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All articles from AMS Biotechnology (Europe) Ltd

  ScreenIn3D Innovation Draws Accolades

ScreenIn3D, a partner of AMSBIOScreenIn3D, a partner of AMSBIO, reports on the accolades it has received following the recent launch of its novel microfluidic cancer screening service. Combining the latest advances in microfluidics and 3D culture - the service uses an optimised screening platform targeted at improving anticancer drug treatment and accelerating development of new personalised medicine solutions. At the recent Miptec conference in Basle, Switzerland - ScreenIn3D was one of 60 global organisations invited to showcase its cutting-edge life science technologies....

 

  Circulating Tumor DNA Reference Standards

test tubeAMSBIO announce the launch of a new range of circulating tumor DNA (ctDNA) Reference Standards for cancer disease management research. A critical goal in cancer disease management is early detection. When detected early, cancer progression can be arrested using techniques such as targeted therapy, chemotherapy and surgery thereby increasing the chances of survival and a higher quality of life. Liquid biopsy offers the promise of providing a quick Liquid biopsy offers the promise of providing a quick, non-invasive and cost-effective alternative...

 

  Engineering Immune Cells to Treat Cancers

cancer cellsAMSBIO produce a growing range of experimental cell lines, recombinant proteins and screening services to advance the search for new Chimeric Antigen Receptor (CAR T) cell therapies to treat cancers. For years, the foundations of cancer treatment were surgery, chemotherapy, and radiation therapy....

 

  Flexible & Precise Control of Gene Expression

Gene Editing SystemThe TUNR Flexible Gene Editing System from AMSBIO allows you to precisely control the expression of your gene of interest. Leveraging a CRISPR-Cas9 system for targeted integration of a polyA track at a precise location within the targeted gene, our kits are custom-designed for your project and include everything you need to tune gene expression in your favorite cell line. AMSBIO TUNR kits allow you to...

 

  Exosome Isolation Manufacturing & Characterization

neurodegenerative diseasesAMSBIO has announced an exosome isolation, manufacturing and characterization service to enable R&D groups to accelerate their discovery and development activities. Exosomes are small membrane vesicles with a size ranging from 40 to 100 nm. They are known to serve as functional mediators in cell interaction leading to cancer metastasis and have also been implicated in neurodegenerative diseases....

 

  Powerful CRISPR/Cas9 Gene Editing Kits

CRISPRAMSBIO has introduced new CRISPR / Cas9 editing kits for gene knock-out, gene knock-in and gene mutation applications. The latest tool in genome science – CRISPR/Cas9 is a simple and efficient genome editing tool which allows for specific genome disruption and replacement resulting in high specificity and low cell toxicity.

 

  AMSBIO Launches 3d-iPSC Matrix

MyEZGel 3D-iPSC MatrixAMSBIO announces MyEZGel™ 3D-iPSC Matrix - a powerful new tool for in vitro 3D human induced pluripotent stem cell (hiPSC) culture, enabling more accurate in vivo predictions in life science research and development. MyEZGel™ 3D-iPSC is a synthetic xeno-free hydrogel matrix inspired by muscle and spider silk proteins....

 

  AMSBIO Launch New Screening Company

ScreenIn3D (Glasgow, UK) is a new joint venture company set up by AMSBIO and the University of Strathclyde exploiting the latest advances in microfluidics and 3D culture to develop a novel microfluidic screening platform. he unique combination of microfluidic lab-on-a-chip technology with physiologically relevant 3D spheroids is designed to make drug discovery more closely relevant with what happens in the body...

 

  3D-iPSC Matrix Enables More Accurate In Vivo Predictions

in vitro 3D human induced pluripotent stem cellAMSBIO announces MyEZGel™ 3D-iPSC Matrix - a powerful new tool for in vitro 3D human induced pluripotent stem cell (hiPSC) culture, enabling more accurate in vivo predictions in life science research and development. MyEZGel™ 3D-iPSC is a synthetic xeno-free hydrogel matrix inspired by muscle and spider silk proteins. Beneficially, MyEZGel™ is proven to overcome basic problems associated with traditional...

 

  Cell Culture Medium for Clinical Research

StemFit® Basic03 clinical grade stem cell cultureAMSBIO announces the launch of StemFit® Basic03 clinical grade stem cell culture for regenerative medicine. Provided as a animal-origin free, ready to use media for cell therapy applications, StemFit® AK03N which is the Japanese version of Basic03 has already been accepted by Pharmaceuticals and Medical Devices Agency, Japan (PMDA) for retinal regenerative medicine clinical trials....

 

  AMSBIO Launch Gene Expression Analysis Service

AMSBIO NanoString serviceAMSBIO, a global provider of gene editing and personalized medicine technologies, has launched a service for high throughput gene expression analysis. Based on the NanoString nCounter platform, the service works with a large array of sample types, including formats such as formalin-fixed paraffin-embedded (FFPE), which have been difficult to analyse by more traditional quantitative PCR...

 

  High Throughput Gene Expression Analysis Service

AMSBIO’s NanoString serviceAMSBIO, a global provider of gene editing and personalized medicine technologies, has launched a service for high throughput gene expression analysis. Based on the NanoString nCounter platform, the service works with a large array of sample types, including formats such as formalin-fixed paraffin-embedded (FFPE), which have been difficult to analyse by more traditional quantitative PCR...

 

  Sustained Gene Expression Technology

Minicircles are circular DNA elementsAMSBIO announces MC-Easy™ minicircle technology for labs looking to produce sustained transgene expression in model animal generation and gene therapy research without the risks of introducing exogenous DNA. Minicircles are circular DNA elements that no longer contain antibiotic resistance markers or the bacterial origin of replication....

 

  Sustained Episomal Gene Expression Free from Foreign DNA

gene strandAMSBIO announces MC-Easy™ minicircle technology for labs looking to produce sustained transgene expression in model animal generation and gene therapy research without the risks of introducing exogenous DNA. Minicircles are circular DNA elements that no longer contain antibiotic resistance markers or the bacterial origin of replication....

 

  AMSBIO Signs Global Agreement for Groundbreaking Myotube Technology

stem cellsAMSBIO has signed an agreement with Genea Biocells (San Diego, USA) to become global distribution partner to the academic community for its groundbreaking skeletal muscle differentiation product range. Genea Biocells developed the world’s first protocol to robustly differentiate human pluripotent stem cells to skeletal muscle cells with high yields and without cell sorting or genetic manipulation (Caron et al. 2016)....

 

  Immunotherapy Used to Treat Aggressive Colon Tumors

cancer cellsAMSBIO reports on ground breaking research by the Institute for Research in Biomedicine (IRB), Barcelona that cites use of its proprietary 3D organoid technology to develop a mouse model that mimics advanced human colon cancer. This model has allowed them to study the immune system response for the first time. In a short space of time, therapies based on...

 

  Novel Microfluidic Platform for Cancer Research

AMSBIO, a transatlantic life sciences company, and the University of Strathclyde (Glasgow, UK) have pioneered a multidisciplinary approach combining expertise in microfluidics and 3D culture to develop a novel microfluidic platform for cancer research. The new platform combines microfluidic lab-on-a-chip technology with physiologically relevant 3D spheroids to enable formation and long-term culture of 3D multicellular tumors / organoids for drug screening and...

 

  Isogenic Panels of Neuronal iPSC Derivatives

AMSBIO announces the launch of a new range of induced pluripotent stem cell (iPSC) derived neural stem cells (NSCs) and neural lineage progenitors.For several years, neuroscience research using cell line and animal models of degenerative neurological disorders such as Parkinson’s and Alzheimer’s disease has been challenged to translate results into in vivo conditions, whether for basic understanding of disease pathology or for the screening of targeted drug therapies....

 

  Highest Stability Recombinant Wnt3a for Organoid Culture

StabiliserAMSBIO has introduced recombinant Wnt3a with a new Wnt stabilizer that significantly extends the activity of this protein in serum-free medium from a half-life of just 2 hours to around 30 hours.

Wnt-3a is a protein that is encoded by the Wnt3a gene. The Wnt gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis, adipogenesis and in several other developmental processes...

 

  Highly Efficient Substrate for Culturing Pluripotent Cells

cell culture matrix compatibleAMSBIO announces iMatrix recombinant Laminin-511 E8 fragments, an innovative cell culture matrix compatible with a wide variety of cell types, and exceptionally well suited for pluripotent stem cells.

Laminin-511 is a major component of the basement membrane, which is expressed in early development of the embryo and can be used as a matrix for pluripotent (ES/iPS) stem cells, as it binds to integrin on cell surfaces....

 

  AMSBIO Introduces Highly Efficient Substrate for Culturing ES/iPS Cells

green celliMatrix recombinant Laminin-511 E8 fragments is an innovative cell culture matrix compatible with a wide variety of cell types, and exceptionally well suited for pluripotent stem cells.

Laminin-511 is a major component of the basement membrane, which is expressed in early development of the embryo and can be used as a matrix for pluripotent (ES/iPS) stem cells, as it binds to integrin on cell surfaces....

 

  Cryopreservation of Hematopoietic Stem Cells

optimised GMP grade cryopreservationHSC-BANKER® from AMSBIO is a new optimised GMP grade cryopreservation medium for the banking of hematopoietic stem cells isolated from umbilical cord blood, peripheral blood and bone marrow.    

In a comparative study on the cryopreservation of hematopoietic stem cells, performed by the Cord Blood Bank of the Japanese Red Cross Society, results using HSC-BANKER® were shown to at least equivalent to conventional protocols using DMSO and DEXTRAN. Manufactured to be completely free of serum and animal derived components, HSC-BANKER® contains only European or US Pharmacopoeia graded ingredients making it suitable for storage of...

 

  AMSBIO Introduce Herpes Virus Entry Mediator Product Range

Herpes VirusAMSBIO has introduced a new range of Herpes Virus Entry Mediator (HVEM) products for use in immuno-oncology research. 

These new products will be of great interest to researchers studying TNFR family members such as CD137 (4-1BB), GITR, OX40, CD27, and other co-stimulatory proteins involved in B and T cell development, immune activation, and antitumor immune responses. The AMSBIO range includes a suite of HVEM products....

 

  Highly Efficient Synthetic Custom mRNAs

AMSBIO announces the launch of a new service for synthesis of custom-designed, highly modified mRNAs prepared by an advantageous in vitro transcription methodology.

mRNAsTraditional approaches for engineering changes in cellular expression profiles have employed mostly DNA or RNA based viral and non-viral vectors. Unfortunately, these methods carry high risks, due to genomic integration with permanent genetic alteration of cells....

 

  Cell-line Derived Controls for Diagnostic Assay Development

AMSBIO announce the addition of mutation cell line Formalin-Fixed Paraffin-Embedded (FFPE) samples and isolated genomic DNA (gDNA) controls to its extensive range of cell line reference standards.

Cell_Line_SlidIn both routine clinical use and diagnostic assay development, biologically-relevant positive and negative controls represent an invaluable resource. To ensure accuracy and reproducibility during IVD assay development and established diagnostic tests, reference standards for genomic DNA analysis and Immunohistochemistry....

 

  AMSBIO Launch Mutation Cell-Line Derived Controls

AMSBIO announce the addition of mutation cell line Formalin-Fixed Paraffin-Embedded (FFPE) samples and isolated genomic DNA (gDNA) controls to its extensive range of cell line reference standards.

Cell_Line_SlideIn both routine clinical use and diagnostic assay development, biologically-relevant positive and negative controls represent an invaluable resource. To ensure accuracy and reproducibility during IVD assay development and established diagnostic tests, reference standards for genomic DNA analysis and Immunohistochemistry (IHC) assays are an essential tool....

 

  CD47 Protein Products for Cancer & Cardiovascular Research

AMSBIO has announced a new range of CD47-relevant products suitable for rapid high throughput screening studies.

amsbioCD47, or Integrin associated protein (IAP), is a transmembrane protein that in humans is encoded by the CD47 gene. Studies have established that CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion and migration.....

 

  New Xeno-free Cell Culture Medium for Regenerative Medicine Research

AMSBIO announces the availability of StemFit¬ģ Basic02feeder-free stem cell culture media.

Regenerative Medicine ResearchStem cells and genome editing offer exciting opportunities within regenerative medicine. However, any clinical application of stem cells requires strict regulation to ensure that the cells are not exposed to ¬†animal derived products. StemFit¬ģ Basic02 is a xeno-free, defined medium for human pluripotent stem cell (hiPSC) culture....

 

  Organoid Culture & Genetic Manipulation

AMSBIO announces its sponsorship of the 'Discovering Organoids: Establishment, Culture & Manipulation’ hands-on training course due to be hosted at Homerton College, University of Cambridge, UK, on 11th and 12th September 2017.

Organoid HandbookAttendees to the 2-day intensive course will receive world-class theoretical instruction and hands-on practical training from leaders in the field of Organoid technology. The course will also cover specialist approaches for the application of CRISPR gene editing technology to Organoid cultures....

 

  Leading French Lab Uses Skeletal Muscle Differentiation Kit to Study Duchenne Myopathy

AMSBIO reports on an independent evaluation and use by I-Stem (Corbeil-Essonnes, France) of the Skeletal Muscle Differentiation kit - a cell culture media system to differentiate human stem cells into functional myotubes.

metabolic disorders.I-Stem was formed in 2005 through a collaboration between Inserm, the French National Institute of Health and Medical Research, and AFM-Telethon the French Association against Myopathies. I-Stem is the largest French laboratory for research and development dedicated to human pluripotent stem cells....

 

  ELISA-like Assay for Hyaluronic Acid

AMSBIO announces the launch of a new Hyaluronic Acid Quantification Kit, based on a highly specific and tightly binding protein to detect and measure Hyaluronic Acid, also known as Hyaluronan or HA.

Hyaluronic Acid Binding ProteinThis product is a competitive ELISA-like kit using a recombinant Hyaluronic Acid Binding Protein (rHABP) optimized to quantify HA polymers of average molecular weight greater than 7.4 kDa in samples such as serum, plasma and culture supernatant....

 

  AMSBIO Announce DermaChip

AMSBIO announces the launch of DermaChip¬ģ - a new high throughput assay technology that allows scientists, for the first time, to reliably measure the genotoxic risk of a whole range of environmental agents (including cleaning agents, household products and industrial chemicals as well as cosmetics) to our skin.

amsbioUsing risk assessment data from a micronucleus assay together with the traditional Comet analysis of cells isolated from treated 3D skin culture models has been shown to be a better predictor of skin toxicity compared to the standard battery of in vitro toxicity assays....

 

  New Purified Cancer Exosome Samples

AMSBIO has introduced a range of purified cancer exosome samples to help researchers study the role of exosomes in cancer development and metastasis.

purified cancer exosomeBy targeted filtration of patient serum using a specific binding method removes protein contaminant to isolate exosome at 95% high purity. Using this proprietary filtration method, the purified tumor exosome does not contain any polymer or detergent (SDS, NP-40 or Triton). The purified tumor exosome can be used for RNA or protein analysis techniques such as qRT-PCR, microarray and mass spectrometry....

 

  AMSBIO Introduce High Efficiency Laboratory Sterilizer

AMSBIO announces its new generation laboratory benchtop sterilizer - the CoolCLAVE‚ĄĘ Plus.

CoolCLAVEThe CoolCLAVE‚ĄĘ Plus provides 20-25x more sterilization power than its popular predecessor (CoolCLAVE‚ĄĘ) by using the power of combined UV and ozone cycles plus a new heating function. The CoolCLAVE‚ĄĘ Plus is highly effective in keeping sterile, or sterilizing contaminated pipettes, pipette tips, gloves, plates, small instruments as well as personal items such as keys, glasses and wallets....

 

  IDO Pathway Products for Immunotherapy Drug Research

AMSBIO offer a wide range of products for IDO pathway research, including cell lines, assay kits and active proteins to be used in IDO pathway research (IDO1, IDO2 and TDO genes).

cellsImmune evasion is one of the identifying hallmarks of cancer, and researchers worldwide are trying to identify the complex mechanisms that enable cancer cells to evade the host’s immune system. Cancer cells use the indoleamine 2,3-dioxygenase (IDO) pathway to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells....

 

  Reporter Lentivirus for Signaling Pathway Studies

AMSBIO has introduced a new range of ready-to-use Reporter Lentivirus for assessing cell signaling activities in virtually any mammalian cell type. 

Reporter LentivirusThese pre-made products use a unique combination of transcription factor reporter technology coupled with lentiviral delivery to provide a simple, highly sensitive method capable of operating over a large dynamic range....

 

  Organoid Banking: Cryopreservation & Thawing of Organoids

AMSBIO¬†reports on an¬†independent study that evaluated the use of CELLBANKER¬ģ and STEM CELLBANKER¬ģ reagents for¬†cryopreservation and thawing of organoids.

/Cryopreservation and Thawing of OrganoidsData is presented that clearly shows that liver organoids recovered and grew well in STEM-CELLBANKER¬ģ‚ÄďGMP, CELLBANKER¬ģ 1 and CELLBANKER¬ģ 2 freezing media after being thawed out after 2 days and 4-days cryopreservation....

 

  High Throughput Myelination Assay Shows Promise in MS Research

AMSBIO reports how, using its Mimetix¬ģ aligned 3D cell culture scaffold, researchers at the MRC Centre for Regenerative Medicine, University of Edinburgh (UK) have created a high throughput myelination assay that shows great promise as a model for research into Multiple Sclerosis.

Marie Bechler, a senior researcherMultiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. MS is a debilitating neurological condition that affects 2.5 million patients worldwide, 100,000 in the UK with 200 new cases diagnosed each week in the US....

 

  Purification Kit for Capture of Circulating Free DNA and Liquid Biospy

AMSBIO has announced the launch of its new cfPure‚ĄĘ Cell Free DNA Purification Kit for scalable and automation-friendly isolation of circulating cell-free DNA (cfDNA) from patient serum or plasma samples.

new cfPure Cell Free DNA Purification KitCirculating cfDNA is normally comprised of DNA fragments from healthy cells.  However, apoptotic cells, necrotic cells, cancer cells, and intact cells all release cfDNA into the bloodstream. In addition, fetal cfDNA can be isolated from peripheral maternal blood. The utility and value of using cfDNA from serum and plasma for non-invasive molecular diagnostics.....

 

  Automation-Friendly Kit for Capture of Circulating Free DNA and Liquid Biospy

AMSBIO has announced the launch of its new cfPure‚ĄĘ Cell Free DNA Purification Kit for scalable and automation-friendly isolation of circulating cell-free DNA (cfDNA) from patient serum or plasma samples.

cfPure Cell Free DNA Purification KitCirculating cfDNA is normally comprised of DNA fragments from healthy cells.  However, apoptotic cells, necrotic cells, cancer cells, and intact cells all release cfDNA into the bloodstream. In addition, fetal cfDNA can be isolated from peripheral maternal blood. The utility and value of using cfDNA from serum and plasma for non-invasive molecular diagnostics...

 

  Proteoglycan and Glycosaminoglycan Research Reagents

AMSBIO has published a new 36-page catalogue that details its comprehensive range of high purity reagents for proteoglycan and glycosaminoglycan research. 

Proteoglycan and Glycosaminoglycan Proteoglycans are glycosylated proteins which contain covalently attached highly anionic glycosaminoglycans (GAGs). Proteoglycans are present in different forms within different types of extracellular matrices and connective tissues. Heparan sulfate proteoglycans (HSPGs) are known to play important structural and functional roles in linking the component proteins of the basement membrane...

 

  High Purity Reagents for Proteoglycan & Glycosaminoglycan Research

AMSBIO has published a new 36-page catalogue that details its comprehensive range of high purity reagents for proteoglycan and glycosaminoglycan research. 

proteoglycan and glycosaminoglycan researchProteoglycans are glycosylated proteins which contain covalently attached highly anionic glycosaminoglycans (GAGs). Proteoglycans are present in different forms within different types of extracellular matrices and connective tissues. Heparan sulfate proteoglycans (HSPGs) are known to play important structural and functional roles in linking the component proteins of the basement membrane, controlling the permeability properties of the membranes and signal...

 

  Cell Line Models & Media for Difficult to Culture Tumor Types

AMSBIO has introduced a new range of cancer cell line models and culture media for the most difficult to culture tumor types where no models may exist.

Culture Tumor TypesAlex Sim, Managing Director at AMSBIO said, "Our new partnership with Cellaria Biosciences expands our existing portfolio by introducing patient-derived cancer models;¬†allowing customers to conduct research and drug discovery¬†initiatives to advance¬†precision medicine.‚ÄĚ Directly derived from patient tumors without any genetic manipulation, these new products provide the assurance of primary cells....

 

  Tools for Neuroscience Research

AMSBIO has published a new 25-page Neuroscience catalogue that details its extensive range of specific tools and reagents to enable researchers stay at the forefront of their field.

amsbio imageCellular models are key tools that open the door to numerous neuroscience applications including neurodegeneration, neurogensis and developmental diseases.  With the discovery that neural stem cells exist in the adult brain many researchers are now seeking to use these cells in in vitro studies....

 

  Ready-to-Use Adeno-Associated Virus Biosensors

AMSBIO announce a new range of ready-to-use adeno-associated virus (AAV) biosensor products.

virusThese viruses encode your chosen biosensor, either calcium or glutamate sensor and are ready for in vivo injection. The new range of Calcium or Glutamate biosensor products comes with a choice of promoter and the ability to include the Cre inducible (FLEx-ON) expression. AMSBIO have packaged these indicators into the most commonly used AAV serotypes (AAV8 and AAV9)...

 

  Research Products for Investigating Cellular Metabolism

AMSBIO offers an extensive range of proteins, antibodies, assays and kits covering every single target of major cellular metabolic pathways including folate metabolism, pyruvate metabolism (with and without oxygen), citrate metabolism, O2 consumption and toxicity, oxidative stress and fatty acid oxygen measurement.

Cellular MetabolismCellular metabolism involves a series of interconnected biochemical reactions catalyzed by enzymes inside a cell, better known as metabolic pathways. These reactions convert a substrate molecule or molecules through a series of metabolic intermediates, eventually yielding a final product....

 

  Fatty Acid Oxidation Kit

AMSBIO has introduced the MitoXpress¬ģ Xtra Fatty Acid Oxidation (FAO) kit to facilitate the convenient measurement of FAO-driven respiration.¬†

MitoXpress¬ģ Xtra Fatty Acid Oxidation (FAO) kit Fatty acid oxidation is the primary metabolic pathway in a variety of tissues, which is particularly important during periods of glucose deprivation. In organs such as liver and skeletal muscle, FAO can provide over 75% of cellular ATP while in cardiac tissue it can be responsible for up to 90% of cellular energy requirements....

 

  AMSBIO 3D Organoid Cultures Used in Groundbreaking Research

AMSBIO reports on the recent publication in Nature Protocols by Dr Meritxell Huch and co-workers which describes development of culture conditions that allow the long-term expansion of adult primary tissues from the liver and pancreas into self-assembling 3D organoid cultures.

3D Organoid CulturesTraditionally adult somatic tissues have proven difficult to expand in vitro, largely because of the complexity of recreating appropriate environmental signals in culture. Huch** and co-workers have overcome this problem and describe recently established protocols for the long-term (> 1 year) expansion and genetic manipulation of adult liver and pancreas cells in 3D organoid culture...

 

  High Quality Proteins for Killer Cell Receptor Research

AMSBIO announces a suite of high quality proteins and biotinylated proteins for research into killer-cell immunoglobulin-like receptors.

Quality Proteins for Killer Cell Receptor ResearchKiller-cell immunoglobulin-like receptors (KIRs), are a family of type I transmembrane glycoproteins expressed on the plasma membrane of Natural Killer (NK) cells and a minority of T cells. They regulate the killing function of these cells by interacting with major histocompatibility (MHC) class I molecules, which are expressed on all nucleated cell types. KIR receptors can distinguish between MHC class I allelic variants, which allows them to detect virally infected cells or...

 

  Human Endothelial Progenitor Cells

AMSBIO has expanded its wide and varied catalogue of primary and progenitor cell types and media with a new range of human endothelial progenitor cells (EPC).

Human Endothelial Progenitor CellsHuman endothelial progenitor cells are a primitive cell type. They are bone marrow derived cells with properties similar to embryonic angioblasts. Progenitor cells migrate into the blood stream and are able to differentiate into a variety of mature vascular endothelial cell types....

 

  New Organoid Culture Handbook

AMSBIO announces an extended and updated edition of its popular Organoid Culture Handbook.

Organoid CultureLaunched at the EMBO Symposium on Organoids: Modelling Organ Development and Disease in 3D Culture, the new 24-page handbook includes valuable information about the latest available products, protocols, example results and research paper citations. Within the protocols section detailed information is provided on a general submerged method for organoid culture, crypt organoid culture techniques...

 

  New products for Wnt Signaling Pathway Research

AMSBIO has launched a comprehensive selection of products for Wnt signaling research including recombinant proteins, stable reporter cell lines, polyclonal antibodies and ELISA assay kits.

 recombinant proteinsWnt proteins are a family of cysteine-rich secreted polypeptides involved in important cell functions including cell to cell communication, cell proliferation, cell migration, cell polarity, survival and self-renewal. In particular Wnt3a signals play an important role in the ability of organoids to expand. Additionally, loss of activation of Wnt expression has been associated with alteration of cell fate, morphogenesis and mitogenesis which has considerable relevance in...

 

  Heparan Sulfate Antibodies Applications Guide

AMSBIO has produced a new 24-page guide that brings together applications, protocols, results and citations to provide an informative resource for researchers using heparan sulfate antibodies.

Immunofluorescence staining on human kidney sections using JM403 Heparan Sulfate antibodyHeparan Sulfate (HS) is synthesized as the glycosaminoglycan (GAG) component of heparan sulfate proteoglycans (HSPGs). It is expressed on the cell surface of virtually all cell types and basement membranes. It displays specific interactions with many biologically active proteins and, thus is involved in many important biological processes....

 

  Efficient DNA Extraction from Plant Tissue

AMSBIO announces MagSi-DNA Vegetal - a powerful kit that enables efficient extraction of genomic DNA from plant tissue.

MagSi-DNA VegetalThe new MagSi-DNA Vegetal kit brings the convenience and cost effectiveness of magnetic bead technology to the world of plant genomics.  Whether you work with DNA extracted from flowers, grain crops, fruits, vegetables, trees, or other plant materials, MagSi-DNA Vegetal is designed to maximize your effectiveness.....

 

  Organoid Progenitor Cells Suitable for Gene Editing

AMSBIO has introduced Cultrex¬ģ Organoid Progenitor Cells that have been derived from normal, healthy mouse small intestine tissue and are continuously cultured using Reduced Growth Factor BME R1 and BME 2.

Cultrex¬ģ Organoid Progenitor CellsThis new introduction extends the range of products offered by AMSBIO to support organoid culture. It will be of particular interest to the large number of leading research groups worldwide using BME 2 organoid matrix that specialise in drug screening applications....

 

  Zika Virus Recombinant Antigens & Antibodies

Anglo-American life science firm AMSBIO announces a new range of recombinant antigens and antibodies for Zika virus, which are suited for the development of rapid assays and to overcome the problem of cross-reactivity with related viruses.

Zika VirusThe Zika virus (ZIKV), which is borne by mosquitos, is causing worldwide concern because of its connection to a neurological birth disorder and its rapid spread across the globe. The imminent 2016 Olympic Games in Brazil, where the epidemic started, is as a consequence suffering withdrawals from a growing number of competitors....

 

  New CRISPR gRNA Lentivector Cloning Kits

AMSBIO has introduced new CRISPR gRNA Lentivector Cloning Kits that provide scientists with a targeted and precise genomic gene editing methodology.

gRNA lentivector cloning kitsTargeted and precise genomic gene editing technologies are today key tools for genomic correction, modification and gene therapy.  The recently discovered CRISPR/Cas gene editing technique offers higher targeting accuracy, much more target sequence selection, much less complexity and less off-target cell toxicity than the previous generation genome editing technologies. To enable CRISPR genomic editing, the AMSBIO kit...

 

  Cell Lines & Controls for Programmed Cell Death Protein Research

AMSBIO has introduced new cell lines and controls for Programmed Cell Death Protein 1 (PD-1) research, and to test inhibitors of the PD-1 / PD-L1 pathway.

 PD-1: PD-Ligands pathwayThe binding of PD-1, a receptor expressed on activated T-cells, to its ligands (PD-L1 and PD-L2) negatively regulates immune responses. PD-1 ligands are highly expressed in many cancers, and their interaction inhibits T-cell activity allowing cancer cells to escape immune surveillance. The PD-1: PD-Ligands pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for...

 

  TIGIT Receptor Products for Immunotherapy Research

AMSBIO has launched a range of new TIGIT receptor products including a Jurkat cell line, Homogeneous assay kits and recombinant proteins for immunotherapy research.

TIGIT receptor productsHuman T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a receptor expressed on the surface of human T cells and NK cells that binds to CD155 and CD112 present on the surface of dendritic cells. The binding of TIGIT with CD155 or CD112 results in inhibition of T cell and NK cell activation....

 

  Cell Lines & Controls for PD-1 Research

AMSBIO has introduced new cell lines and controls for Programmed Cell Death Protein 1 (PD-1) research, and to test inhibitors of the PD-1 / PD-L1 pathway.

PD-1 ResearchThe binding of PD-1, a receptor expressed on activated T-cells, to its ligands (PD-L1 and PD-L2) negatively regulates immune responses. PD-1 ligands are highly expressed in many cancers, and their interaction inhibits T-cell activity allowing cancer cells to escape immune surveillance....

 

  AMSBIO Introduces New Exosome Research Products

AMSBIO has introduced a wide selection of new high quality products for exosome research.

DNA & RNA extraction kitsFormulated to be quick, affordable and easy to use, AMSBIO's new expanded suite of quantification kits, isolation tools, standards, DNA & RNA extraction kits, antibodies and cell culture reagents will facilitate your understanding of exosomes using a wide variety of samples. Exosomes are small endosome derived lipid nanoparticles actively secreted by exocytosis in most living cells. Release of exosomes occurs either constitutively or...

 

  AMSBIO Launch New Immunotherapy Research Products

AMSBIO has launched a range of new TIGIT receptor products including a Jurkat cell line, Homogeneous assay kits and recombinant proteins for immunotherapy research.

new TIGIT receptor productsHuman T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a receptor expressed on the surface of human T cells and NK cells that binds to CD155 and CD112 present on the surface of dendritic cells. The binding of TIGIT with CD155 or CD112 results in inhibition of T cell and NK cell activation. Antibodies and other agents that inhibit this signaling pathway have known to increase the immune response, particularly...

 

  High Quality Products for Exosome Research

AMSBIO has introduced a wide selection of new high quality products for exosome research.

efficient exosome DNA & RNA extraction kitsFormulated to be quick, affordable and easy to use, AMSBIO's new expanded suite of quantification kits, isolation tools, standards, DNA & RNA extraction kits, antibodies and cell culture reagents will facilitate your understanding of exosomes using a wide variety of samples. Exosomes are small endosome derived lipid nanoparticles actively secreted by exocytosis in most living cells. Release of exosomes occurs either constitutively or...

 

  Real-time Intracellular Oxygen Assay

AMSBIO has introduced MitoXpress¬ģ Intra, a novel intracellular oxygen assay based on a 96 or 384-well fluorescence plate reader-based approach that facilitates the real-time assessment of¬†transient changes in cell respiration, oxygen gradients and physiological responses across a range of cell models.¬†

MitoXpress IntraMolecular oxygen is the key substrate of aerobic metabolism. Knowledge of cell oxygenation is therefore central to a detailed understanding of the cellular metabolic response to a particular treatment or manipulation. Traditionally intracellular measurements have proven very difficult, requiring the use of invasive, laborious, low-throughput, technically challenging techniques which in turn have limited the use of...

 

  Novel Reagents for Organoid Growth and Harvesting

AMSBIO has introduced two new products to assist the increasing number of scientists adopting organoid culture as a physiologically relevant model for organ development.

 R-Spondin1 cell lineThese new tools build upon the widespread use of AMSBIO‚Äôs BME2 ‚Äėorganoid matrix‚Äô by leading research groups worldwide. BME 2 is the extracellular matrix of choice for growing and supporting organoid cultures that are increasingly being adopted in drug screening applications. A new R-Spondin1 cell line has been developed that provides a cost-effective solution by which labs can obtain a long-term supply of R-Spondin1...

 

  New Reagents for Organoid Growth and Harvesting

AMSBIO has introduced two new products to assist the increasing number of scientists adopting organoid culture as a physiologically relevant model for organ development.

 Organoid Growth and HarvestingThese new tools build upon the widespread use of AMSBIO‚Äôs BME2 ‚Äėorganoid matrix‚Äô by leading research groups worldwide. BME 2 is the extracellular matrix of choice for growing and supporting organoid cultures that are increasingly being adopted in drug screening applications. A new R-Spondin1 cell line has been developed that provides a cost-effective solution by which labs can obtain a long-term supply of R-Spondin1...

 

  AMSBIO Launch 96-Well CometChip System for DNA Damage Measurement

AMSBIO has launched the 96-Well CometChip¬ģ System - a high-throughput platform developed to simultaneously treat and measure DNA damage induced by different treatments, or among different cell types on a single slide using the Comet assay.

96-Well CometChipDNA damaging agents can promote aging, disease and cancer and are widespread in the environment as well as being produced within human cells as normal cellular metabolites. The ability to quantify DNA damage responses is consequently critical to researchers in public health, pharmaceutical or clinical labs. The CometChip¬ģ is based upon the well-established single cell gel electrophoresis ‚ÄúComet Assay‚ÄĚ, which...

 

  Reducing Non-Specific Binding in Immunoassays

AMSBIO has released a new 16-page practical guide that provides a detailed overview on how blockers can be used to reduce non-specific binding in immunoassays. 

AmsbioImmunoassay Blocking Reagents (Blockers) are typically applied to ELISA and Lateral Flow-based assays, specifically paired monoclonal sandwich assays, competitive assays and antigen capture (IgG/IgM) assays. They work by removing interfering proteins in patient samples that could produce false results and an incorrect diagnosis. Choosing the best assay format depends on the intended application of the...

 

  Practical Guide to Immunoassay Blocking Reagents

AMSBIO has released a new 16-page practical guide that provides a detailed overview on how blockers can be used to reduce non-specific binding in immunoassays.

ELISA and Lateral Flow-based assaysImmunoassay Blocking Reagents (Blockers) are typically applied to ELISA and Lateral Flow-based assays, specifically paired monoclonal sandwich assays, competitive assays and antigen capture (IgG/IgM) assays. They work by removing interfering proteins in patient samples that could produce false results and an incorrect diagnosis. Choosing the best assay format depends on the intended application of the...

 

  AMSBIO Launches Primary Human Cancer Cell Range

AMSBIO announces an extensive range of primary human cancer cells obtained directly from a variety tumor types, including breast, colon and prostate.

human cancer cells Despite significant advances in cancer research and treatments, the eradication of the disease remains elusive. This has led to a more urgent focus on precision medicine and advanced treatments like immunotherapy and the use of oncolytic viruses. Donor derived primary tumor cells offer a more in vivo like model potentially enhancing the development of targeted personalized therapeutics. It is known that using...

 

  Primary Human Cancer Cells

AMSBIO announces an extensive range of primary human cancer cells obtained directly from a variety tumor types, including breast, colon and prostate.

human cancer cellsDespite significant advances in cancer research and treatments, the eradication of the disease remains elusive. This has led to a more urgent focus on precision medicine and advanced treatments like immunotherapy and the use of oncolytic viruses. Donor derived primary tumor cells offer a more in vivo like model potentially enhancing the development of targeted personalized therapeutics. It is known that using immortalized...

 

  AMSBIO Launches New Magnetic Bead Based Products

AMSBIO has announced two new additions to itsMagSi rangemagnetic bead-based products for protein purification, proteomics, and genomics applications.

AMSBIOOffering 100% compatibility with existing protocols, using magnetic bead products from the leading supplier, the clinical grade AMSBIO MagSi kits require little or no re-validation and offer substantial savings in cost. MagSi-NGSPREP Plus offers a simple and quick way to ensure consistent sequencing results. The new kit has been developed to provide an efficient solution for both size selection and clean-up of the successive enzymatic...

 

  New Scalable Protocol to Differentiate Skeletal Muscle Cells from Stem Cells

AMSBIO announces the availability of the world's first kit to differentiate human pluripotent stem cells into functional myotubes.

Scalable Protocol to Differentiate Skeletal Muscle Cells from Stem CellsThe new kit utilizes a highly efficient media based protocol to produce skeletal muscle cells from stem cells in a simple, scalable manner. The potential to differentiate stem cells into specific cell types is revolutionizing life sciences, from new methods of studying developmental biology and novel approaches to producing accurate disease models to techniques to help drug discovery and toxicity testing...

 

  AMSBIO Launch 3D Embedded Invasion Assay

AMSBIO announces the launch of the Oris‚ĄĘ 3D Embedded Invasion Assay ‚Äď a unique product offering quantifiable real-time analysis of cell invasion.

3D Embedded Invasion AssayThis new cell invasion assay is designed to enable cell movement through an extracellular matrix (ECM) in 3-Dimensions, thereby getting you as close as possible to an in vivo experiment using in vitro conditions. The invasion capacity of tumor cells is of particular concern in cancer research, and is a first step to metastasis, the deadliest aspect of the disease. Traditionally, cell invasion assays are performed by seeding cells in...

 

  Fc Receptor Protein Collection

AMSBIO announces an extensive collection of recombinant Fc receptor proteins, including their common variants, to help accelerate the development of therapeutic monoclonal antibodies (mAb).

Recombinant Fc Receptor proteinsTherapeutic antibody efficacy depends not only on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors. As a consequence screening for desired binding affinity to the key Fc receptors is an essential component in the development of a high quality therapeutic mAb. Recombinant Fc Receptor proteins from AMSBIO are uniquely suitable for...

 

  New 3D Cell Invasion Assay

AMSBIO announces the launch of the Oris‚ĄĘ 3D Embedded Invasion Assay ‚Äď a unique product offering quantifiable real-time analysis of cell invasion.

invasion capacity of tumor cellsThis new cell invasion assay is designed to enable cell movement through an extracellular matrix (ECM) in 3-Dimensions, thereby getting you as close as possible to an in vivo experiment using in vitro conditions. The invasion capacity of tumor cells is of particular concern in cancer research, and is a first step to metastasis, the deadliest aspect of the disease. Traditionally, cell invasion assays are performed by seeding cells in a...

 

  Reagents for Autophagy Research

AMSBIO has assembled an extensive collection of autophagy antibodies.

autophagy antibodiesFrom the industry standard autophagy antibody APG8 (MAPLC3) to the newest autophagy antibodies such as LAMP and APG1, AMSBIO is able to provide the most relevant, qualified antibodies for autophagy research. Autophagy is a cellular process not only implicated in the death of a cell, but more widely implicated in the survival of a cell. Autophagy functions as a housekeeping mechanism through disposal of aging and/or dysfunctional proteins and organelles by isolating...

 

  High Efficiency Gene Expression with Pre-packaged Adenovirus

AMSBIO has launched a comprehensive collection of pre-packaged human full-length cDNA ORF and miRNA adenoviruses.

Recombinant adenovirusesFeaturing over 1,240 pre-packaged human miRNA precursor adenoviruses and 30,000 pre-packaged human full-length cDNA ORF adenoviruses the collection will considerably enhance high throughput drug discovery, improve functional genomic studies, and make life science research more cost-effective and efficient. Recombinant adenoviruses are extremely efficient gene delivery systems that are widely used in human gene therapy...

 

  Quick & Easy Selection of shRNA Lentivirus

AMSBIO offers a comprehensive range of more than 54,000 lentivirus for shRNA delivery.

cell lines includes cloning the gene or shRNATo make selection of the optimum lentivirus quick and easy, AMSBIO has developed an online search tool** where you need simply enter your target gene symbol or a key word. Supplied as simple, ready-to-use particles that can be added directly to cells, AMSBIO lentivirus eliminates the need for any transfection reagents. Prepared using proprietary protocols to integrate a real-time fluorescence monitoring tag in the system, each 200ul...

 

  Optimized CRISPR/CAS9 Delivery for Disease Model Generation

AMSBIO has launched DNA-In¬ģ CRISPR ‚Äď an innovative transfection reagent that simplifies and accelerates genome editing using large plasmids and difficult-to-transfect cells for life science researchers generating disease models.

 large plasmidsSince its emergence, CRISPR-Cas9 technology has been rapidly adopted as a mainstream approach for performing genetic manipulation. This powerful tool has transformed the process of generating ‚Äúfootprint-free‚ÄĚ cellular models for studying genetic diseases. Using this approach, researchers can easily generate disease-relevant isogenic models to determine the impact of correcting or introducing disease-relevant mutations on cellular...

 

  Comprehensive Range of Lentivirus for Gene & shRNA Delivery

AMSBIO offers a comprehensive range of more than 54,000 lentivirus for shRNA delivery.

 Range of Lentivirus for Gene & shRNA DeliveryTo make selection of the optimum lentivirus quick and easy, AMSBIO has developed an online search tool where you need simply enter your target gene symbol or a key word. Lentivirus is a subfamily of the retrovirus family. Lentiviruses can deliver significant amounts of genetic information into host cells and integrate it into the cellular genome. Genetically engineered lentiviruses are therefore used as one of the most efficient tools...

 

  Enhanced Glycoselective Bioaffinity Proteins

AMSBIO has announced the introduction of a range of Recombinant Prokaryotic Lectins (RPLs).

Recombinant Prokaryotic LectinsRPLs are enhanced glycoselective bioaffinity proteins that enable efficient detection, analysis and selective isolation of glycosylated biomolecules. RPLs offer many advantages over traditional plant and eukaryotic lectins. They also offer many advantages over current glycoanalytical and chromatographic methodologies that are not glycoselective or require prior release of glycans which results in the sample destruction. Recombinant...

 

  Antibodies Enable Immunoassays to be Used in Methylation Regulation Research

AMSBIO has launched a  unique series of monoclonal and polyclonal antibodies against S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) that allows immunoassays to be used in methylation regulation research. 

MethylationMethylation is involved in nearly every aspect of life. SAM is the sole methyl donor for a variety of methyl-transfer reactions in DNA, RNA, proteins, lipids, phosphilipids, hormones and neurotransmitters. Proper DNA methylation is essential for normal embryonic development. However, when the methyl-transferase gene is homozygously deleted, it is lethal. DNA improperly methylated has been found in many tumors. Alterations in...

 

  PD-1 Inhibitor Screening Assay Kit

AMSBIO has announced a new PD-1 (Programmed Death) inhibitor screening assay kit for cancer research studies.

PD-1 Programmed DeathImmunotherapy for the treatment of cancer is rapidly evolving from therapies that globally and non-specifically simulate the immune system to more targeted activation of individual components of the immune system. The net result of this targeted approach is decreased toxicity and increased efficacy of immunotherapy. The understanding of the checkpoint signalling pathway involving the programmed death 1 (PD-1) receptor and its ligands (PD-L1/2) in...

 

  Easily Automated 3D Cell Culture Growth

AMSBIO¬†has announced the launch of¬†Mimetix¬ģ¬†3D cell culture scaffolds¬†that offer significant advantages for a range of applications including regenerative medicine, oncology research, drug discovery, and as a unique aligned scaffold for neural growth and investigation.

 Mimetix¬ģ 3D cell culture scaffoldsThere is a definite need for more predictive in vitro efficacy assays to reduce both the number of costly drug failures in clinical trials and the number of animals used in pre-clinical testing. Performing certain cell-based assays in 3D has proven to improve their relevance as models; however, when choosing support for the cell culture growth, important factors to consider are: reproducibility of the environment, similarity to the real-life conditions, ease of...

 

  Diverse Pharmacological Modulators for Targets, Pathways and Processes

AMSBIO has announced the launch of PATHM2 small molecules libraries for small scale screening in developmental biology and discovery research.

small moleculePATHM2 libraries are available to identify accessory molecules that improve cell viability, proliferation or yields. All compounds are hand selected to address ‚Äėtraditional‚Äô cascades that play a role in pluripotency maintenance or specific differentiation. Multiple agents are included to interrogate new and emerging networks/targets relevant to stem cell biology.¬†PATHM2 kits are also available to screen your disease model and identify/confirm critical...

 

  Adeno-Associated Virus Services for Gene Delivery

AMSBIO has introduced an expanded range of Adeno-associated virus (AAV) cloning and packaging services.

single-stranded DNA virusesAdeno-associated viruses are single-stranded DNA viruses that can infect a broad range of cell types including dividing and non-dividing cells and are, therefore, widely used vehicles for gene delivery. Clinical trials have not only found AAV to be consistently safe and stable, but their vectors are capable of causing long-term expression in human cells. Therefore, AAV vectors have many advantages that many other vectors do not. To date, recombinant AAV...

 

  AMSBIO Launch Cell Pellet Slides for Immunohistochemistry and in situ Hybridisation

AMSBIO announces the launch of CellMax‚ĄĘ - a new range of high quality, consistent and affordable cell line FFPE slides.

cellmaxMade using a patent-pending process, CellMax‚ĄĘ Cell Pellet Slides have a highly consistent density and homogeneity across the entire cell pellet block that ensures you get accurate results time after time. Cells are harvested by a proprietary trypsin-free method preserving cell surface antigens and inflicting minimal physical damage that could lead to a loss of biomarkers. CellMax‚ĄĘ slides produce accurate and reproducible results for immunohistochemistry...

 

  Ultimate Control for Immunohistochemistry and in situ Hybridisation

AMSBIO announces the launch of CellMax‚ĄĘ - a new range of high quality, consistent and affordable cell line FFPE slides.

CellMax Cell Pellet SlidesMade using a patent-pending process, CellMax‚ĄĘ Cell Pellet Slides have a highly consistent density and homogeneity across the entire cell pellet block that ensures you get accurate results time after time. Cells are harvested by a proprietary trypsin-free method preserving cell surface antigens and inflicting minimal physical damage that could lead to a loss of biomarkers.¬†CellMax‚ĄĘ slides produce accurate and reproducible results...

 

  Protein Delivery Reagent Assists Neurodegeneration Research

AMSBIO announces that Belgian researchers** have cited use of BioPORTER Protein Delivery Reagent to introduce Tau seeds into HEK293 cells.

Neurodegenerative tauopathiesBioPORTER Protein Delivery Reagent is a unique lipid formulation that allows direct translocation of proteins into living cells. Neurodegenerative tauopathies, including Alzheimer disease and frontotemporal dementias, are characterized by neurofibrillary tangles (NFT) composed of intracellular hyperphosphorylated Tau aggregates. Predominantly expressed in neurons, Tau is a microtubule (MT)-binding protein that stabilizes and promotes the assembly...

 

  Neurodegeneration Research Benefits from Protein Delivery Reagent

AMSBIO announces that Belgian researchers have cited use of BioPORTER Protein Delivery Reagent to introduce Tau seeds into HEK293 cells.

Neurodegenerative tauopathiesBioPORTER Protein Delivery Reagent is a unique lipid formulation that allows direct translocation of proteins into living cells. Neurodegenerative tauopathies, including Alzheimer disease and frontotemporal dementias, are characterized by neurofibrillary tangles (NFT) composed of intracellular hyperphosphorylated Tau aggregates. Predominantly expressed in neurons, Tau is a microtubule (MT)-binding protein that stabilizes and promotes the...

 

  Exosomes for Regenerative Medicine Research

AMSBIO has launched a new range of human exosomes to the regenerative medicine tools and technologies market.

ExosomesDerived from placental and adipose derived stem cells, to ensure consistent high quality, these new products are ideally suited for research involving wound healing, stem cell differentiation and tissue regeneration. Exosomes are small vesicles (30‚Äď150 nm) containing sophisticated RNA and protein cargos. They are secreted by all cell types in culture and are found to occur naturally in body fluids, including blood, saliva, urine, CSF, and breast milk. The precise molecular mechanics for...

 

  GMP Grade Cell Cryopreservation Media

AMSBIO has announced the launch of GMP grade STEM-CELLBANKER¬ģ manufactured in strict compliance with Japanese, EU, US, and PICS¬†good manufacturing practice¬†guidelines.

Cell CryopreservationSupplied as a ready-to-use formulation, STEM-CELLBANKER is a chemically defined freezing solution optimised for stem cell and iPS cell storage as well as preservation of other valuable cells. Recent data** supports its unmatched ability for use in cryopreservation of tissues. It is completely free of serum and animal derived component, and contains only US Pharmacopeia, European Pharmacopeia or Japanese Pharmacopeia graded ingredients...

 

  Predicting Response to Cancer Drugs

AMSBIO reports on a study, published in Cell, that demonstrates the power of organoids to capture, in three dimensions, the multiple mutations that occur in tumours.

amsbiopr145-image copyOrganoids, small clusters of cells that accurately mimic the behaviour of human tissue, can be used to test cancer drugs and, eventually, to identify effective personalised treatments for patients. In the described research samples from healthy tissue and cancerous tissue were taken from 20 patients with colorectal carcinoma and used to form the organoids. The organoids were then exposed to a range of colorectal cancer treatments as part of a...

 

  Ready-to-Use Tagged cDNA Clones

Available from AMSBIO TrueORF¬ģ¬†cDNA clones are tagged cDNA clones for protein studies.

amsbioThe TrueORF product line is a new generation of cDNA clone products that enables expression of the encoded transcript as a tagged protein. This facilitates multiple downstream applications that utilize an anti-tag antibody (Myc-DDK or GFP) including protein detection, protein purification, subcellular localization, and others. TrueORFs not only provide an instant solution for tagged protein expression but also offer the flexibility that they...

 

  Organoid Biobank for Predicting Cancer Patient Response to Drugs

AMSBIO reports on a study, published in Cell (1), that demonstrates the power of organoids to capture, in three dimensions, the multiple mutations that occur in tumours.

amsbioOrganoids, small clusters of cells that accurately mimic the behaviour of human tissue, can be used to test cancer drugs and, eventually, to identify effective personalised treatments for patients. In the described research samples from healthy tissue and cancerous tissue were taken from 20 patients with colorectal carcinoma and used to form the organoids. The organoids were then exposed to a range of colorectal cancer treatments as part of a...

 

  Xeno-Free and Endotoxin-Free Human Cytokines

AMSBIO has launched a complete new range of commonly used human cytokines and growth factors.

proteinUnlike most of other commercially available cytokine products, ActiveMax¬ģ cytokines are expressed exclusively in human cells under strict animal-free and xeno-free conditions. Therefore, they are uniquely suitable for human cell culture and assay development. Endotoxin and other non‚Äďhuman components can provoke immune response in human systems. These contaminations are significant complicating factors for human cell culture experiments, in particular...

 

  Exclusive Biotinylated Protein Collection

AMSBIO has launched a new and exclusive biotinylated protein collection specially designed to simplify your research. 

BiotinAttaching biotin to proteins and other macromolecules is an established labelling method which allows specific detection of biotin-tagged molecules via anti-biotin antibody, avidin or streptavidin based reporter systems. Biotinylation reagents are available for targeting specific functional groups or residues, including primary amines, sulfhydryls, carboxyls and carbohydrates. Photoreactive biotin compounds that react nonspecifically...

 

  Biotin Labeled Proteins

AMSBIO has launched a new and exclusive biotinylated protein collection specially designed to simplify your research. 

biotinAttaching biotin to proteins and other macromolecules is an established labelling method which allows specific detection of biotin-tagged molecules via anti-biotin antibody, avidin or streptavidin based reporter systems. Biotinylation reagents are available for targeting specific functional groups or residues, including primary amines, sulfhydryls, carboxyls and carbohydrates. Photoreactive biotin compounds that react...

 

  Guide to Organoid Growth

AMSBIO has launched, at the ‚ÄėFrontiers in Stem Cells & Cancer' EMBL-EMBO Symposium, a guide that illustrates a variety of organoids grown from different tissues by leading international research groups using BME 2 reduced growth factor extracellular matrix that is available from the company.

organoid growthOrganoids are organ-like structures that can be formed by 3D cell culture and differentiation of stem cells or organ progenitors. Organoids are capable of recapitulating aspects of organ function in in vitro. The current research and therapeutic potential of organoids include organogenesis models, drug testing, tumor / disease models, toxicity screening, personalised medicine and regenerative medicine / organ replacement. BME 2 reduced growth...

 

  New Tools and Services for Immunotherapy Discovery

AMSBIO has announced a new range of purified, soluble immunoreceptors involved in key signalling pathways. 

cell cultureTogether with new indoleamine 2,3-dioxygenase (IDO) assay kits  these products that can be used to screen for inhibitors of protein-protein interaction, as well as neutralizing antibodies that serve as positive controls for inhibition. Immune evasion is one of the identifying hallmarks of cancer, and researchers are trying to identify the complex mechanisms that enable cancer cells to evade the host’s immune system.  Cancer cells use the...

 

  Highly Efficient Targeted mRNA Delivery

AMSBIO announces the launch of mRNA-In‚ĄĘ and mRNA-In‚ĄĘ Neuro ‚Äď a new range of high efficiency, targeted transfection reagents.

amsbiopr140Offering high transfection efficiency and expression levels across a broad range of cell types, including stem cells and primary cells, mRNA-In‚ĄĘ is a robust and easy-to-use mRNA delivery solution proven in applications including protein expression and iPSC-reprogramming. ¬†Recognized as among the most difficult cell types to transfect, either freshly isolated or cryopreserved neurons or neural stem cells can be transfected with...

 

  High Efficiency mRNA Delivery

AMSBIO announces the launch of mRNA-In‚ĄĘ and mRNA-In‚ĄĘ Neuro ‚Äď a new range of high efficiency, targeted transfection reagents.

stem cellOffering high transfection efficiency and expression levels across a broad range of cell types, including stem cells and primary cells, mRNA-In‚ĄĘ is a robust and easy-to-use mRNA delivery solution proven in applications including protein expression and iPSC-reprogramming. ¬†Recognized as among the most difficult cell types to transfect, either freshly isolated or cryopreserved neurons or neural stem cells can be transfected with...

 

  New High Throughput PARP in vivo Pharmacodynamic Assay

AMSBIO has introduced a unique High Throughput PARP in vivo Pharmacodynamic Assay that can be used to monitor the efficacy of poly-ADP-ribose polymerase (PARP) inhibitors on PAR formation in vivo; and to measure drug action on PARP in both in vivo and in vitro settings

DNA StrandIn recent news, AstraZeneca reported upon how their ovarian cancer drug Lynparza‚ĄĘ (olaparib) is the first PARP inhibitor to be granted approval by the European Commission and the US Food and Drug Administration (FDA)**. This has led to a surge of interest in this class of drugs, which can exploit tumour DNA repair pathway deficiencies to preferentially kill cancer cells. Dr William Hadlington-Booth of AMSBIO commented "Our High Throughput¬†PARP in vivo...

 

  Novel Organoid Matrix Enables Long-Term Culture of Human Hepatocytes

AMSBIO reports on the recent publication in Cell [1] by Dr Meritxell Huch, Prof Hans Clevers et al. of ground-breaking research using Cultrex BME2 reduced growth factor (organoid growth matrix) to enable long-term (>1 year) culture of genome-stable bipotent stem cells from adult human liver.

amsbiopr138These results open up new experimental avenues towards the use of human liver material expanded in vitro as an alternative cell source for disease modeling, toxicology studies, drug testing, regenerative medicine and gene therapy. Liver diseases (ranging from genetic inherited disorders to viral hepatitis, liver cancer, and obesity-related fatty liver disease) are the twelfth-leading cause of death in the United States. Failure in the management of...

 

  Specificity-Verified Monoclonal Antibodies

AMSBIO has announced the availability of ultraspecific and extensively validated monoclonal antibodies under the UltraMAB‚ĄĘ brand.

amsbiopr137Screening of candidate antibodies against greater than 10,000 human proteins, using a state-of-the-art High Density Protein Microarray Platform, has resulted in the identification of the most specific monoclonal antibodies (UltraMAB antibodies) available for cancer biomarkers and other important diagnostic targets. Performance and specificity are key pre-requisites for antibodies to be used for diagnostic and therapeutic applications. To ensure...

 

  Highly Efficient Neural Transfection Reagent

AMSBIO announces DNA-In‚ĄĘ Neuro¬†- a new generation transfection reagent developed specifically for maximum¬†nucleic acid delivery into neurons, typically achieving a 2-fold or greater improvement in efficiency over¬†currently available competing reagents.

amsbiopr135Neurons are among the most difficult cell types to transfect. DNA-In‚ĄĘ Neuro Transfection Reagent¬†offers researchers a cost effective, robust and easy-to-use DNA delivery solution for transfecting freshly isolated and cryopreserved neurons.¬†DNA-In‚ĄĘ Neuro Transfection Reagent reproducibly¬†transfects neurons and neural stem cells at optimal efficiency with exceptionally¬†low toxicity to support uncompromised post-transfection assays...

 

  Ebola Antigens and Antibodies for ELISA

AMSBIO has announced several products suitable for the development of an ELISA detection assay for the Ebola virus.

amsbiopr136The new products comprise 3 different monoclonal antibodies to the Ebola virus and 2 recombinant proteins (from the Sudan and Zaire strains) suitable for use in producing an optimised ELISA test kit for Ebola. An antigen-capture enzyme-linked immunosorbant assay (ELISA) test for Ebola offers the possibility of diagnosis within the first few days after symptoms begin. Ebola, also known as Ebola hemorrhagic fever, is a disease that typically...

 

  A New Magnetic Technology for Bioseparations and Studies of Biomolecular Interactions

AMSBIO announces MagSi-Direct - a revolutionary technology that brings the power, simplicity, and convenience of magnetic separation to researchers involved in cell biology, protein chemistry, flow cytometry, diagnostics development and many other fields.

amsbiopr125MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads.  It is particularly suited for exploiting interactions between a biomolecule and its binding partners.  With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to which the starting molecule has bound....

 

  3D Triculture Model for Evaluating Breast Cancer Progression

amsbiopr129
A new application note from AMSBIO, previously presented at both the 2014 Beatson International Cancer conference and the ELRIG Drug Discovery 2014 meeting in Manchester UK, introduces a more predictive and realistic model for early stage drug screening of cancer therapeutics.

The report shows that incorporating vascular and stromal cells with breast cancer tumor spheroids allows them to more closely mimic the extracellular environment, cellular architecture and behaviour of actual tumors; this triculture promotes growth, invasion and endothelial recruitment. Current 2D models for evaluating breast cancer progression do not provide a comprehensive, physiological approach to modeling the...

 

  Exquisite ‚ÄėMade-to-Measure‚Äô Phospho-Specific Polyclonal Antibodies

Drawing upon over 20 years’ experience - AMSBIO has developed a custom phospho-specific antibody production service that is both reliable and produces high quality product. 

ams bioThis service includes synthesis of phosphorylated and non-phosphorylated peptides, conjugation to a carrier protein, immunization, serum production and a 2-step affinity purification of the antibodies. To ensure absolute specificity for each phosphorylated amino acid a stringent dot blot testing regime is carried out guaranteeing that for all projects the phospho peptide is preferentially recognized. A complete package of non-phosphorylated and phosphorylated peptides, pre-immune sera and...

 

  Consistent & Efficient Purification of NGS Library Reactions

AMSBIO announces MagSi-NGSPREP- a magnetic bead based tool that offers an efficient solution for DNA clean-up and size selection in Next Generation Sequencing (NGS)applications.

amsbioMagSi-NGSPREP supports all standard DNA clean-up protocols encountered during Next-Gen library preparation, including the classical one-sided and two-sided "solid phase reversible immobilization" (SPRI) size selection protocols. The simple and flexible protocols employed using MagSi-NGSPREP can be adjusted to your specific application and NGS platform. MagSi-NGSPREP can be used manually but is also easy to automate fo...

 

  High Quality In Vitro Cell Models for Cortical Neurophysiology

AMSBIO offers an extensive range of iPSC derived neural cells including normal and Alzheimer's disease neural progenitor cells, and cerebral cortical neurons.

amsbioThese neural cells are derived using integration-free, fully defined neural induction conditions. AMSBIO neural cells are capable of generating a spectrum of cortical neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. Cerebral cortical neurons are implicated in numerous neurological diseases including Alzheimer's disease, autism, epilepsy and stroke. Despite strong interest in these diseases, high quality human in...

 

  Compact Ozone Sterilizer Eliminates Contaminants and Germs

The Ozilla‚ĄĘ from AMSBIO is a new high quality, purpose-built ozone gas generator.¬†

ozillaMeasuring just 13 x 11 x 5 inches (32 x 28 x 13 cm), it will fit in most standard laboratory cell culture incubators, air incubators, cell culture hoods, PCR hoods, or any other environment where a sterile atmosphere is critical. Following simple operational instructions the Ozilla‚ĄĘ is able to completely eliminate airborne as well as surface contaminants and germs including bacteria, phage, and fungus...

 

  Powerful Tool for Genomic Editing

AMSBIO announces the introduction of CRISPR/Cas9 - a full gene editing tool designed to produce a genetically modified cell using any mammalian cell line and targeting any gene.

amsbiopr122CRISPR/Cas9 is revolutionizing the field of genomic editing by providing scientists with a powerful tool able to change any gene, in any cell in a highly targeted manner and without introducing foreign DNA. The benefits of CRISPR/Cas9 over previous forms of gene editing, such as TALENs and zinc finger, are that it is much simpler to implement and has higher efficiency at performing bi-allelic gene modifications...

 

  Efficient Delivery of Proteins into Living Cells

BioPORTER¬ģ Protein Delivery Reagent from AMSBIO is a unique lipid formulation that allows direct translocation of proteins into living cells.

amsbiopr119BioPORTER is the first and only lipid-based protein delivery system that efficiently transports proteins into living cells. Comprising a unique cationic lipid mixture that interacts non-covalently with the protein, BioPORTER creates a protective vehicle for immediate protein delivery. BioPORTER makes studying protein functionality faster and easier than ever before by bypassing the traditional DNA transfection, transcription, and protein translation processes....

 

  AMSBIO Publishes Comprehensive Cell Culture Handbook

Drawing upon a wealth of experience of working with a wide range of 3D cell culture procedures and formats - AMSBIO has produced an extensive 48-page handbook for research scientists looking to culture cells in more physiologically relevant environments.

amsbio cellsOver the past two decades, many researchers have actively sought ways to culture cells in 3D. The conclusion reached by many researchers is that there is no single optimal solution, each cell type needs a different environment and many biological processes may need specific methods to study them. Leading the field in the provision of solutions for 3D Cell Culture, AMSBIO’s scientists have distilled the best technologies into a useful guide....

 

  New Device for Removal of Dying and Dead Cells

AMSBIO announces ClioCell‚ĄĘ an ex-vivo device for removal of dying and dead cells, improving viability and quality of cell populations and their subsequent productivity.

dead cell amsbioThe system comprises super-paramagnetic nanoparticles which have been coupled with proprietary elements that bind to dead and dying cells and cell debris. The resultant product selectively initiates dead-cell removal, emulating dead-cell clearance mechanisms which operate in-vivo to keep tissues functioning optimally. This technology is step-changing, providing new opportunities to optimise cell growth, culture and storage.

 

  Ultra Low Adhesion Delivers Superior 3D Spheroid Cell Culture¬†

AMSBIO Lipidure¬ģ-Coat low adhesion plates and dishes are shown in cited research to be one of the most effective tools for state-of-the-art 3D spheroid cell culture.¬† These new plates and dishes are available in 384-well format optimised for drug screening or other high throughput applications.

amsbiopr116Spheroid cell culture is based on the spontaneous formation of an aggregation of cells in an environment where the interactions between cells are superior to the interactions between cells and substrate. This can be achieved by using low-adhesion cell culture conditions. Lipidure¬ģ-Coat surfaces¬†use¬†MPC (2-methacryloyloxtethyl phosphorylcholine), a biocompatible synthetic polymer with the same structure as the phosphorylcholine polar bases that form cell membranes. As a consequence of the high biocompatibility of this coating, cells will not adhere to the surface of Lipidure¬ģ-Coat plates or dishes...

 

  Animal-Free and Endotoxin-Free Stem Cell Factors

A new range of animal-free and endotoxin-free growth factors and cytokines, tailored to stem cell research, has been launched by AMSBIO ‚Äď a leading supplier of recombinant proteins.

Animal Free and Endotoxin Free Stem Cell Factors

The success of stem cell research depends on the development of optimal cell culture systems. Both expansion and differentiation of stem cells is highly reliant on growth factor and cytokine supplements, with the activity and purity of these recombinants being critical to successful research and clinical applications....

 

  3D Cell-Based Models for Regenerative Medicine & Drug Discovery

Presented by Dr Elad Katz, a senior scientist at AMSBIO, a new on-demand webinar explores the potential of 3D cell-based models for regenerative medicine and drug discovery.

3D Cell Based imaging for Drug Discovery

Two-dimensional (2D) cell cultures have provided a number of breakthroughs for understanding human tissues and diseases, as well as for discovering and testing new drugs. However, 2D cell cultures have limitations, such as limited cell-cell and cell-matrix contacts, flat cellular morphologies and a lack of realistic mass transfer gradients. As a result, technologies that facilitate growing cells in three-dimensional (3D) configurations have been developed to make cellular behaviors in vitro better resemble the body...

 

  Improving Overall Growth & Performance of Primary Neurons

Developed as an alternative to B27¬ģ * - GS21 from AMSBIO is a next generation serum-free neural media supplement, based on the formulation of NS21 Supplement, designed to improve the overall growth and performance of primary neurons.

B27 to GS21 from AMSBIO is a next generation serum free neural media supplement

GS21 has been specifically optimized for the maturation and long-term viability of primary rat and mouse neurons in culture, without the need for co-culture with astrocyte feeder cells. In experimental tests, GS21 has been shown to significantly improve long-term viability of rat and mouse primary neurons in vitro, as well as enhance neurite outgrowth of primary neurons in culture. Beneficially, GS21 also supports growth and maintenance of primary neurons at low or high cell density plating...

 

  Detecting Single and Double Strand DNA Breaks in Individual Cells

AMSBIO has announced a new on-demand webinar entitled 'CometAssay: Detecting single and double strand DNA breaks in individual cells'. 

Comet Assay

Detecting single and double strand DNA breaks in individual cells'. Presented by Dr Sandra Woodgate, a Subject Matter Expert for this technique., this informative webinar explores how the Comet Assay quantitates DNA damage and repair from in vivo and in vitro samples of eukaryotic cells. The comet assay or single cell gel electrophoresis (SCGE) is a technique to easily and rapidly detect and quantitate DNA fragmentation associated with DNA damage caused by apoptosis and cytotoxicity....

 

  Webinar Discusses DNA Damage in Individual Cells

AMSBIO has announced a new on-demand webinar entitled 'CometAssay: Detecting single and double strand DNA breaks in individual cells'.

CometAssay Webinar

Presented by Dr Sandra Woodgate, a Subject Matter Expert for this technique., this informative webinar explores how the Comet Assay quantitates DNA damage and repair from in vivo and in vitro samples of eukaryotic cells. The comet assay or single cell gel electrophoresis (SCGE) is a technique to easily and rapidly detect and quantitate DNA fragmentation associated with DNA damage caused by apoptosis and cytotoxicity. The technique can be particularly useful in the field of genotoxicity testing, human biomonitoring, cellular response to DNA damage, and for screening cancer therapeutics...

 

  New Toolkit for Nucleosome & Histone Research

AMSBIO has announced addition of new biotinylated histones and nucleosomes to its expanding range of recombinant nucleosomes, purified nucleosomes and full length histone proteins.

expanding range of recombinant nucleosomes, purified nucleosomes and full length histone proteins

A nucleosome is the basic unit of DNA packaging. It consists of a segment of DNA wound around a core (‚Äúoctamer‚ÄĚ) of 8 histone proteins (two each of histones H2A, H2B, H3, and H4). The ‚Äútails‚ÄĚ of these histone proteins stick out, where they can be modified by a number of different histone acetyltransferases, methyltransferases, PARPs, and other epigenetic enzymes. Many of these enzymes modify very specific sites e.g. EZH2, specifically tri-methylates the lysine at position 27 in the H3 histone...

 

  AMSBIO & Sanguine Biosciences Announce Distribution Agreement

AMSBIO has announced that it has reached agreement with Sanguine BioSciences, abiotechnology company enabling personalized medicine research, to distribute and support its products and services throughout Europe.

AMSBIO Heart and capillariesCommenting on the new agreement Phillip Pridham-Field of AMSBIO said "Sanguine's approach to biospecimen collection and their high patient retention allow researchers to collect the data they need with better turnaround time and with the potential for longitudinal studies. We believe their extensive biospecimen library will be an excellent addition to our current product offerings for researchers in life sciences...

 

  AMSBIO Sponsor Poster Prize at Cancer Conference

AMSBIO, a provider of cutting-edge life science technologies and services for accelerating discovery in cancer research, has continued its sponsorship of the annual poster prize at the Beatson International Cancer Conference (7th -10th July 2013).

amsbiopr102The two winners¬†of the Poster Prize for the¬†best presented and most interesting posters, were this year named as Dr Thomas R Cox and co-researchers** for their work on¬†‚ÄėDeep proteomic analysis of the hypoxic secretome lysyl oxidase as a critical mediator of metastatic lesion formation in bone‚Äô, and Dr Jean Albrengues & co-researchers*** for their work on¬†‚ÄėProduction of LIF cytokine by cancer cells and fibroblasts contributes to the establishment of a pro-invasive tumour microenvironment‚Äô...

 

  High Throughput 96 & 384 Well DNA Purification

MagSi-DNA cleanFIX from AMSBIO offers a cost effective solution for purifying DNA fragments, removing all unwanted side products and reagents, such as single nucleotides, terminator dyes, primers and primer dimers, enzymes, buffers and salts.

MagSi-DNA cleanFIX

In many genomics applications, purification of DNA fragments is required to prevent downstream interference with analysis methods. Purification of PCR reactions often requires removal of dNTPs, primers, enzymes, salt by-products and various additives. Historically purification protocols have involved different sample types, different volumes and often multiple washing and centrifugation steps. Using such methods the errors incurred during sample preparation have resulted in lost time and significant costs due to re-work and lost reagents...

 

  High Yield RNA Isolation without the Paraffin Removal Step

AMSBIO offers a range of kits and reagents for the extraction (isolation) of high quality RNA from FFPE tissues and LCM samples that can be used not only for PCR but also microarray applications.

High Yield RNA Isolation without the Paraffin Removal StepUsing AMSBIO ExpressArt¬ģ RNA isolation technology it is now possible to achieve high RNA yield and maximum sequence length from FFPE or LCM samples without the paraffin removal step. ExpressArt¬ģ RNA technology overcomes traditional limitations placed on research due to limited sample size, RNA degradation and interference from the crosslinking in FFPE samples. ExpressArt¬ģ FFPE RNA-ready isolation and mRNA amplification technology allows researcher to isolate higher quality and quantities of RNA from samples previously unsuitable for gene expression analysis...

 

  Comprehensive Tissue Biorepository and Collection Services

AMSBIO has announced further expansion of its tissue biorepository and collection services to now include blood products from human donors with auto-immune and neurological conditions.

Comprehensive Tissue Biorepository Collection Services

Whole blood, plasma, serum, PBMCs and cerebrospinal fluid samples are available from a wide variety of donors.  In addition AMSBIO is now able to offer collection services of patient samples that meet the demographic and medical history requirements of specific research studies. Drawing upon over 20 years of serving this market - AMSBIO has established one of the most comprehensive ranges of tissue products to advance personalised medicine by putting these valuable samples in the hands of leading researchers...

 

  Highly Specific Aptamer Protein Precipitation Kits

AMSBIO has announced a new range of Aptamer Protein Precipitation Kits that bind with unmatched high specificity and affinity to target molecules.

Aptamer Protein Precipitation kits

The new AMSBIO Aptoprecipitation (AP) / Co-aptoprecipitation (Co-AP) Kits are aptamer based protein precipitation kits designed to provide easy, quick and consistent protein precipitation. The new kits offer a range of unique characteristics and provide significant advantages over alternative methods. Based upon a proprietary oligonucleotide - Aptamer kits will not contribute to protein/peptide background that can interfere with subsequent mass analysis...

 

  Effective Cryopreservation of iPS Cells

STEM CELLBANKER¬ģ from AMSBIO is a chemically defined freezing medium with optimised formulation for stem cells and iPS cells storage as well as other valuable cells.

Stem Cellbanker

In a recent study to determine the best cryopreservation solution to maintain induced pluripotent stem (iPS) cells, a team of researchers from the Okayama University Graduate School of Medicine (Japan) compared 12 kinds of commercially prepared cryopreservation solutions and found that STEM CELLBANKER** outperformed the other 11 solutions. The researchers concluded that STEM CELLBANKER** showed the highest cell viability and proliferation of all the solutions tested and can be widely used as it does not require any special skills to use...

 

  3D Spheroid Assays for Cancer Drug Screening

AMSBIO has introduced a new range of 96-well format 3D Spheroid Cell Proliferation / Viability Assays, providing a new tool to allow cell-based assays to be carried out in 3D.

3D Spheriod Cell ProliferationThe new AMSBIO 3D Spheroid Proliferation/Viability Assay provides a useful tool for modeling tumor response in vitro. The kit utilises a 3D Culture Qualified 96 Well Spheroid Formation Plate alongside a specialised Spheroid Formation Extracellular Matrix to drive aggregation and/or spheroid formation of cells. Upon completion of spheroid formation, the spheroid may be treated with pharmacological agents to evaluate tumor viability after drug treatment...

 

  Custom designed long and highly modified mRNAs

AMSBIO offers a proven service for synthesis of custom-designed, long mRNA and highly modified mRNAs.

Modified mRNAs as templates for in vitro translation

Working from customer supplied target sequence data - AMSBIO has the experience, expertise and facilities to provide a complete, high quality mRNA custom design service. Synthetic mRNA from AMSBIO is supplied highly purified and ready-to-use. Following chemical synthesis of the synthetic DNA, the dsDNA fragments are cloned in a plasmid, purified and full sequencing documentation produced. PCR amplification of the cloned inserts with the primers is then undertaken, purified using spin columns and the resultant DNA template characterised by capillary electrophoresis...

 

  Short Guide to 3D Cell Culture

A new informative booklet entitled ‚ÄėShort Guide to 3D Cell Culture‚Äô has been produced by AMSBIO

Short Guide to 3D Cell CultureDrawing upon a wealth of experience of working with a wide range of 3D cell culture procedures and formats the guide is aimed at assisting research scientists looking to culture cells in more physiologically relevant environments. Traditional monolayer cell culture on plastic dishes or in flasks, rarely recreates the conditions cells experience in vivo. Over the past 20 years, many researchers have actively sought ways to culture cells in 3D...

 

  New Opportunities in Cancer Research Created By Extracellular Matrix

A new white paper, available from AMSBIO, discusses the latest developments in extracellular matrix (ECM) and the opportunities they offer in cancer research

amsbiopr90

At least 80% of cancers are carcinomas, or tumours of the epithelia. Traditionally, cell transformation to a cancerous stage has been evaluated by anchorage dependent growth. More recently, the role of the extracellular matrix, already established in normal epithelial biology, has come to the fore in the study of carcinomas. The extracellular matrix is largely composed of several protein families, notably laminins, collagens and fibronectin. AMSBIO's new white paper focuses on ECM proteins most relevant to cancer research and their use in the oncology field...

 

  Fast Acting Arthritogenic Monoclonal Antibody Cocktails

AMSBIO has announced a new 5-Clone Collagen Antibody-Induced Arthritis (CIAA) kit for the induction of Collagen-Induced Arthritis (CIA) in various species

Fast Acting Arthritogenic Monoclonal Antibody CocktailsCollagen Antibody-Induced Arthritis (CAIA) has been widely used since 1998 when 4-clone cocktail (Arthrogen-CIA¬ģ arthritogenic monoclonal antibodies) kits first appeared. In order to induce consistent arthritis more effectively in various mouse strains including CAIA low responder C57BL/6 mice, and a variety of unpredictable knockout and transgenic mice with C57BL/6 (H-2b) or 129/Sv (H-2b) backgrounds, a new 5-clone cocktail kits have been developed by adding a new clone to the 4-clone cocktail...

 

  Purified Genomic DNA and cDNA Products Save Research Time

AMSBIO has put together a comprehensive range of genomic DNA and cDNA products derived from various human normal and disease state tissue types. These purified samples save valuable research time allowing the immediate identification of genes of interest without the need to acquire tissues and perform in-house processing

amsbiopr89AMSBIO has added cancer and normal tissue cDNA arrays to its cDNA range which also includes individual PCR-ready first strand samples and panels. The cDNA in each array is synthesized from high quality total RNA from pathologically-verified tissues. Each array is provided with clinical information and QC data that has been both normalized and validated with ß-actin in two sequential qPCR analyses...

 

  Integrating matrix into 3D spheroid culture enables high throughput measurement of cell invasion

AMSBIO has announced the launch of the 3D Culture 96-Well BME Cell Invasion Assay to address the growing need for more complete and physiologically predictive cancer invasion models

3D Culture 96-Well BME Cell Invasion Assay Invasive migration is a fundamental function underlying cellular processes such as angiogenesis, embryonic development, immune response, metastasis, and invasion of cancer cells. AMSBIO's new 3D Culture 96-Well BME Cell Invasion Assay offers a flexible, standardized, high-throughput format for quantitating the degree to which invasive cells in 3D spheroid cultures penetrate a barrier consisting of basement membrane components in response to chemo attractants and/or inhibiting compounds...

 

  Extracellular Matrix Combinatorial Library Launched

AMSBIO is a leading supplier of innovative tools for growing cells in a physiologically relevant manner. A unique Extracellular Matrix (ECM) Mimetic Library for engineering surfaces to direct receptor binding specificity, signalling and growing cells in 3D has been launched

Extracellular Matrix Combinatorial LibraryContaining nearly 300 biomimetics of Fibronectin, Vitronectin, Laminin and Collagen, for coating plates or creating 3D culture scaffolds, AMSBIO's new ECM combinatorial library provides a powerful tool for identifying the cellular adhesion profile of your cell line or tumour against the widest commercially available collection of cell surface receptor binding peptide motifs...

 

  Guaranteed Knockdown for siRNA Gene Silencing

AMSBIO has announced its new Trilencer-27 siRNA kit, that contains Dicer-Substrate duplexes, provides critical improvements over the use of traditional 21mer siRNA designs

amsbio

Gene silencing through the use of RNAi has become a primary tool for characterizing gene involvement in disease states and interactive pathways. Offering genome-wide coverage against human, mouse and rat, the AMSBIO Trilencer-27 siRNA kit takes advantage of the natural processing by Dicer to produce 10-fold higher potency and specificity than shorter 21mer RNAi forms. Beneficially the 27mer dicer-substrate duplexes in the kit also evade the radar of the mammalian interferon response when expressed in mammalian cells and initiate strong and specific gene silencing...

 

  Improved cryopreservation of human hepatocytes A recently published article from researchers at the Karolinska Institute details an improved protocol for cryopreservation of primary human hepatocyte using STEM-CELLBANKER¬ģ cryopreservation solution from AMSBIO.

STEM-CELLBANKERIn the article the authors compare cryopreservation of liver hepatocytes using STEM-CELLBANKER with the frequently used DMSO-University of Wisconsin (DMSO-UW) medium protocol. Both protocols yielded hepatocytes with good P450 function, however, the STEM-CELLBANKER protocol gave a higher viability than the DMSO-UW cryoprotectant. The researchers concluded that STEM-CELLBANKER beneficially is also xeno-free and will be applicable to cryopreservation of clinical-grade primary human hepatocytes...

 

  PMBC's offer high survival and recovery rates AMSBIO has introduced the ImmunoPureTM range of peripheral blood mononuclear cells (PBMCs) supplied in proprietary reagents that ensure high survival and recovery rates.

amsbioImmunoPureTM PBMCs are a variety of immune cells derived from the peripheral blood of normal healthy human adult donors collected at IRB-approved blood banks.  Seven types are currently available and consist of a variety of immune cells derived from the peripheral blood of normal adults, thereby qualifying them for a diverse number of cell-based experiments...

 

  On-demand webinar discusses latest advances in 3D Cell Culture technology AMSBIO, a supplier of advanced 3D tools to the life science community, recently participated in a '3D Cell Culture in Drug Discovery and Disease Modeling' webinar. Due to huge demand, the webinar which aired on 22nd May, has been reproduced in an on-demand version.

3D tools to the life science communityDriven by the limitations of 2D cell cultures - scientists search for alternative solutions that mirror the environment experienced by normal cells in the body and replicate complex tissue structures and in vivo-like morphology. The '3D Cell Culture in Drug Discovery and Disease Modeling' webinar focuses on discussing the latest advances in 3D technology and its contribution to conducting more realistic research...

 

  Stable Cell Line Generation Using Lentivirus AMSBIO has announced a fast service for custom generation of high quality, affordable over-expressing or knockdown stable cell lines.

Stable Cell Line Generation Using LentivirusAMSBIO's custom generation of stable cell lines includes cloning the gene or shRNA of interest into a safe lentiviral vector, generating the lentivirus and transducing into the cell line of your choice. The service allows you to choose a constitutive or inducible promoter, a tag, an antibiotic selection marker and a fluorescent marker. The ease of providing your target templates or choosing one from AMSBIO's cDNA collection ensures rapid turnaround.

 

  Informative Guide to Gene Silencing and Delivery A new guide entitled 'Top Ten Tips for Gene Silencing & Delivery' is available

amsbiopr75Drawing upon extensive experience of gene silencing techniques the new guide is aimed at assisting research scientists using or planning to use gene knockdown as a method of revealing the function of genes in biological processes. The informative guide provides expert hints and tips on topics including: How to determine the RNAi tools best suited to your application ; The importance of performing appropriate positive and negative controls...

 

  Proliferation Assays Ease Downstream Applications of 3D Cell Culture AMSBIO has announced a new range of 3D proliferation assays that make downstream applications of 3D cell culture easier.

3D proliferation assaysThe past few years have seen a boom in the number of papers published covering 3D cell culture, as researchers working in areas from cancer research to stem cells are increasingly seeing the benefits of this technique. AMSBIO supplies the most advanced and extensive range of 3D tools to the life science community...

 

  3D Culture Cell Harvesting Kit AMSBIO Cultrex The AMSBIO Cultrex¬ģ 3D Culture Cell Harvesting Kit is based on a non-enzymatic approach that prevents biochemical degradation during processing and overcomes the problems associated with extracting cells from 3D culture in BME or Laminin I. The quality of the harvested cells is ideal for Western blotting and RNA and DNA analysis. In 3D culture, cells are grown in a microenvironment of specialized proteins that mimics in vivo conditions and allows the cells to organise into complex structures rather than uniform monolayers...

 

  Extensive Range of Bromodomain Protein Domains & Profiling Kits AMS BiotechnologyAMSBIO provides an extensive portfolio of bromodomains and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery. Bromodomains (BRDs) are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine...

 

  Article describes potential of Stem Cells in Neuroscience Research AMS Biotechnology (AMSBIO)AMSBIO has written an informative technical article to enable neuroscience researchers to learn more about a new method to control and direct differentiation of physiologically relevant neural cell types using stem cell qualified reagents. Stem cells have revolutionized our approaches to and understanding of neuroscience. The key to research success is the ability to control and direct differentiation into physiologically relevant neural cell types...

 

  ELISA kits enable precise analysis of key neurodegenerative-related biomarkers Neuroscience catalogueAMSBIO has expanded its range of rat specific ELISA kits that enable precise analysis of key neurodegenerative-related biomarkers while minimizing the use of precious samples. Visitors to the recent Neuroscience 2011 meeting in Washington DC responded enthusiastically to AMSBIO's range of over 2300 rat specific ELISA kits tailored for the sensitive and specific quantification of your cytokine, growth factor, or chemokine of interest. Particular interest was shown in new rat specific analyte ELISA kits for various Neurotrophins, TGFb1 and rat leptin as well as a series of ganglioside ELISAs...

 

  Unlocking the potential of Stem Cells in Neuroscience Research Stem Cells in Neuroscience ResearchAMSBIO has written an informative technical article to enable neuroscience researchers to learn more about a new method to control and direct differentiation of physiologically relevant neural cell types using stem cell qualified reagents. Stem cells have revolutionized our approaches to and understanding of neuroscience. The key to research success is the ability to control and direct differentiation into physiologically relevant neural cell types...

 

  Stem cell qualified mouse Leukemia Inhibitory Factor (mLIF) amsbiopr61AMSBIO has added mouse Leukemia Inhibitory Factor (mLIF) to its extensive range of stem cell research products. Functionally tested with mouse ES cells, the affordably-priced AMSBIO recombinant mLIF combines both high quality and high activity. Mouse Leukemia Inhibitory Factor is a lymphoid factor involved in a number of biological processes including neural and hematopoietic cell differentiation, bone and fat metabolism, and mitogenesis of certain factor dependent cell lines...

 

  Videos Demonstrate Utility of Unique 3D Cell Culture Technology AMSBIO 3D cell cultureAMSBIO have added a major new suite of video presentations and a bibliography of downloadable technical papers that demonstrate the utility of alvetex¬ģ - a unique synthetic scaffold that enables routine 3D cell culture. alvetex¬ģ is a highly porous polystyrene scaffold engineered into a 200¬Ķm thick membrane which provides a 3D space into which cells can invade, proliferate and grow. The vertical axis of the third dimension enables additional layers of cells to form complex 3D interactions...

 

  Optimised Gene Delivery Solution for Hard-to-Transfect Cells AMSBIO GeneInAMSBIO has introduced GeneInTM - a new transfection reagent specifically designed to transfect stem cells and primary cells. Comparative studies against other commercially available reagents show GeneInTM to be superior in transfection efficiency with minimum cytotoxicity...

 

  Chemically Defined Stem Cell Cryopreservation Solution STEM-CELLBANKER¬ģ from AMSBIO STEM-CELLBANKER¬ģ from AMSBIO is a chemically defined freezing medium with optimized formulation for stem cells and iPS cells storage as well as other valuable cells. Supplied ready-to-use with a simple usage protocol, STEM-CELLBANKER¬ģ is completely free of serum and animal derived components, and contains only European or US Pharmacopoeia graded ingredients...

 

  AMSBIO and Chondrex Cooperate On Arthritis & Inflammation Research amsbioAMSBIO has announced a pan European partnership with Chondrex Inc. to market their high quality arthritis and inflammation reagents to academics and pharmaceutical companies that do research in these fields. The range includes a suite of high quality reagents such as highly purified cartilage collagen and collagen monoclonal antibodies to provide scientists with the necessary tools to study the pathogenesis as well as to develop and screen potential therapeutics for Rheumatoid Arthritis (RA)...

 

  Investigating protein-binding properties of Heparin, Heparan Sulfate and other glycosaminoglycans (GAGS) amsbioAMSBIO has announced a suite of exciting new products for investigating the protein-binding properties of Heparin, Heparan Sulfate (HS) and other glycosaminoglycans (GAGS). Such investigations have traditionally been constrained by the need for chemical modification prior to attachment to inert or derivatized surfaces. The AMSBIO Heparin/GAG Binding Plate offers a simple solution to this problem - the specially-prepared plate surface adsorbs GAGS without modification whilst maintaining their protein-binding characteristics...

 

  AMSBIO moves to support the Glycobiology research community AMSBIO moves to support the Glycobiology research communityAMSBIO has announced a package of initiatives to support the Glycobiology research community following the recent announcement by Seikagaku Corporation that they plan to discontinue their research reagents and glycobiology biochemicals business as of September 30th 2011...

 

  Potent Reagent for Reliable Stem Cell Differentiation Potent Reagent for Reliable Stem Cell DifferentiationAMSBIO announces ec23¬ģ* - a stable synthetic retinoid that has been proven in independent testing** to potently induce and reliably control stem cell differentiation. Stem cells self renew and have the ability to differentiate into a variety of cell types. They represent a valuable renewable resource from which functional tissues can be derived. Such materials can subsequently be used for research, disease modeling, drug testing and ultimately therapeutic applications...

 

  Reproducible and Quantifiable Directed In Vivo Angiogenesis Assessment Assays Directed In Vivo Angiogenesis Assessment AssaysAMSBIO has announced a new range of Directed in vivo Angiogenesis Assay (DIVAATM) kits that address the short-comings of the traditional plug assay by controlling the site for angiogenesis, increasing reproducibility, conserving test compounds, and supplying more statistical data for quantitative analysis. This range of kits is designed to test for activation, inhibition and tube formation...

 

  Pluripotent Stem Cell Line Assessment qPCR Kit PluriPCR‚ĄĘ KitAMSBIO has announced the launch of the PluriPCRTM Kit, a new benchmark to revolutionize the definition of stem cell pluripotency. The PluriPCR kit has been designed as a quantitative, easy to use, and reliable assay of five genes strongly specific to pluripotency. These genes: Oct-3/4, Nanog, DNMT3b, Dppa4, and Rex1 are expressed by human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC); all are sharply down-regulated during differentiation.

 

  Reproducible undifferentiated growth of pluripotent stem cells AMSBIO AMSBIO is a leading supplier of Mouse Embryonic Fibroblasts (MEFs) and Newborn Human Foreskin Fibroblasts (NuFFs) for mouse and human pluripotent stem cell culture (ES and iPS cells). All AMSBIO feeder cell products are meticulously derived and comprehensively tested on mouse and human ES stem cells to ensure robust and consistent performance with every lot...

 

  Genuine 3D Cell Culture Technology AMSBIO has announced the launch of Alvetex¬ģ - a unique cell culture scaffold AMSBIO has announced the launch of Alvetex¬ģ - a unique cell culture scaffold that, for the first time, enables genuine 3D cell culture to be grown routinely and cost-effectively. Already successfully applied to numerous applications including drug toxicity models with liver cells, skin raft assays and bone remodeling studies - Alvetex¬ģ provides a stable and inert scaffold for cells to grow, mimicking in vivo growth and formation of tissues in the body...

 

  AMSBIO Announces US Office amsbioAMSBIO has announced, as of 31st March 2011, the opening of a new North American subsidiary company - AMSBIO LLC. After successfully selling innovative life science technologies, biotools and services directly to North American researchers, the new office will be a fully integrated entity supporting the AMSBIO product line with a dedicated sales and service facility in Orange County, California...

 

  A Robust, Quantitative Alternative to the Scratch Assay Oris‚ĄĘ Cell Migration Assay New independent research demonstrates that the OrisTM Cell Migration Assay presents a superior quantitative, high throughput alternative to the scratch assay. Cell migration is integral to many physiological processes, including embryonic development, tissue regeneration, and wound healing. One assay commonly used to study cell migration is the scratch assay creating a cell-free gap, or "scratch", on a confluent cell monolayer...

 

  Knockdown Cell Lines for DNA Repair Studies Knockdown Cell Lines for DNA Repair StudiesAMSBIO has announced a new range of highly efficient knockdown cell lines covering the Base Excision DNA Repair pathway. The new range of 20 DNA Repair Knockdown cell lines was developed to enable scientists to study the molecular etiology of tumour genomic instability and to exploit it in oncology research. The AMSBIO DNA Repair Knockdown cell lines are based upon target-specific LN428 glioblastoma shRNA lentivirus transduced cells that are rigorously qualified and mycoplasma free.

 

  Animal-free Preparation of Human Serum Albumin ecoHSA‚ĄĘAMSBIO has announced the launch of ecoHSA - an animal-free preparation of the human albumin gene produced in the seeds of Asian Rice (Oryza sativa). Commercial human albumin proteins extracted from plasma have multiple and invaluable uses in cell culture work.

 

  Highly Efficient, Reproducible Non-Cytotoxic Transfection Reagent GenePORTER Gold from AMSBIO GenePORTER¬ģ Gold from AMSBIO is a new highly efficient and reproducible lipid-based reagent for effective transfection of a wide variety of cell lines. Molecular target delivery faces many barriers, from crossing the cell type-specific extracellular membrane, to cytoplasmic degradation and translocation across the nuclear membrane. To be effective, the transfection reagent/DNA complexes must overcome all of these challenges whilst minimizing cytotoxicity

 

  Extensive Range of Purified Full Length Human Proteins Extensive Range of Purified Full Length Human ProteinsAMSBIO is now able to offer a range of over 4,000 full length affinity purified human proteins expressed in HEK293 cells and derived using an extensive collection of human cDNA clones. The new range is currently the broadest offering of human proteins produced in human cells. It has been prepared to ensure optimal preservation of protein structure, post-translational modifications and functions.

 

  Ideal controls for PCR, RNA microarray & antibody array studies Ideal controls for PCR, RNA microarray & antibody array studiesThe AMSBIO range of Universal Reference Products (RNA, cDNA and Protein Lysate) has been expanded to include standards for studies involving humans as well as for animal species including Monkey, Dog, Mouse, Rat, and Chicken. These products provide ideal controls for high throughput PCR, RNA microarray and antibody array studies

 

  Kits for Accurate and Reproducible mRNA Amplification ExpressArt¬ģ mRNA Amplification Kits from AMSBIO ExpressArt¬ģ mRNA Amplification Kits from AMSBIO offer an elegant technological solution for qRT-PCR and gene expression array studies that overcomes the limitations of sample quality and quantity. ExpressArt¬ģ technology allows reproducible and precise analysis of challenging samples including Formalin-Fixed Paraffin-Embedded (FFPE), laser captured micro-dissections, needle biopsies, and circulating tumor cells.

 

  Kits for improved nucleic acid recovery from FFPE samples Kits for improved nucleic acid recovery from FFPE samplesAMSBIO has announced new kits for the isolation of high quality RNA from Formalin-Fixed Paraffin-Embedded (FFPE) tissues and LCM samples that can be applied both to qRT-PCR and a variety of microarray platforms.

 

  Selection Guide for Apoptosis Assay Kits & Reagents AMSBIO has AMSBIO has announced an expanded range of assay kits and reagents for the detection and analysis of apoptosisAMSBIO has announced an expanded range of assay kits and reagents for the detection and analysis of apoptosis. A new selection guide has been created by AMSBIO to provide researchers with a quick and easy way to identify and select the best tools to measure apoptosis.

 

  New Cell Migration Assay Dramatically Reduces Cost Of High Content Screening New Cell Migration Assay Dramatically Reduces Cost Of High Content ScreeningAMSBIO has announced the launch of the first of a new generation of cell migration assays designed specifically for fully automated high throughput screening (HTS) utilizing high content screening (HCS) and high content imaging (HCI) systems.

 

  High purity reagents for glycobiology and glycoanalysis

High purity reagents for glycobiology and glycoanalysis

Specialist in high purity reagents for glycobiology and glycoanalysis - AMSBIO - has announced a number of new and unique kits for proteoglycan research.

 

  Optimised E.coli Strain Expresses Insoluble Proteins In Soluble Form Optimised E.coli Strain Expresses Insoluble Proteins In Soluble FormAMSBIO has announced Solu BL21TM Competent E. coli, a significantly improved BL21 host strain for soluble mammalian protein expression. Using a directed evolution approach, a mutant strain of BL21(DE3) E. coli has been developed that can produce soluble protein in the majority of cases where expression in the parent BL21(DE3) yielded no detectable soluble product.

 

  Standardized Comet Assay System Ensures Reproducible Results The CometAssay¬ģ Electrophoresis System and new CometAssay¬ģ Neutral Control cells from AMSBIO enable investigators to consistently optimize neutral Comet assays for highly reproducible results, and to standardize neutral electrophoresis methods between individual users and laboratories.

 

  Ready-to-Use Gene Delivery Tools AMSBIO has announced a new range of expression ready lentiviral particles that allow easy gene delivery into hard to transfect cells including primary cells, non-dividing cells and cells in suspension.

 

  AMSBIO-New Magnetic Beads Enable Faster Protocols AMSBIO has announced a new range of MagSi magnetic beads that incorporate a novel ferro fluid to combine the advantages of small beads and large surface with the magnetic performance and strength of larger beads.

 

  New Magnetic Beads Enable Faster Protocols AMSBIO has announced a new range of MagSi magnetic beads that incorporate a novel ferro fluid to combine the advantages of small beads and large surface with the magnetic performance and strength of larger beads.

 

  Protein Standards for Mass Spectrometry Analysis AMSBIO has announced a new service whereby it can generate high quality Mass Spectrometry (MS) standards for over 5,000 human proteins. Produced in human HEK293T cells and labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, the full length proteins with appropriate post-translational modifications are the best choice for accurate identification and quantification of protein biomarkers

 

  Homogeneous Assay Kits Minimize Assay Complexity AMSBIO has released 4 new homogeneous 384-well format AlphaScreen assay kits - JMJD2A, JMJD2B, JMJD2C, PRMT5 and G9a (a histone methyltransferase).

 

  New Kits for Assessing Oxidative Stress AMSBIO has announced an expanded range of assay kits for the detection and quantification of oxidative stress biomarkers and antioxidants.

 

  Tools to Study Genomic Instability AMSBIO has announced a new second generation PARP in vivo Pharmacodynamic Assay that accurately measures net poly (ADP-ribose) (PAR) levels in cellular extracts and has been used to document differences in PAR levels in human tumour lysates from a variety of tissues, organs and xenografts.

 

  Comprehensive Biorepository of Genomic & Proteomic Tissue Products AMSBIO offers a comprehensive range of certified tissue products for genomic and proteomic research including genomic DNA, cDNA, RNA and protein.

 

  Highly Reproducible Gene Delivery for Stem Cell Research AMSBIO have announced a range of ready-to-use lentivirus supernatant products suitable for many kinds of gene delivery applications including stem cell research.

 

  Non-Animal Recombinant Proteins for Cell Culture & Tissue Engineering Applications AMSBIO has announced a new range of recombinant proteins that can substitute extracellular matrix proteins that are currently extracted from mouse sarcoma.

 

  Easy and Economic Generation of Functional siRNAs The Turbo Dicer siRNA Generation Kit from AMSBIO enables easy and cost-effective generation of a large number of small interfering RNAs (siRNAs) from full-length target genes.

 

  Highly Reproducible Gene Delivery AMSBIO have announced a range of ready-to-use lentivirus supernatant products suitable for many kinds of gene delivery applications including mammalian protein expression, stable cell line construction, cell signal pathway localization and stem cell research.

 

  Sensitive & Specific anti-DDK Antibody for FLAG Epitope Tagging AMSBIO has announced 4C5 - an anti-DDK monoclonal antibody for the detection of DYKDDDDK epitope - the same protein sequence as FLAG-tag*.

 

  Assay Kits for Measuring the Complete Range of HDAC Enzymes AMSBIO has announced 2 new histone deacetylase (HDAC) cell-based assay kits that provide an easy tool for studying the activity and inhibition of the full range of HDAC enzymes (1-11).

 

  Rabbit Monoclonal Antibodies for Immunohistochemistry AMSBIO has announced a new portfolio of rabbit monoclonal and polyclonal antibodies for Immunohistochemistry (IHC) applications. A rabbit custom antibody service is also available.

 

  Accelerate Your Cell Migration Research AMSBIO has announced the addition of the OrisTM Pro Cell Migration Assay to its range of 96-well cell exclusion zone assays for performing cell migration and cell invasion experiments.

 

  A Novel HAMA Blocker for Reduction of Immunoassay Interference amsbio has introduced TRU Block, a highly potent reagent that actively blocks the heterophilic antibody (HA) interference in immunoassays including but not limited to Human Anti-Mouse Antibody (HAMA) interference.

 

  Homogeneous Fluorescence-based Assay for Detecting Intracellular Calcium Mobilisation Amsbio's Screen Quest‚ĄĘ Calcium Assay kit provides a homogeneous fluorescence-based assay for detecting intracellular calcium mobilisation across a broad spectrum of biological targets

 

  Custom Tissue Sections & Microarrays amsbio offers services for custom acquisition, procurement and preparation of tissue sections and tissue microarrays from a wide range of animal and plant species according to client specification.

Drawing upon many years of experience amsbio is able to provide expert consultancy on the design and development of custom tissue sections and tissue microarrays

 

  Standardisation of Direct Detection of DNA Damage In Cells. Amsbio has announced a novel complete assay system for direct detection of DNA damage in cells which includes CometSlides‚ĄĘ, reagents, control cells and an electrophoresis unit.