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Simplified Chiral Separations - Lux
Phenomenex Inc., a global leader in the manufacture of separation science consumables, introduces the LuxTM Amylose-2 chiral column, adding unique new selectivity to its HPLC solutions for the identification and resolution of enantiomers. The new column chemistry incorporates an amylose backbone with a novel 5-chloro-2-methylphenylcarbamate derivative to give chiral chromatographers an additional selectivity option for these difficult separations. The Lux Amylose-2 columns complement Phenomenex's recently introduced Lux Cellulose-1 and -2 chiral offerings.
The demand for chiral separations in pharmaceutical research has been on the rise due to more stringent FDA mandates covering drug candidates. Enantiomers -- mirror images that cannot be superimposed on each other -- must be screened separately on their pharmacodynamic and pharmacokinetic properties. Yet chiral molecules are often difficult to separate and identify using traditional chromatography tools. The identification of chiral molecules is also important in toxicology studies, flavor and fragrance analysis and environmental applications such as pesticide analysis.
"Amylose backbones have already demonstrated broad enantioselectivity in chiral analysis," explained Jason Lam, brand manager for Phenomenex. "The structure of Lux Amylose-2, combined with our unique halogenated derivative, resolves a wide range of enantiomers with unique chiral selectivity, giving chromatographers another tool for these difficult analyses."
Lux columns are offered in 3µm and 5µm particle sizes, packed for analytical-scale use or AXIATM-packed for preparative applications.
Phenomenex is a global technology leader committed to developing novel separation, purification and analytical chemistry solutions for the life sciences and related industries. Phenomenex's core technologies include products for liquid chromatography, gas chromatography, sample preparation, bulk purification chromatographic media, and chromatography accessories and equipment. For more information on Phenomenex, visit www.phenomenex.com/.