Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Integrating matrix into 3D spheroid culture enables high throughput measurement of cell invasion

3D Culture 96-Well BME Cell Invasion Assay

AMSBIO has announced the launch of the 3D Culture 96-Well BME Cell Invasion Assay to address the growing need for more complete and physiologically predictive cancer invasion models


Invasive migration is a fundamental function underlying cellular processes such as angiogenesis, embryonic development, immune response, metastasis, and invasion of cancer cells. AMSBIO's new 3D Culture 96-Well BME Cell Invasion Assay offers a flexible, standardized, high-throughput format for quantitating the degree to which invasive cells in 3D spheroid cultures penetrate a barrier consisting of basement membrane components in response to chemo attractants and/or inhibiting compounds.

There is growing evidence that tumor cell aggregates or spheroids provide a more representative model of tumors in vivo than can be achieved with conventional adherent monolayers. Such spheroids exhibit several relevant physiological traits including similar morphology, the formation of cell-cell bonds, decreased proliferation rates, increased cell survival, tumor dormancy, and a hypoxic core. Applying this model to in a 3D culture invasion assay provides a more physiological approach for assessing tumor invasion and providing a visual component that can be quantitated through image analysis.

The new 3D Culture 96 Well BME Cell Invasion Assay uses a 3D Culture Qualified 96-Well Spheroid Formation Plate alongside a specialized Spheroid Formation extracellular matrix to drive aggregation and/or spheroid formation of cells. Upon completion of spheroid formation, the spheroid is embedded in an invasion matrix composed of basement membrane proteins. This matrix forms a hydrogel network on which invasive cells can travel. At this point, invasion modulating agents can be applied to the system to evaluate the impact on cell response. Cell invasion is visualized microscopically and can be quantitated through image analysis software.

For further information please click here.

 

About AMS Biotechnology

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized as a leading international provider of unique, innovative products & custom services for life science research. The AMSBIO range includes over 23,000 polyclonal & monoclonal antibodies, peptides, recombinant proteins, extracellular matrix, molecular detection reagents, & tissue DNA, RNA, protein & microarray products. Key research areas include: apoptosis, cell invasion & migration, cell signaling, DNA damage, 3D culture, electrophoresis, glycobiology, post-translational modification & stem cell biology.


 


If you have not logged into the website then please enter your details below.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events