterpenes in Gota KolaMay 22, 2012Thermo Fisher Scientific is pleased to announce a new method that uses high-performance liquid chromatography (HPLC) combined with charged aerosol detection (CAD) to enable improved quantitation of triterpene content in gotu kola. Low-wavelength UV detection commonly used for triterpene analysis often results in strongly sloping baselines, and interferences from minor components can adversely affect quantitation. Customer Application Note (CAN) 111: Determination of Triterpenes in Centella asiatica (Gotu Kola) by HPLC-CAD demonstrates that charged aerosol detection minimizes these interferences and improves the baseline, thereby enabling improved quantitation of triterpenes in gotu kola... Read MoreMalvern team presents May 22, 2012Malvern Instruments light scattering specialists Dr Ana Morfesis and Dr Ulf Nobbmann, will present a poster on ‘Nanoparticle characterization by light scattering' as part of the 86th ACS Colloid and Surface Science Symposium being held at the University of Baltimore in Maryland, USA, June 10-13, 2012. Their poster will be displayed from 5.30 until 7.30 pm on Monday June 11 in a session held in the exhibition area, where delegates will also be able to visit the Malvern booth to find out more about the company's full range of systems for nanoparticle characterization, including the market leading Zetasizer Nano.
Read MoreDetermination of Ginsenosides in Panax Ginseng - New method announced by Thermo Fisher ScientificMay 15, 2012Thermo Fisher Scientific is pleased to announce a new method that uses the Thermo Scientific Dionex Corona CAD Charged Aerosol Detector to provide a reliable alternative to low-wavelength UV detection. Customer Application Note (CAN) 112: Determination of Ginsenosides inPanax ginseng by HPLC-CAD demonstrates that charged aerosol detection does not overrespond to strong chromophores, thereby reducing interferences. Baseline slopes are not as pronounced or as variable, making peak area determinations more reliable...
Read MoreAnalysis of Organic Acids in WastewaterMay 14, 2012Thermo Fisher Scientific is pleased to announce a new combined method for the accurate determination of organic acids in a wastewater sample. Application Note 291: Determination of Organic Acids in Wastewater Using Ion-Exclusion Chromatography and On-Line Carbonate Removaldemonstrates that ion-exclusion chromatography excludes the inorganic anions present in the sample. A Thermo Scientific Dionex Carbonate Removal Device (CRD 200) is also needed to remove carbonate on line. Inorganic anions and carbonate can interfere when determining organic acids in wastewater using anion-exchange chromatography...
Read MorePurdue University researchers use nanoscale IR spectroscopy via AFM-IR to provide key insights into drug-polymer blendsMay 11, 2012Two new papers are going to press featuring the use of Anasys Instruments' nanoIRTM system by Professor Lynne S. Taylor's group in the Department of Industrial and Physical Pharmacy at Purdue University. In each study, miscibility of pharmaceutically relevant blends was examined and specific sub-micrometer-sized domains characterized using standard atomic force microscopy (AFM) and nanoscale Infrared spectroscopy (AFM-IR)...
Read MoreNew Malvern download with detailed Zetasizer specifications helps users match system with applicationMay 9, 2012In line with a policy of continuous improvement, Malvern Instruments has reviewed, verified and published updated specifications for the Zetasizer series of dynamic light scattering (DLS) particle characterization systems, all fully backed by measurements on real samples. Full updated specification details are available online...
Read MoreAnalysis of Carbohydrates in Coffee in 10 minsMay 2, 2012Thermo Fisher Scientific is pleased to announce a new approach using high-performance anion-exchange ( HPAE) chromatography with pulsed amperometric detection (PAD) for the determination of carbohydrates in extracts from instant coffee and green coffee beans. Application Note 280: Carbohydrate in Coffee: AOAC Method 995.13 vs a New Fast Ion Chromatography Methodcompares two methods: the Association of Analytical Chemists ( AOAC) official method 995.13 and a fast method using the CarboPac TM SA10 colum...
Read MoreDetermination of Steviol Glycoside in SweetenersApr 17, 2012Thermo Fisher Scientific Inc. is pleased to announce an economical new method that uses high-performance liquid chromatography ( HPLC) with charged aerosol and UV detections to determine steviol glycosides in consumer sweeteners. Application Note 293: Steviol Glycoside Determination by HPLC with Charged Aerosol and UV Detections Using the Acclaim Trinity P1 Columndemonstrates that only 3-9 mL of mobile phase/sample are required, compared to 25-60 mL/sample for the Joint FAO/WHO Commission on Food Additives ( JECFA) and U.S. Pharmacopeia (USP) methods, respectively. The reduction in mobile phase use saves both time and resources during mobile phase preparation and also reduces waste...
Read MoreReliable method for characterising PFC'sApr 16, 2012Exeter Analytical has developed a reliable analytical method for accurately determining the percentage Carbon (C), Hydrogen (H) and Nitrogen (N) content of polyfluorinated compounds (PFCs). Polyfluorinated compounds are extremely thermally and chemically stable and have soil, water and fat-repellent properties. They are nearly non-biodegradable and accumulate in the environment and the food chain...
Read MoreHPLC Analysis of 6 Active Components of Caulis LoniceraeApr 13, 2012Thermo Fisher Scientific Inc. is pleased to announce an efficient, comprehensive HPLC QC method using an Acclaim Phenyl-1 Column for the separation of all six main active components of Caulis Lonicerae, an important traditional Chinese medicine. To regulate this natural treatment used for acute fever, headache, respiratory infection, and epidemic diseases, the Pharmacopoeia of the People's Republic of China (PPRC) requires two different methods, which combined only identify two main target components...
Read MoreSimple, Fast Determination of Phytic Acid in Soybeans and Black Sesame SeedsApr 12, 2012Thermo Fisher Scientific Inc. is pleased to announce a simple, fast (< 10 min per injection) isocratic method for the determination of phytic acid (as phytate) in soybeans and black sesame seeds by using a hydroxide-selective column combined with a Reagent-FreeTM ion chromatography (RFICTM) system, as described in Application Note 295, Determination of Phytic Acid in Soybeans and Black Sesame Seeds. The RFIC system eliminated the required time and possible errors associated with manual eluent preparation and the method was shown to be accurate and reproducible for these two samples, and should be applicable to other food samples...
Read MoreCheese aromas pinpointed by innovative techniqueApr 5, 2012Food scientists working in the dairy industry are set to benefit from the development of a powerful new technique for analysing the aroma profile of cheese. The innovative method, which uses technology developed by Markes International to analyse vapours emitted by a sample, will enable analysts to identify the specific chemical compounds released by different cheeses, even when they are present at trace levels and have low odour thresholds...
Read MoreBruker Post Three New SCION GC-MS Application Notes for DownloadApr 2, 2012A series of three new Application Notes describing multi-residue analysis in complex food matrix samples and environmental monitoring using the Bruker SCIONTM tandem mass spectrometry (MS) coupled to gas chromatography (GC-MS/MS) are now available on Bruker's dedicated SCION product website...
Read MorePractical Guidelines for Capillary Anion-Exchange ChromatographyApr 2, 2012Thermo Fisher Scientific is pleased to announce a technical note describing procedures and practices that help chromatographers get the most out of their capillary ion-chromatography system. Technical Note 113: Practical Guidance for Using Capillary Anion Chromatography presents tips and techniques that will help ensure that good chromatographic results are obtained as system volumes are reduced for capillary IC...
Read MoreNew Article for Download: Meeting the Expanding Needs of Global Food Testing: Analysis of Pesticides in Vegetable Matrix BrukerMar 12, 2012A recent article, originally published in "Innovations in Food Technology" (November, 2011), has been made available online at ScionHasArrived.com. Authored by Zicheng Yang & Kefei Wang, experts from Bruker's Chemical and Applied Markets division (Fremont, California) the article explores the globalization of food supplies, and discusses how manufacturers and other businesses are coping with the extensive need for food testing.
Read MoreMalvern specialist presents GPC/SEC benefits at Chromatographic Society meetingFeb 29, 2012A separation technique specialist from Malvern Instruments will speak at the upcoming symposium ‘Chromatographic characterisation and purification techniques for Biopharm', a meeting with a packed programme of presentations and workshops that will focus on monoclonal antibody-derived drugs. This 2-day event is organised by the Chromatographic Society and will be hosted at the GlaxoSmithKline Medicines Research Centre in Stevenage, UK on 14/15 March 2012. Malvern is also one of the symposium sponsors...
Read MoreDirect HPAE-PAD Analysis of Sialic Acids in Glycoprotein HydrolyzatesFeb 3, 2012Thermo Fisher Scientific is pleased to announce a new method that allows sialic acids in five representative glycoproteins to be determined by acid hydrolysis release and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD). Application Update 180: Direct Determination of Sialic Acids in Glycoprotein Hydrolyzates by HPAE-PAD demonstrates that determination of N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on a Thermo Scientific Dionex CarboPac PA20 Fast Sialic Acid column is specific and direct...
Read More
The ultrahigh-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method described in Application Note 294: Simultaneous Analysis of Water-Soluble Vitamins in Vitamin-Enriched Beverages and Multivitamin Dietary Supplements by UHPLC-MS/MS was optimized for total resolution of all target analytes on a reversed-phase (RP) C30 column with a rapid separation LC (RSLC) system and a triple stage quadrupole mass spectrometer. Accurate quantitative measurements for vitamins are required to ensure product quality and regulatory compliance as well as to monitor vitamin intake...
Application Note 285: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone Production demonstrates use of our liquid chromatography system (Thermo Scientific Dionex UltiMateTM 3000 RSLC system) with organic acid analytical column (Thermo Scientific AcclaimTM OA column) and mass spectrometry (MS) detection to achieve a fast baseline separation of these three dibasic acids with good resolution values (Rs ≥ 2.6)...
Integrated DNA Technologies (IDT), the world leader in oligonucleotide synthesis, provides a guide to choosing the right oligonucleotide modification in this quarter's edition of the company's DECODED newsletter. As IDT offers hundreds of useful modifications for oligonucleotides, choosing the appropriate one for your work can be confusing. The article provides insightful information to help when choosing the right modification, including a detailed list of the modification categories...
The novel approach developed by Covance application chemists uses microwave-assisted acid hydrolysis followed by enzymatic treatment and quantitation by high performance anion-exchange chromatography and pulsed amperometric detection (HPAED-PAD) using a Thermo Scientific Dionex ion chromatography system and carbohydrate analytical columns (Thermo Scientific Dionex CarboPac columns)...
Thermo Fisher Scientific Inc. is pleased to announce a new application for the determination of nitrite and nitrate in milk by ion chromatography (IC) with suppressed conductivity detection using in-line sample preparation. Application Note 279: Time Savings and Improved Reproducibility of Nitrate and Nitrite Ion Chromatography Determination in Milk Samples describes the method where the prepared sample is separated on the high-capacity Thermo Scientific Dionex IonPac TM AS20 hydroxide-selective anion-exchange column to resolve nitrite and nitrate from the remaining sample components...
Thermo Fisher Scientific is pleased to announce a new method that uses high-performance liquid chromatography (HPLC) combined with charged aerosol detection (CAD) to enable improved quantitation of triterpene content in gotu kola. Low-wavelength UV detection commonly used for triterpene analysis often results in strongly sloping baselines, and interferences from minor components can adversely affect quantitation. Customer Application Note (CAN) 111: Determination of Triterpenes in Centella asiatica (Gotu Kola) by HPLC-CAD demonstrates that charged aerosol detection minimizes these interferences and improves the baseline, thereby enabling improved quantitation of triterpenes in gotu kola...
Malvern Instruments light scattering specialists Dr Ana Morfesis and Dr Ulf Nobbmann, will present a poster on ‘Nanoparticle characterization by light scattering' as part of the 86th ACS Colloid and Surface Science Symposium being held at the University of Baltimore in Maryland, USA, June 10-13, 2012. Their poster will be displayed from 5.30 until 7.30 pm on Monday June 11 in a session held in the exhibition area, where delegates will also be able to visit the Malvern booth to find out more about the company's full range of systems for nanoparticle characterization, including the market leading Zetasizer Nano.
Thermo Fisher Scientific is pleased to announce a new method that uses the Thermo Scientific Dionex Corona CAD Charged Aerosol Detector to provide a reliable alternative to low-wavelength UV detection. Customer Application Note (CAN) 112: Determination of Ginsenosides in Panax ginseng by HPLC-CAD demonstrates that charged aerosol detection does not overrespond to strong chromophores, thereby reducing interferences. Baseline slopes are not as pronounced or as variable, making peak area determinations more reliable...
Thermo Fisher Scientific is pleased to announce a new combined method for the accurate determination of organic acids in a wastewater sample. Application Note 291: Determination of Organic Acids in Wastewater Using Ion-Exclusion Chromatography and On-Line Carbonate Removal
Two new papers are going to press featuring the use of Anasys Instruments' nanoIRTM system by Professor Lynne S. Taylor's group in the Department of Industrial and Physical Pharmacy at Purdue University. In each study, miscibility of pharmaceutically relevant blends was examined and specific sub-micrometer-sized domains characterized using standard atomic force microscopy (AFM) and nanoscale Infrared spectroscopy (AFM-IR)...
In line with a policy of continuous improvement, Malvern Instruments has reviewed, verified and published updated specifications for the Zetasizer series of dynamic light scattering (DLS) particle characterization systems, all fully backed by measurements on real samples. Full updated specification details are available online...
Thermo Fisher Scientific is pleased to announce a new approach using high-performance anion-exchange ( HPAE) chromatography with pulsed amperometric detection (PAD) for the determination of carbohydrates in extracts from instant coffee and green coffee beans. Application Note 280: Carbohydrate in Coffee: AOAC Method 995.13 vs a New Fast Ion Chromatography Method
Thermo Fisher Scientific Inc. is pleased to announce an economical new method that uses high-performance liquid chromatography ( HPLC) with charged aerosol and UV detections to determine steviol glycosides in consumer sweeteners. Application Note 293: Steviol Glycoside Determination by HPLC with Charged Aerosol and UV Detections Using the Acclaim Trinity P1 Column
Exeter Analytical has developed a reliable analytical method for accurately determining the percentage Carbon (C), Hydrogen (H) and Nitrogen (N) content of polyfluorinated compounds (PFCs). Polyfluorinated compounds are extremely thermally and chemically stable and have soil, water and fat-repellent properties. They are nearly non-biodegradable and accumulate in the environment and the food chain...
Thermo Fisher Scientific Inc. is pleased to announce an efficient, comprehensive HPLC QC method using an Acclaim Phenyl-1 Column for the separation of all six main active components of Caulis Lonicerae, an important traditional Chinese medicine. To regulate this natural treatment used for acute fever, headache, respiratory infection, and epidemic diseases, the Pharmacopoeia of the People's Republic of China (PPRC) requires two different methods, which combined only identify two main target components...
Thermo Fisher Scientific Inc. is pleased to announce a simple, fast (< 10 min per injection) isocratic method for the determination of phytic acid (as phytate) in soybeans and black sesame seeds by using a hydroxide-selective column combined with a Reagent-FreeTM ion chromatography (RFICTM) system, as described in Application Note 295, Determination of Phytic Acid in Soybeans and Black Sesame Seeds. The RFIC system eliminated the required time and possible errors associated with manual eluent preparation and the method was shown to be accurate and reproducible for these two samples, and should be applicable to other food samples...
Food scientists working in the dairy industry are set to benefit from the development of a powerful new technique for analysing the aroma profile of cheese. The innovative method, which uses technology developed by Markes International to analyse vapours emitted by a sample, will enable analysts to identify the specific chemical compounds released by different cheeses, even when they are present at trace levels and have low odour thresholds...
A series of three new Application Notes describing multi-residue analysis in complex food matrix samples and environmental monitoring using the Bruker SCIONTM tandem mass spectrometry (MS) coupled to gas chromatography (GC-MS/MS) are now available on Bruker's dedicated SCION product website...
Thermo Fisher Scientific is pleased to announce a technical note describing procedures and practices that help chromatographers get the most out of their capillary ion-chromatography system. Technical Note 113: Practical Guidance for Using Capillary Anion Chromatography presents tips and techniques that will help ensure that good chromatographic results are obtained as system volumes are reduced for capillary IC...
A recent article, originally published in "Innovations in Food Technology" (November, 2011), has been made available online at ScionHasArrived.com. Authored by Zicheng Yang & Kefei Wang, experts from Bruker's Chemical and Applied Markets division (Fremont, California) the article explores the globalization of food supplies, and discusses how manufacturers and other businesses are coping with the extensive need for food testing.
A separation technique specialist from Malvern Instruments will speak at the upcoming symposium ‘Chromatographic characterisation and purification techniques for Biopharm', a meeting with a packed programme of presentations and workshops that will focus on monoclonal antibody-derived drugs. This 2-day event is organised by the Chromatographic Society and will be hosted at the GlaxoSmithKline Medicines Research Centre in Stevenage, UK on 14/15 March 2012. Malvern is also one of the symposium sponsors...
Thermo Fisher Scientific is pleased to announce a new method that allows sialic acids in five representative glycoproteins to be determined by acid hydrolysis release and high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD). Application Update 180: Direct Determination of Sialic Acids in Glycoprotein Hydrolyzates by HPAE-PAD demonstrates that determination of N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on a Thermo Scientific Dionex CarboPac PA20 Fast Sialic Acid column is specific and direct...